Protein Alignment Dna2 and DNA2

DIOPT Version :10

• Sequence 1: NP_727386.1
• Gene: Dna2 / 31934
• FlyBaseID: FBgn0288690
• Length: 1100
• Species: Drosophila melanogaster
• Sequence 2: NP_012034.1
• Gene: DNA2 / 856569
• SGDID: S000001207
• Length: 1522
• Species: Saccharomyces cerevisiae
• Alignment Length: 1242
• Identity: 332/1242 - (26%)
• Similarity: 547/1242 - (44%)
• Gaps: 255/1242 - (20%)

  Fly    13 ENDNTDVTSSNPQKKFKEQLDFSSD--------------------EVENIDWGDNDDFDLALIAA 57
            |:.|......|.:.::....:||.|                    :::.::...:||.   .||.
Yeast   338 EDSNCQRIKKNEKIEYNSSDEFSDDSLIELLNETQTQVEPNTIEQDLDKVEKMVSDDL---RIAT 399

  Fly    58 MDSISNHRLELTKW-QRCEVVRL-------EQLPNRKGLKVHVKRI---SGGDPETADCQLLPPW 111
            ..::|.:.|..... .|..||||       .:||     |:..::|   ..|..|.:...:..||
Yeast   400 DSTLSAYALRAKSGAPRDGVVRLVIVSLRSVELP-----KIGTQKILECIDGKGEQSSVVVRHPW 459

  Fly   112 NCMPMQVGDTVSLL-GKWDPSAGCYVVDK-------EQGYCVSHPDFLISGTTVTGSLFCKRKSV 168
            ..:..:|||.:.:: ||...:......||       .....|.:||.|.|.|:|..|:.|.|:|:
Yeast   460 VYLEFEVGDVIHIIEGKNIENKRLLSDDKNPKTQLANDNLLVLNPDVLFSATSVGSSVGCLRRSI 524

  Fly   169 LQERF---RGLDSGNSVMVIGTLVHELLQKVLRQKLFDKK----HIQSALQEMLASSSLAHLL-- 224
            ||.:|   ||..|  .||.:|.:||||||..::.||...|    .|...|..:|.:.|.:.::
Yeast   525 LQMQFQDPRGEPS--LVMTLGNIVHELLQDSIKYKLSHNKISMEIIIQKLDSLLETYSFSIIICN 587

  Fly   225 ----YASNLIQVEMEDHLMKFIDPIVS--------FVAQYVKGEPPSVLLPEVYRGQIHEICDIE 277
                |...|:..|..::::.|::..||        .::...:.:|.|          |..:.|||
Yeast   588 EEIQYVKELVMKEHAENILYFVNKFVSKSNYGCYTSISGTRRTQPIS----------ISNVIDIE 642

  Fly   278 ENLWVPQLGLKGKVDVSVKVKNQRQREEIIPLELKTGRASFSMEHKGQLLLYQLMHSAQGRDTQS 342
            ||:|.|..||||.:|.:|:...:..::.|:|||:|||: |.|:.::.|.|:|.|:.:.:......
Yeast   643 ENIWSPIYGLKGFLDATVEANVENNKKHIVPLEVKTGK-SRSVSYEVQGLIYTLLLNDRYEIPIE 706

  Fly   343 GLLLYL-KEGLLREVASGRNEQRDLLMLRNDLAYWLTREVAIPASKEDPLEQLPLPEPVYHHSAC 406
            ..|||. ::..:.:..|..:..:.:||.||.::.....::.....:.....:||   |:...|:|
Yeast   707 FFLLYFTRDKNMTKFPSVLHSIKHILMSRNRMSMNFKHQLQEVFGQAQSRFELP---PLLRDSSC 768

  Fly   407 GNCAYNTICSSFAQKDSSLQLSDSHPLKKLMPQLLEHLSEADHAYVQHWCGLLALEEQHNRQS-S 470
            .:|.....|                   .::.:|||..:..:...|:   |...:...|..|: :
Yeast   769 DSCFIKESC-------------------MVLNKLLEDGTPEESGLVE---GEFEILTNHLSQNLA 811

  Fly   471 HVRSFWTK--DPAEREKEGIAI--RHLKLVKG----------------QEVI---LEEGRYRQTL 512
            :.:.|:||  |...:|:..|..  :.|.|:.|                .||:   ..||.|....
Yeast   812 NYKEFFTKYNDLITKEESSITCVNKELFLLDGSTRESRSGRCLSGLVVSEVVEHEKTEGAYIYCF 876

  Fly   513 ELGEEADPSRDLSLSGFDLGEYVVIS-STSRLAVAAG---FI------VSIEARRLDLRL----- 562
            ......:.|:.:..|.....::|:|| ......:..|   ||      :|::.:.|:.||
Yeast   877 SRRRNDNNSQSMLSSQIAANDFVIISDEEGHFCLCQGRVQFINPAKIGISVKRKLLNNRLLDKEK 941

