Protein Alignment CG2990 and SEN1

DIOPT Version :9

• Sequence 1: NP_727386.1
• Gene: CG2990 / 31934
• FlyBaseID: FBgn0030170
• Length: 1100
• Species: Drosophila melanogaster
• Sequence 2: NP_013534.3
• Gene: SEN1 / 851150
• SGDID: S000004422
• Length: 2231
• Species: Saccharomyces cerevisiae
• Alignment Length: 1142
• Identity: 234/1142 - (20%)
• Similarity: 411/1142 - (35%)
• Gaps: 370/1142 - (32%)

  Fly   188 LVHE----LLQKVLRQ--------KLFDKKHIQSALQEMLASSSLAHLLYASNLIQVEMEDHLMK 240
            ::|:    ||..||..        :|.|:..::|.::.::::|.|||            |.| :|
Yeast   823 ILHDQTKNLLLNVLETFKNMLYWLRLSDEVLLESCVRLIISTSDLAH------------EKH-VK 874

  Fly   241 FIDPIVSFVAQYV-KGEPPSVLLPEVYRGQIHEICDIEENLWVPQLGLKGKV-------DVSVKV 297
            ..|.:|..:|:|. |.:..|..|.|....:|.:               |.|:       :|:.:.
Yeast   875 VDDSLVEMMAKYASKAKRFSNKLTEQQASEILQ---------------KAKIFNKALTEEVATEA 924

  Fly   298 KNQRQREEIIPL------------------ELKTGRASFSMEHKGQLLLYQLMHS--------AQ 336
            :|.|:.:|:..|                  .|.:..||.|.|.:...|..:.:.|        ||
Yeast   925 ENYRKEKELSRLGKVIDLTDSVPASPSLSPSLSSTIASSSAESRADYLQRKALSSSITGRPRVAQ 989

  Fly   337 GRDTQSGLLLYLKEGLLREVAS----GRNEQRDLLMLRNDLAYWLTREVAIPASKEDPLEQLPLP 397
            .:.|..|.........|.....    .:.|...:.:|.|.:.:                   |..
Yeast   990 PKITSFGTFQSSANAKLHRTKPVKPLSKMELARMQLLNNRVVH-------------------PPS 1035

  Fly   398 EPVYHHSACGNCAYNTICSS-------------FA---QKDSSLQLSD-------SHPLKKLMPQ 439
            .|.:|..:.|....|...||             ||   .|...:|..|       .....:|..|
Yeast  1036 APAFHTKSRGLSNKNDDSSSEESDNDIESARELFAIAKAKGKGIQTVDINGKVVKRQTAAELAKQ 1100

  Fly   440 LLEHLSEADHAYVQHWCGLLALEEQHNRQS-----------SHVRSFWTKDPAEREK-------- 485
            .|||:.:..:..:.....:: |:..:.|.|           |.|:.|: ..||:.:|
Yeast  1101 ELEHMRKRLNVDMNPLYEII-LQWDYTRNSEYPDDEPIGNYSDVKDFF-NSPADYQKVMKPLLLL 1163

  Fly   486 ---EGIA-------IRHLKLVKGQEVILEE------GRYRQTL-ELG-EEAD-----------PS 521
               :|:.       .:...::.|....:.:      ...:|.: :.| .|:|           |.
Yeast  1164 ESWQGLCSSRDREDYKPFSIIVGNRTAVSDFYDVYASVAKQVIQDCGISESDLIVMAYLPDFRPD 1228

  Fly   522 RDLSLSGFDLGEYVVISSTSRLAVAAGFIVSIEARRLDLRLERDLSQRYSEETFIIDKHDSQSFA 586
            :.||...|...::..::....|....|..|.:     .||:.|:    :|...|:..:.:.....
Yeast  1229 KRLSSDDFKKAQHTCLAKVRTLKNTKGGNVDV-----TLRIHRN----HSFSKFLTLRSEIYCVK 1284

  Fly   587 TFNFTNLGMLLS--EGERFQEL-RDIIVAKKPPEQHKVLPKIILTKGAPILLNLNKVQQNAALRA 648
            ....|.:....|  ||..:.:| ..|:.||..|..:....:|...|.:   ..||..|..|.:.:
Yeast  1285 VMQMTTIEREYSTLEGLEYYDLVGQILQAKPSPPVNVDAAEIETVKKS---YKLNTSQAEAIVNS 1346

