DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2990 and Helz

DIOPT Version :9

Sequence 1:	NP_727386.1	Gene:	CG2990 / 31934	FlyBaseID:	FBgn0030170	Length:	1100	Species:	Drosophila melanogaster
Sequence 2:	NP_938040.1	Gene:	Helz / 78455	MGIID:	1925705	Length:	1965	Species:	Mus musculus

Alignment Length:	1209	Identity:	246/1209 - (20%)
Similarity:	391/1209 - (32%)	Gaps:	464/1209 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 VTSSNPQ---KKFKEQLDFSSDEVENIDWGDNDDFDLALIAAMDSISNHRLELTKWQRCEVVRLE 80
            :|||...   |:|.||                   .:....|..:.::.:.||.:||:....||.
Mouse   175 ITSSEEYTLCKRFLEQ-------------------GICRYGAQCTSAHSQEELAEWQKRYASRLI 220

  Fly    81 QLPNRKGLKVHVKRISGGDPETADCQLLPPWNCMPMQVGDTVSLLGKWDPSAGCYVVDKE--QGY 143
            :|..:.    ..|::||...||                     |:.||..|.....|..|  :|.
Mouse   221 KLKQQS----ENKQLSGSYMET---------------------LIEKWMSSLSPEKVLSECIEGV 260

  Fly   144 CVSH-PDFLI------SGTTVTGSLFCK------RKSVLQERFR------GLDSGNSVMVIGTLV 189
            .|.| ||..:      |..|.|.:|.||      |.::|.:..|      .:.:|:|...:...|
Mouse   261 QVEHSPDLSVTVNTKKSHQTWTFALTCKPARMLYRVALLYDAHRPHFSIIAISAGDSTTQVSQEV 325

  Fly   190 HELLQKVLRQKLFDKKHIQSALQEMLASSSLAHLLY----ASN--------------------LI 230
            .|..|:.:..|              :|.:.|.|.:|    |.|                    |:
Mouse   326 PENCQEWIGGK--------------MAQNGLDHYVYKVGIAFNTEIFGTFRQTIVFDFGLEPVLM 376

  Fly   231 QVEMED--------HLMKFIDPIVSFVAQY-------VKGEPPSVLLPEVYRGQIHEICDIEENL 280
            |..|.|        :||.....:|:...::       |..||             :|..|:|::|
Mouse   377 QRVMIDAASTEDLEYLMHAKRQLVTTAKRWDSSSKTIVDFEP-------------NETTDLEKSL 428

  Fly   281 WV--------PQLGLKGKVDVSVKVKNQRQR-------EEIIPLELKTGRASFSMEHKGQLLLYQ 330
            .:        .||..:..:|.|:...|.:.|       |||...: :..|  |:::.:.|:|...
Mouse   429 LIRYQIPLSADQLFTQSVLDKSLTKTNYQARLHDLLYIEEIAQYK-EVSR--FNLKVQLQILASF 490

  Fly   331 LMHSAQG--RDTQSGLL---LYLKEGLLREVASGRNEQRDLLMLRNDLAYWLTREVAIPASKEDP 390
            ::....|  :..|:|.|   ..|.|.|..:..:||     |:|.|.:..|.|      |..||..
Mouse   491 MLTGVSGGAKYAQNGQLFGRFKLTETLSEDTLAGR-----LVMTRVNAVYLL------PVPKEKL 544

  Fly   391 LEQLPLPEPVYHHSACGNCAYNTICSSFAQKDSSLQLSDSHPLKKLMPQLLEHLSEADHAYVQHW 455
            ::.....|.||                                            ||
Mouse   545 VQSQGTKEKVY--------------------------------------------EA-------- 557

  Fly   456 CGLLALEEQHNRQSSHVRSFWTKDPAEREKEGIAIRHLKLVKGQEVILEEGRYRQTLELGEEAD- 519
                .:||:            |||                    .|.|...|     |..||..
Mouse   558 ----TIEEK------------TKD--------------------YVFLRISR-----ECCEELSL 581

  Fly   520 -PSRDLSLSGFDLGEYVVISSTSRLAVAAGFIVSIEARRLDLRLERDLSQRYSEETFIIDKHDSQ 583
             |..|:.:.                       :..:..||.|          .|..:.:|:
Mouse   582 RPDCDIQVE-----------------------LQFQLNRLPL----------CEMHYALDR---- 609

