DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG2990 and HELZ

DIOPT Version :9

Sequence 1:NP_727386.1 Gene:CG2990 / 31934 FlyBaseID:FBgn0030170 Length:1100 Species:Drosophila melanogaster
Sequence 2:XP_006722277.1 Gene:HELZ / 9931 HGNCID:16878 Length:1970 Species:Homo sapiens


Alignment Length:1247 Identity:254/1247 - (20%)
Similarity:397/1247 - (31%) Gaps:447/1247 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MATKRVLTPNILENDNTDVTSSNPQKKFKEQLDFSSDEVENIDWG---------------DNDDF 50
            |.||.:.....|.:: |:..:||.         .|...||::|.|               .::::
Human   127 MVTKDLTRLKTLLSE-TETATSNA---------LSGYHVEDLDEGSCNGWHFRPPPRGITSSEEY 181

  Fly    51 DL---------ALIAAMDSISNHRLELTKWQRCEVVRLEQLPNRKGLKVHVKRISGGDPETADCQ 106
            .|         ....|..:.::.:.||.:||:....||.:|..:.    ..|::||...||    
Human   182 TLCKRFLEQGICRYGAQCTSAHSQEELAEWQKRYASRLIKLKQQN----ENKQLSGSYMET---- 238

  Fly   107 LLPPWNCMPMQVGDTVSLLGKWDPSAGCYVVDKE--QGYCVSH-PDFLI------SGTTVTGSLF 162
                             |:.||..|.....|..|  :|..|.| ||..:      |..|.|.:|.
Human   239 -----------------LIEKWMNSLSPEKVLSECIEGVKVEHNPDLSVTVSTKKSHQTWTFALT 286

  Fly   163 CK------RKSVLQERFR------GLDSGNSVMVIGTLVHELLQKVLRQKLFDKKHIQSALQEML 215
            ||      |.::|.:..|      .:.:|:|...:...|.|..|:.:..|              :
Human   287 CKPARMLYRVALLYDAHRPHFSIIAISAGDSTTQVSQEVPENCQEWIGGK--------------M 337

  Fly   216 ASSSLAHLLY----ASN-----------LIQVEMEDHLMK--FIDPIVSFVAQY-VKGEPPSVLL 262
            |.:.|.|.:|    |.|           :....:|..||:  .||...:...:| :..:...|..
Human   338 AQNGLDHYVYKVGIAFNTEIFGTFRQTIVFDFGLEPVLMQRVMIDAASTEDLEYLMHAKQQLVTT 402

  Fly   263 PEVYRGQIHEICDIEENLWVPQLGLKGKVDVSVKVKNQRQREEIIPLELKTGRASFSMEHKGQLL 327
            .:.:......|.|.|.|                         |...||            |..|:
Human   403 AKRWDSSSKTIIDFEPN-------------------------ETTDLE------------KSLLI 430

  Fly   328 LYQLMHSAQGRDTQSGL---------------LLYLKE-GLLREVA--SGRNEQRDLLMLRNDLA 374
            .||:..||....|||.|               |||::| ...:|::  ||.:..|.||....:  
Human   431 RYQIPLSADQLFTQSVLDKSLTKSNYQSRLHDLLYIEEIAQYKEISNTSGASTSRILLQDTTN-- 493

  Fly   375 YWLTREVAIPASKEDPLEQLPLPEPVYHHSACGNCAYNTICSSFAQKDSSLQLSDSHPLKKLMPQ 439
              :||..                          :|     ||........||:..|..|..:.  
Human   494 --VTRGF--------------------------SC-----CSKLFNLKVQLQILASFMLTGVS-- 523

  Fly   440 LLEHLSEADHAYVQHWCGLLALEEQHNRQSSHVRSFWTKDPAEREKEGIAIRHLKLVKGQEVILE 504
                 ..|.:|......|...|.|..:..:...|...||         :...:|..|..|:::..
Human   524 -----GGAKYAQNGQLFGRFKLTETLSEDTLAGRLVMTK---------VNAVYLLPVPKQKLVQT 574

  Fly   505 EGR----YRQTLELGEEADPSRDLSLSGFDLGEYVVISSTSRLAVAAGFIVSIEARRLDLRLERD 565
            :|.    |..|:|  |:..             ||:.                       |||.|:
Human   575 QGTKEKVYEATIE--EKTK-------------EYIF-----------------------LRLSRE 601