  Fly   563 ---------ERDLSQ-----RYSEETFIIDKHDSQ---SFATFNFTNLGM-LLSEG-----ERFQ 604
                     |.:|.|     ..:..|:.|||:|.|   |.|.||..:|.: .:|.|     ||.:
Yeast   942 GVTTIQSVVESELEQSSLIATQNLVTYRIDKNDIQQSLSLARFNLLSLFLPAVSPGVDIVDERSK 1006

  Fly   605 ELRDIIVAKKPPEQHKVLPKIILTKGAP------------------ILLNLNKVQQNAALRALTT 651
            ..|.   .|:....:::|..:::...||                  ..||||  |:.|..:.:..
Yeast  1007 LCRK---TKRSDGGNEILRSLLVDNRAPKFRDANDDPVIPYKLSKDTTLNLN--QKEAIDKVMRA 1066

  Fly   652 SSHLLIKGLPGTGKTQTLVALVRLLHLLGKSVLITAQTHSAVDNLIMRLLPFGLPMMRLGSGSRI 716
            ..:.||.|:||||||..:..::::|...||.||:|:.|||||||::::|....:.:||||...::
Yeast  1067 EDYALILGMPGTGKTTVIAEIIKILVSEGKRVLLTSYTHSAVDNILIKLRNTNISIMRLGMKHKV 1131

  Fly   717 HKQLEEISEERLTKDCKTVEELEKALGQPSIVGVTCLGCGHPLF--QRRQFDYCIVDEATQVLQP 779
            |...::......:  .|:..:....:...|:|..||||....||  ..:.|||.|:|||:|:..|
Yeast  1132 HPDTQKYVPNYAS--VKSYNDYLSKINSTSVVATTCLGINDILFTLNEKDFDYVILDEASQISMP 1194

  Fly   780 TVLRPLIHCSKFVLVGDPEQLPPIVRSKEARQRGADETLFQRLDSE--KATAVLSLQYRMNKTIT 842
            ..|.||.:.::|::|||..||||:|::..||..|.:|:||:....:  ::.|.|:|||||...|.
Yeast  1195 VALGPLRYGNRFIMVGDHYQLPPLVKNDAARLGGLEESLFKTFCEKHPESVAELTLQYRMCGDIV 1259

  Fly   843 RLANELTYGGDLKCASDEVSGARFEVELLNEAPRWVQRALTTH--LEQAVTLINTGDCLERCQEF 905
            .|:|.|.|...|||.::||.....|:.:.....|:...:..:.  ||         |.||..::.
Yeast  1260 TLSNFLIYDNKLKCGNNEVFAQSLELPMPEALSRYRNESANSKQWLE---------DILEPTRKV 1315

  Fly   906 VYASQRLVDTCSS-IEQSFSEDKDEIRKLTSKKRVSKYTNYCEAGIVMHLLRYLLKSGYEASRIG 969
            |:.:   .|.|.. ||||   :||.|            ||:.||.:.:..:..:|.||.....||
Yeast  1316 VFLN---YDNCPDIIEQS---EKDNI------------TNHGEAELTLQCVEGMLLSGVPCEDIG 1362

  Fly   970 VIAPYRAQVELFKKLASKLDTD-LECNTVDQFQGRDKNLIIYSCSKTGGDFSDMERSREAEILED 1033
            |:..||||:.|.||:.:|...| ||..|.||||||||..||.|..:.....:.      ..:|::
Yeast  1363 VMTLYRAQLRLLKKIFNKNVYDGLEILTADQFQGRDKKCIIISMVRRNSQLNG------GALLKE 1421

  Fly  1034 QRRLTVAITRAKNKLILLGD-------------IKCLEQ----YGPFRQ-LFKH-IPDRCRLKLE 1079
            .||:.||:||||:|||::|.             :..||:    |...:. |:|: .|||.. .::
Yeast  1422 LRRVNVAMTRAKSKLIIIGSKSTIGSVPEIKSFVNLLEERNWVYTMCKDALYKYKFPDRSN-AID 1485

  Fly  1080 EGRMEFG 1086
            |.|...|
Yeast  1486 EARKGCG 1492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dna2	NP_727386.1	DNA2_N-like	153..378	CDD:411722	72/246 (29%)
		DEXXQc_DNA2	636..836	CDD:350799	73/203 (36%)
		AAA_12	815..1055	CDD:463780	83/258 (32%)
DNA2	NP_012034.1	Dna2	444..662	CDD:462565	66/229 (29%)
		Cas4	<645..779	CDD:441077	36/156 (23%)
		TIGR00376	<1049..1464	CDD:273041	152/451 (34%)
		DEXXQc_DNA2	1052..1253	CDD:350799	74/204 (36%)