DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2990 and Znfx1

DIOPT Version :9

Sequence 1:	NP_727386.1	Gene:	CG2990 / 31934	FlyBaseID:	FBgn0030170	Length:	1100	Species:	Drosophila melanogaster
Sequence 2:	NP_001028368.2	Gene:	Znfx1 / 98999	MGIID:	2138982	Length:	1909	Species:	Mus musculus

Alignment Length:	824	Identity:	171/824 - (20%)
Similarity:	282/824 - (34%)	Gaps:	299/824 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   348 LKEGLLREVASGRNEQRDLLM-LRNDLAYWLTREVAIPASKEDPLEQLPLPEPVYHHSACGNCAY 411
            ||:..|||:.:.|..:|.|.| ||.                                      ||
Mouse   682 LKQFTLRELRNKREFRRTLPMHLRR--------------------------------------AY 708

  Fly   412 NTICSSFAQKDSSLQ-------------LSDSHPLKKLMPQLLEHL-----SEAD--------HA 450
            .:|.:...:.:..||             |.:.|..|.:..|..|.|     .:||        |:
Mouse   709 MSIVTEMKESEQKLQEGAQTLECTMHGVLREQHLEKYISAQHWESLMSGPVQDADWVCVQPSKHS 773

  Fly   451 YVQHWCGLLALEEQHNRQSSHVRSF-WTKDPAEREKEGIAIRHLKLVKGQEVILEEGRYRQTL-E 513
            .:..|.||            .|.|| .:..||..|....|       :|:|.  |||....:| |
Mouse   774 MILEWLGL------------GVGSFTQSASPAGPENTAQA-------EGEEE--EEGEEEGSLIE 817

  Fly   514 LGEEADPSRDLSLSGFDLGEYVVISSTSRLAVAAGFIVSIEARRLDLRLERDL------SQRYSE 572
            :.|||    ||..:...:.|..|:....|.....|....:....|.:||::::      .::.:|
Mouse   818 IAEEA----DLIQADRVIEEEEVVRPRRRKKEENGTDQELAKMLLAMRLDQEVPGTTAGPEQATE 878

  Fly   573 ETFIIDKHDSQSFATFNFTNLGMLLSEGERFQELRDIIVAKKPPEQHKVLPKIILTKGAPILLNL 637
            |.                        |.:|.|:       ||...:.||
Mouse   879 EW------------------------ETQRGQK-------KKMKRRVKV---------------- 896

  Fly   638 NKVQQNAALRALTTSSHLLIKGLPGTGKTQTLVALVRLLHLLGKSVLITAQTHSAVDNLIMRLLP 702
                   .||.|.|.:.....|:..          |..|.|..:                .:|..
Mouse   897 -------ELRKLNTMTKAEANGIQD----------VWQLDLSSR----------------WQLYR 928

  Fly   703 FGLPMMRLGSGSRI---HKQ----LEEISEERLTKDCKTVEELEKALGQPSIVGVTCLGCG--HP 758
            ..|.|.:..:..||   .:|    .|.::|.||.:|...:::.|       :||:|..|..  ..
Mouse   929 LWLQMYQADTRRRILSYERQYRTWAERMAELRLQEDLHILKDAE-------VVGMTTTGAAKYRQ 986

  Fly   759 LFQRRQFDYCIVDEATQVLQPTVLRPLIH-CSKFVLVGDPEQLPPIVRSKE-ARQRGADETLFQR 821
            :.|:.:....||:||.:||:...:..|.. |...:|:||.:||.|.....: |:....:.:||:|
Mouse   987 ILQQVEPRIVIVEEAAEVLEAHTIATLSKACQHLILIGDHQQLRPSANVYDLAKNFNLEVSLFER 1051

  Fly   822 LDSEKATAV-LSLQYRMNKTITRLANELTYGGDLKCASDEVSGARFEVELLNEAPRWVQRALTTH 885
            |.......| |:.|:||...|.||                                     ||.|
Mouse  1052 LVKVNIPFVRLNYQHRMRPEIARL-------------------------------------LTPH 1079

  Fly   886 LEQAVTLINTGDCLERCQEFVYASQRLVDTCSSIEQSFSEDKDEIRKLTSKKRVSKYTNYCEAGI 950
            :.|  .|.|....| :.::....|..|.    .:|.:|.|  .||::..|      :.|..||..
Mouse  1080 IYQ--DLENHPSVL-KYEQIKGVSSNLF----FVEHNFPE--QEIQEGKS------HQNQHEAHF 1129

  Fly   951 VMHLLRYLLKSGYEASRIGVIAPYRAQVELFKKLAS-KLDTDLECNTVDQFQGRDKNLIIYSCSK 1014
            |:.|.:|||...|..|:|.::..|..|:...:||.. |....::.:.||::||.:.::|:.|..:
Mouse  1130 VVELCQYLLCQEYLPSQITILTTYTGQLFCLRKLMPVKTFAGIKVHVVDKYQGEENDIILLSLVR 1194

  Fly  1015 TGGDFSDMERSREAEI--LEDQRRLTVAITRAKNKLILLGDIKCL----------------EQYG 1061
            :         ::|.::  |:...|:.||::|||..:..:|:::.|                .|.|
Mouse  1195 S---------NQEGKVGFLQIPNRICVALSRAKKGMYCIGNMQMLAKVPLWSRIIHTLRENNQIG 1250

  Fly  1062 PFRQL-----------------FKHIPD-----RCRLKLEEGRM 1083
            |..:|                 |:.:|:     .|..:|..|.:
Mouse  1251 PSLRLCCQNHPETHTLVSKASDFQKVPEGGCSRPCEFRLACGHV 1294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2990	NP_727386.1	Dna2	99..297	CDD:285859
		Cas4_I-A_I-B_I-C_I-D_II-B	<283..415	CDD:294426	13/67 (19%)
		TIGR00376	480..1069	CDD:273041	136/643 (21%)
		P-loop_NTPase	636..859	CDD:304359	52/234 (22%)
		AAA_12	815..1055	CDD:289832	58/243 (24%)
Znfx1	NP_001028368.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..133
		EEXXEc_NFX1	591..>674	CDD:350694
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	787..813		9/34 (26%)
		AAA_11	<897..1031	CDD:404072	38/166 (23%)
		EEXXEc_NFX1	<971..1066	CDD:350694	27/101 (27%)
		SF1_C_Upf1	1068..1244	CDD:350195	51/236 (22%)
		NF-X1-zinc-finger	1365..1410	CDD:100116
		Keratin_B2	1425..1563	CDD:366678
		NF-X1-zinc-finger	1453..1497	CDD:100116
		PRK03918	<1597..>1808	CDD:235175
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900