  Fly   584 SFATFNFTNLGMLLSEGERFQELRDIIVAKKPPEQHKVLPKIILTKGAPILLN----------LN 638
                                  ::|..|         :.|.|.:|...|...|          ||
Mouse   610 ----------------------IKDNAV---------LFPDISMTPTIPWSPNRQWDEQLDPRLN 643

  Fly   639 KVQQNAALRALTTSSHL-----LIKGLPGTGKTQTLVALVRLLHLLGKS----VLITAQTHSAVD 694
            ..|:.|.| |:||...:     ||.|..|||||.||....:  |:|.:.    :||...::||.|
Mouse   644 AKQKEAVL-AITTPLSIQLPPVLIIGPYGTGKTFTLAQAAK--HILQQQETSRILICTHSNSAAD 705

  Fly   695 NLIMRLL-PF---GLPM---MRLGSGSR----IHKQLEE---ISEERLTKDCKTVEELEKALGQP 745
            ..|...| |:   |.|.   :|:...:|    :|..:.:   ||..:.|......|::.|    .
Mouse   706 LYIKDYLHPYVEAGNPQARPLRVYFRNRWVKTVHPVVHQYCLISSTQSTFQMPQKEDILK----H 766

  Fly   746 SIVGVT-------CLGCGHPLFQRRQFDYCIVDEATQVLQPTVLRPLIHCSK---FVLVGDPEQL 800
            .:|.||       |.....|.|    |.:.::|||.|.::...:.||...:|   .||.||..||
Mouse   767 RVVVVTLSTSQYLCQLDLEPGF----FTHVLLDEAAQAMECETIMPLALATKNTRIVLAGDHMQL 827

  Fly   801 PPIVRSKEARQRGADETLFQRL----DSEKATAVLSLQ-YRMNKTITRLANELTYGGDLKCASDE 860
            .|.|.|:.||:|....:|..||    .:|....:|..: ||.::.|....:||.|.|.|..:..:
Mouse   828 SPFVYSEFARERNLHVSLLDRLYEHYPAEFPCRILLCENYRSHEAIINYTSELFYEGKLMASGKQ 892

  Fly   861 VSGARFEVELLNEAPRWVQRALTTHLEQAVTLINTGDCLERCQEFVYASQRLVDTCSSIEQSFSE 925
            .:...|          :.....|...|         |..|:.....|.:..:.:....:|
Mouse   893 PAHKDF----------YPLTFFTARGE---------DVQEKNSTAFYNNAEVFEVVERVE----- 933

  Fly   926 DKDEIRKLTSKKRVSKYTNYCEAGIVMHLLRYLLKSG-YEASRIGVIAPYRAQV-----ELFKKL 984
               |:|:                       ::.:..| .:...|||:.||..||     ||.||.
Mouse   934 ---ELRR-----------------------KWPVAWGKLDDGSIGVVTPYADQVFRIRAELRKKR 972

  Fly   985 ASKLDTDLECNTVDQFQGRDKNLIIYSCSKTGGDFSDMER--SREAEILEDQ------------R 1035
            .|    |:....|...||:...::..|..:|.......:.  .::.::|||.            :
Mouse   973 LS----DVNVERVLNVQGKQFRVLFLSTVRTRHTCKHKQTPIKKKEQLLEDSTEDLDYGFLSNYK 1033

  Fly  1036 RLTVAITRAKNKLILLGDIKCLEQYGPFRQLFKHIPDRC 1074
            .|..|||||::.:.::||...|...|..|:.::.....|
Mouse  1034 LLNTAITRAQSLVAVVGDPVALCSIGRCRKFWERFIALC 1072

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2990	NP_727386.1	Dna2	99..297	CDD:285859	52/265 (20%)
		Cas4_I-A_I-B_I-C_I-D_II-B	<283..415	CDD:294426	33/143 (23%)
		TIGR00376	480..1069	CDD:273041	139/658 (21%)
		P-loop_NTPase	636..859	CDD:304359	78/270 (29%)
		AAA_12	815..1055	CDD:289832	52/264 (20%)
Helz	NP_938040.1	zf-CCCH	181..204	CDD:366217	5/41 (12%)
		DEXXQc_HELZ	641..868	CDD:350835	69/237 (29%)
		DEAA box	795..798		2/2 (100%)
		SF1_C_Upf1	869..1069	CDD:350195	48/253 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1117..1136
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1249..1351
		Atrophin-1	1262..>1416	CDD:367360
		Amelogenin	<1338..>1414	CDD:197891
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1361..1380
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1389..1450
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1464..1492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1632..1656
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1744..1965
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810