DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2990 and NAM7

DIOPT Version :9

Sequence 1:	NP_727386.1	Gene:	CG2990 / 31934	FlyBaseID:	FBgn0030170	Length:	1100	Species:	Drosophila melanogaster
Sequence 2:	NP_013797.1	Gene:	NAM7 / 855104	SGDID:	S000004685	Length:	971	Species:	Saccharomyces cerevisiae

Alignment Length:	809	Identity:	191/809 - (23%)
Similarity:	319/809 - (39%)	Gaps:	224/809 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   362 EQRDLLMLRNDLAYWLTREVAIPASKEDPLEQLPLPEPVYHHSACGNCAYNTICSSFAQKDSSLQ 426
            |.|.||.       |:..:   |..:|....:|..|..:....|...          :.||:::.
Yeast   170 EDRQLLS-------WVAEQ---PTEEEKLKARLITPSQISKLEAKWR----------SNKDATIN 214

  Fly   427 LSDSHPLKKLMPQLLEHLSEADHAYVQHWCGLLALEEQHNRQSSHVRSFWTKDPAEREKEGIAIR 491
            ..|:...::.:|.||....:| :.|.:.:..|:.||..:::|.               ||..|:.
Yeast   215 DIDAPEEQEAIPPLLLRYQDA-YEYQRSYGPLIKLEADYDKQL---------------KESQALE 263

  Fly   492 HLKLVKGQEVILEEGRYRQTLELGEEADPSRDLSLSGFDLGEYVVIS-STSRLAVAAGFIVSI-- 553
            |:.:                         |..|:|:...|..:.:.: .::.|.||.|..:.:
Yeast   264 HISV-------------------------SWSLALNNRHLASFTLSTFESNELKVAIGDEMILWY 303

  Fly   554 --------EARRLDLRLERDLSQRYSEETFIIDKHDSQ----SFATFNFTNLGMLLSEGERFQEL 606
                    |.|...:||....     ::||.::...|:    :..|..||  ...:.:|..:..:
Yeast   304 SGMQHPDWEGRGYIVRLPNSF-----QDTFTLELKPSKTPPPTHLTTGFT--AEFIWKGTSYDRM 361

  Fly   607 RDII----VAKKPPE--------QHKV--------LPKIILTKGAPILLNLNKVQQNAALRALTT 651
            :|.:    :.||...        .|:|        |||..   ..|....||..|.||.
Yeast   362 QDALKKFAIDKKSISGYLYYKILGHQVVDISFDVPLPKEF---SIPNFAQLNSSQSNAV------ 417

  Fly   652 SSHL------LIKGLPGTGKTQTLVALVRLLHLLGKS-VLITAQTHSAVDNLIMRLLPFGLPMMR 709
             ||:      ||:|.||||||.|...:|..|..:.|. :|:.|.::.|||:|..:|...||.::|
Yeast   418 -SHVLQRPLSLIQGPPGTGKTVTSATIVYHLSKIHKDRILVCAPSNVAVDHLAAKLRDLGLKVVR 481

  Fly   710 LGSGSR-----------IHK------------------QLEEISEERLTKDCKTVEELE-KALGQ 744
            |.:.||           :|.                  ::.|:|.....:..|.|.:.| :.|.:
Yeast   482 LTAKSREDVESSVSNLALHNLVGRGAKGELKNLLKLKDEVGELSASDTKRFVKLVRKTEAEILNK 546

  Fly   745 PSIVGVTCLGCGHPLFQRRQFDYCIVDEATQVLQPTVLRPLIHCSK-FVLVGDPEQLPPIVRSKE 808
            ..:|..||:|.|......: |...::||:||..:|..|.|::..:| .:||||.:||.|::..::
Yeast   547 ADVVCCTCVGAGDKRLDTK-FRTVLIDESTQASEPECLIPIVKGAKQVILVGDHQQLGPVILERK 610

  Fly   809 ARQRGADETLFQRLDSEKATAV-LSLQYRMNKTITRLANELTYGGDLKCASDEVSGARFEVELL- 871
            |...|..::||:||.|.....: |.:|||||..::...:.:.|.|.|:      :|...|...:
Yeast   611 AADAGLKQSLFERLISLGHVPIRLEVQYRMNPYLSEFPSNMFYEGSLQ------NGVTIEQRTVP 669

  Fly   872 NEAPRWVQRALTTHLEQAVTLINTGDCLERCQEFVYASQRLVDTCSSIEQSFSEDKDEIRKLTSK 936
            |....|..|.:     ..:...|.|                              ::||     .
Yeast   670 NSKFPWPIRGI-----PMMFWANYG------------------------------REEI-----S 694

  Fly   937 KRVSKYTNYCEAGIVMHLLRYLLKSGYEASRIGVIAPY---RAQVELFKKLASKLDTDL----EC 994
            ...:.:.|..||.....::..|.:.|.:..:||||.||   ||.:..:.::...||.||    |.
Yeast   695 ANGTSFLNRIEAMNCERIITKLFRDGVKPEQIGVITPYEGQRAYILQYMQMNGSLDKDLYIKVEV 759

  Fly   995 NTVDQFQGRDKNLIIYSCSKTGGDFSDMERSREAE---ILEDQRRLTVAITRAKNKLILLGDIKC 1056
            .:||.||||:|:.||.||          .|:.|.:   .|.|.|||.|.:||||..|::||:.:.
Yeast   760 ASVDAFQGREKDYIILSC----------VRANEQQAIGFLRDPRRLNVGLTRAKYGLVILGNPRS 814

  Fly  1057 LEQYGPFRQLFKHIPDR-CRLKLEEGRME 1084
            |.:...:..|..|..:: |   |.||.::
Yeast   815 LARNTLWNHLLIHFREKGC---LVEGTLD 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2990	NP_727386.1	Dna2	99..297	CDD:285859
		Cas4_I-A_I-B_I-C_I-D_II-B	<283..415	CDD:294426	10/52 (19%)
		TIGR00376	480..1069	CDD:273041	164/673 (24%)
		P-loop_NTPase	636..859	CDD:304359	77/261 (30%)
		AAA_12	815..1055	CDD:289832	67/251 (27%)
NAM7	NP_013797.1	DNA2	84..851	CDD:224037	191/809 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810