  Fly   649 LTTSSHLLIKGLPGTGKTQTLVALVRLL------------------------HLLGK-SVLITAQ 688
            ::.....||:|.||||||:|::.::...                        .||.| .:||.|.
Yeast  1347 VSKEGFSLIQGPPGTGKTKTILGIIGYFLSTKNASSSNVIKVPLEKNSSNTEQLLKKQKILICAP 1411

  Fly   689 THSAVDNLIMRLL---------PFGLPMMRLGSGSRIH-----KQLEEISEERLTK---DCKTVE 736
            :::|||.:.:||.         .|...::|:|....::     ..|||:.::|:.:   :.:|..
Yeast  1412 SNAAVDEICLRLKSGVYDKQGHQFKPQLVRVGRSDVVNVAIKDLTLEELVDKRIGERNYEIRTDP 1476

  Fly   737 ELEKAL------------------GQP-------------------------------------- 745
            |||:..                  |.|
Yeast  1477 ELERKFNNAVTKRRELRGKLDSESGNPESPMSTEDISKLQLKIRELSKIINELGRDRDEMREKNS 1541

  Fly   746 ---------------------SIVGVTCLGCGHPLFQRR--QFDYCIVDEATQVLQPTVLRPLIH 787
                                 .|:..|..|..|.:....  :||..|:|||.|..:.:.:.||.:
Yeast  1542 VNYRNRDLDRRNAQAHILAVSDIICSTLSGSAHDVLATMGIKFDTVIIDEACQCTELSSIIPLRY 1606

  Fly   788 CSK-FVLVGDPEQLPPIVRSKEARQRGADETLFQRLDSEKATAVLSLQYRMNKTITRLANELTYG 851
            ..| .::||||.||||.|.|..|.....:::||.|::...:..:|.:||||:.:|::..:...|.
Yeast  1607 GGKRCIMVGDPNQLPPTVLSGAASNFKYNQSLFVRMEKNSSPYLLDVQYRMHPSISKFPSSEFYQ 1671

  Fly   852 GDLKCASDEVSGARFEVELLNEAPRWVQRALTTHLEQAVTLINTGDCLERCQEFVYASQRLVDTC 916
            |.||....        :::||:.| |.|      ||.                  .|..:..|..
Yeast  1672 GRLKDGPG--------MDILNKRP-WHQ------LEP------------------LAPYKFFDII 1703

  Fly   917 SSIEQSFSEDKDEIRKLTSKKRVSKYTNYCEAGIVMHLLRYLLKSGYE-----ASRIGVIAPYRA 976
            |.            |:..:.|.:| |||..|..:.:.|:.||.:. ::     ..:||:|:|||.
Yeast  1704 SG------------RQEQNAKTMS-YTNMEEIRVAIELVDYLFRK-FDNKIDFTGKIGIISPYRE 1754

  Fly   977 QVELFKK-----LASKLDTDLECNTVDQFQGRDKNLIIYSCSKTGGDFSDMERSREAEILEDQRR 1036
            |::..:|     ....::..::.||:|.|||::|.:|:.||.:     :|..:| ....|:|.||
Yeast  1755 QMQKMRKEFARYFGGMINKSIDFNTIDGFQGQEKEIILISCVR-----ADDTKS-SVGFLKDFRR 1813

  Fly  1037 LTVAITRAKNKLILLGDIKCLEQYGPFRQLFKHIPDR 1073
            :.||:||||..:.:||..:.|.:...:|.|.:...||
Yeast  1814 MNVALTRAKTSIWVLGHQRSLAKSKLWRDLIEDAKDR 1850

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2990	NP_727386.1	Dna2	99..297	CDD:285859	27/128 (21%)
		Cas4_I-A_I-B_I-C_I-D_II-B	<283..415	CDD:294426	27/168 (16%)
		TIGR00376	480..1069	CDD:273041	163/760 (21%)
		P-loop_NTPase	636..859	CDD:304359	76/344 (22%)
		AAA_12	815..1055	CDD:289832	65/249 (26%)
SEN1	NP_013534.3	SEN1_N	106..859	CDD:403815	8/35 (23%)
		DNA2	1006..1858	CDD:224037	192/931 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810