DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG2990 and HELZ2

DIOPT Version :9

Sequence 1:NP_727386.1 Gene:CG2990 / 31934 FlyBaseID:FBgn0030170 Length:1100 Species:Drosophila melanogaster
Sequence 2:XP_024307774.1 Gene:HELZ2 / 85441 HGNCID:30021 Length:2677 Species:Homo sapiens


Alignment Length:556 Identity:122/556 - (21%)
Similarity:197/556 - (35%) Gaps:171/556 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   615 PPEQHKVLPKIILTKGAPILLNLNKVQQNAALRALTTSSHLLIKGLPGTGKTQTLVALVRLLH-- 677
            |..:||:.|                 .||.|:|........:|:|.||||||...:.:|...|  
Human  2175 PGGRHKLNP-----------------SQNVAVREALEKPFTVIQGPPGTGKTIVGLHIVFWFHKS 2222

  Fly   678 ----------------LLGKSVLITAQTHSAVDNLI------MRLLPFGL----------PMMRL 710
                            |.|..:|....::.:||.|.      |.|.|..:          |:.|:
Human  2223 NQEQVQPGGPPRGEKRLGGPCILYCGPSNKSVDVLAGLLLRRMELKPLRVYSEQAEASEFPVPRV 2287

  Fly   711 GSGSRIHKQLEE---------------------------------------ISEERLTKDCKTVE 736
            ||...:.|...|                                       .|.|.|....|.:.
Human  2288 GSRKLLRKSPREGRPNQSLRSITLHHRIRQAPNPYSSEIKAFDTRLQRGELFSREDLVWYKKVLW 2352

  Fly   737 ELEK-ALGQPSIVGVTCLGCGH----PLFQRRQFDYCIVDEATQVLQPTVLRPLI---HCSKFVL 793
            |..| .|.:..::..|| .|..    .:...||.   :||||....:|..|.||:   ...|.||
Human  2353 EARKFELDRHEVILCTC-SCAASASLKILDVRQI---LVDEAGMATEPETLIPLVQFPQAEKVVL 2413

  Fly   794 VGDPEQLPPIVRSKEARQRGADETLFQRLDSEKATAVLSLQYRMNKTITRLANELTYGGDLKCAS 858
            :||.:||.|:|:::..:..|.|.:||:|...:  ..:|..||||::.|....:...|...||   
Human  2414 LGDHKQLRPVVKNERLQNLGLDRSLFERYHED--AHMLDTQYRMHEGICAFPSVAFYKSKLK--- 2473

  Fly   859 DEVSGARFEVELLNEAPRWVQRALTTHLEQAVTLINTGDCLERCQEFVYASQRLVDTCSSIEQSF 923
             ...|.|....:|..|.:.....:..|::.                  :....||.|....|.| 
Human  2474 -TWQGLRRPPSVLGHAGKESCPVIFGHVQG------------------HERSLLVSTDEGNENS- 2518

  Fly   924 SEDKDEIRKLTSKKRVSKYTNYCEAGIVMHLLRYLLKSGYEASRIGVIAPYRAQV-ELFKKLASK 987
               |..:.::....|::|              :..|....|...|.|:.||.||. |:.|.|..:
Human  2519 ---KANLEEVAEVVRITK--------------QLTLGRTVEPQDIAVLTPYNAQASEISKALRRE 2566

  Fly   988 LDTDLECNTVDQFQGRDKNLIIYS----CSKTGGDFSDMERSREAEILE-------DQRRLTVAI 1041
            ....:..:::.:.||.:...::.|    |:|     ||:::......|:       |..::.||:
Human  2567 GIAGVAVSSITKSQGSEWRYVLVSTVRTCAK-----SDLDQRPTKSWLKKFLGFVVDPNQVNVAV 2626

  Fly  1042 TRAKNKLILLGD---IKCLEQYGPFRQLFKHIPDRC 1074
            |||:..|.|:||   ::|.       .|::.:.|.|
Human  2627 TRAQEGLCLIGDHLLLRCC-------PLWRSLLDFC 2655

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG2990NP_727386.1 Dna2 99..297 CDD:285859
Cas4_I-A_I-B_I-C_I-D_II-B <283..415 CDD:294426
TIGR00376 480..1069 CDD:273041 120/549 (22%)
P-loop_NTPase 636..859 CDD:304359 72/303 (24%)
AAA_12 815..1055 CDD:289832 55/254 (22%)
HELZ2XP_024307774.1 ZnF_U1 39..69 CDD:197732
AAA_11 541..705 CDD:331082
UvrD_C_2 715..915 CDD:328976
RNB 1334..1693 CDD:214935
AAA_11 2180..2427 CDD:315699 60/267 (22%)
AAA_12 2434..2639 CDD:315700 54/251 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1112
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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