  Fly   566 LSQRYSEETFIIDKHDSQSFATFNFTNLGMLLSEGERFQELRDIIVAKKPPEQHKVL-------- 622
            .    .||..:....|:|....|....|.:.                    |.|..|        
Human   602 C----CEELNLRPDCDTQVELQFQLNRLPLC--------------------EMHYALDRIKDNGV 642

  Fly   623 --PKIILTKGAPILLN----------LNKVQQNAALRALTTS-----SHLLIKGLPGTGKTQTLV 670
              |.|.:|...|...|          ||..|:.|.| |:||.     ..:||.|..|||||.||.
Human   643 LFPDISMTPTIPWSPNRQWDEQLDPRLNAKQKEAVL-AITTPLAIQLPPVLIIGPYGTGKTFTLA 706

  Fly   671 ALVRLLHLLGKS----VLITAQTHSAVDNLIMRLL-PFGLPMMRLGSGSRIHKQLEEISEERLTK 730
            ..|:  |:|.:.    :||...::||.|..|...| |:      :.:|:...:.|......|.. 
Human   707 QAVK--HILQQQETSRILICTHSNSAADLYIKDYLHPY------VEAGNPQARPLRVYFRNRWV- 762

  Fly   731 DCKTVEELEKALGQPSIVGVTCL-GCGHPLFQRRQ-----------------------------F 765
              |||.         .:|...|| ...|..||..|                             |
Human   763 --KTVH---------PVVHQYCLISSAHSTFQMPQKEDILKHRVVVVTLNTSQYLCQLDLEPGFF 816

  Fly   766 DYCIVDEATQVLQPTVLRPL---IHCSKFVLVGDPEQLPPIVRSKEARQRGADETLFQRL----D 823
            .:.::|||.|.::...:.||   ...::.||.||..||.|.|.|:.||:|....:|..||    .
Human   817 THILLDEAAQAMECETIMPLALATQNTRIVLAGDHMQLSPFVYSEFARERNLHVSLLDRLYEHYP 881

  Fly   824 SEKATAVLSLQ-YRMNKTITRLANELTYGGDLKCASDEVSGARFEVELLNEAPRWVQRALTTHLE 887
            :|....:|..: ||.::.|....:||.|.|.|..:..:.:...|          :.....|...|
Human   882 AEFPCRILLCENYRSHEAIINYTSELFYEGKLMASGKQPAHKDF----------YPLTFFTARGE 936

  Fly   888 QAVTLINTGDCLERCQEFVYASQRLVDTCSSIEQSFSEDKDEIRKLTSKKRVSKYTNYCEAGIVM 952
                     |..|:.....|.:..:.:....:|        |:|:                    
Human   937 ---------DVQEKNSTAFYNNAEVFEVVERVE--------ELRR-------------------- 964

  Fly   953 HLLRYLLKSG-YEASRIGVIAPYRAQV-----ELFKKLASKLDTDLECNTVDQFQGRDKNLIIYS 1011
               ::.:..| .:...|||:.||..||     ||.||..|    |:....|...||:...::..|
Human   965 ---KWPVAWGKLDDGSIGVVTPYADQVFRIRAELRKKRLS----DVNVERVLNVQGKQFRVLFLS 1022

  Fly  1012 CSKTGGDFSDMER--SREAEILEDQ------------RRLTVAITRAKNKLILLGDIKCLEQYGP 1062
            ..:|.......:.  .::.::|||.            :.|..|||||::.:.::||...|...|.
Human  1023 TVRTRHTCKHKQTPIKKKEQLLEDSTEDLDYGFLSNYKLLNTAITRAQSLVAVVGDPIALCSIGR 1087

  Fly  1063 FRQLFKHIPDRC 1074
            .|:.::.....|
Human  1088 CRKFWERFIALC 1099

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG2990NP_727386.1 Dna2 99..297 CDD:285859 45/236 (19%)
Cas4_I-A_I-B_I-C_I-D_II-B <283..415 CDD:294426 26/149 (17%)
TIGR00376 480..1069 CDD:273041 144/680 (21%)
P-loop_NTPase 636..859 CDD:304359 75/280 (27%)
AAA_12 815..1055 CDD:289832 52/264 (20%)
HELZXP_006722277.1 zf-CCCH 181..205 CDD:279036 2/23 (9%)
AAA_11 669..861 CDD:289831 57/212 (27%)
P-loop_NTPase 669..>766 CDD:304359 34/108 (31%)
DNA2 <785..1099 CDD:224037 75/367 (20%)
UvrD_C_2 868..1079 CDD:304668 51/264 (19%)
PHA03160 <1656..1815 CDD:165431
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1112
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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