DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2990 and UPF1

DIOPT Version :9

Sequence 1:	NP_727386.1	Gene:	CG2990 / 31934	FlyBaseID:	FBgn0030170	Length:	1100	Species:	Drosophila melanogaster
Sequence 2:	XP_016882594.1	Gene:	UPF1 / 5976	HGNCID:	9962	Length:	1137	Species:	Homo sapiens

Alignment Length:	790	Identity:	194/790 - (24%)
Similarity:	318/790 - (40%)	Gaps:	210/790 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   387 KEDP---LEQLPLP----EPVYHHSACGNCAYNTICSSFAQKDSSLQLSDSHPLKKLMPQLLEHL 444
            ||:|   ||.|..|    ||                     :...|:..|::..:.:...|::
Human   270 KENPSATLEDLEKPGVDEEP---------------------QHVLLRYEDAYQYQNIFGPLVK-- 311

  Fly   445 SEADHAYVQHWCGLLALEEQHNRQSSHVR----------SFWTKDPAEREKEGIAI---RHLKLV 496
            .|||:.        ..|:|...:.:..||          :::|....:...|.:.|   |.::|:
Human   312 LEADYD--------KKLKESQTQDNITVRWDLGLNKKRIAYFTLPKTDSGNEDLVIIWLRDMRLM 368

  Fly   497 KGQEVILEEGRYRQTLE-----LGEEADPSRDLSLSGF-DLGEYVVISSTSRLA----VAAGFIV 551
            :|.|:.|   ||:..|.     :|.......:.:|:.. |.|:.:.|...|.:.    |...|.|
Human   369 QGDEICL---RYKGDLAPLWKGIGHVIKVPDNANLTQHTDYGDEIAIELRSSVGAPVEVTHNFQV 430

  Fly   552 SI--EARRLDLRLERDLSQRYSEETFIIDKHDSQSFATFNFTNLGMLLSEGERFQELRDIIVAKK 614
            ..  ::...| |::..|      :||.:|:.....:.....  ||         .|:.|:|:..:
Human   431 DFVWKSTSFD-RMQSAL------KTFAVDETSVSGYIYHKL--LG---------HEVEDVIIKCQ 477

  Fly   615 PPEQHKVLPKIILTKGAPILLNLNKVQQNAALRALTTSSHLLIKGLPGTGKTQTLVALVRLLHLL 679
                   |||....:|.|   :||. .|..|::.:......||:|.||||||.|...:|..|...
Human   478 -------LPKRFTAQGLP---DLNH-SQVYAVKTVLQRPLSLIQGPPGTGKTVTSATIVYHLARQ 531

  Fly   680 GKS-VLITAQTHSAVDNLIMRLLPFGLPMMRLGSGSR-----------IHKQLEEI--------- 723
            |.. ||:.|.::.|||.|..::...||.::||.:.||           :|.|:..:
Human   532 GNGPVLVCAPSNIAVDQLTEKIHQTGLKVVRLCAKSREAIDSPVSFLALHNQIRNMDSMPELQKL 596

  Fly   724 ------------SEERLTKDCKTVEELEKALGQPSIVGVTCLGCGHPLFQRRQFDYCIVDEATQV 776
                        ::|:..:..|...|.| .|....::..||:|.|.|...:.||...::||:||.
Human   597 QQLKDETGELSSADEKRYRALKRTAERE-LLMNADVICCTCVGAGDPRLAKMQFRSILIDESTQA 660

  Fly   777 LQPTVLRPLIHCSK-FVLVGDPEQLPPIVRSKEARQRGADETLFQRLDSEKATAV-LSLQYRMNK 839
            .:|..:.|::..:| .:||||..||.|:|..|:|.:.|..::||:||.......: |.:||||:.
Human   661 TEPECMVPVVLGAKQLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLVVLGIRPIRLQVQYRMHP 725

  Fly   840 TITRLANELTYGGDLK---CASDEV-SGARFEVELLNEAPRWVQRALTTHLEQAVTLINTGDCLE 900
            .::...:.:.|.|.|:   .|:|.| .|..|:         |.|.....
Human   726 ALSAFPSNIFYEGSLQNGVTAADRVKKGFDFQ---------WPQPDKPM---------------- 765

  Fly   901 RCQEFVYASQRLVDTCSSIEQSFSEDKDEIRKLTSKKRVSKYTNYCEAGIVMHLLRYLLKSGYEA 965
                |.|.:|...:..||                    .:.|.|..||..|..:...|||:|.:.
Human   766 ----FFYVTQGQEEIASS--------------------GTSYLNRTEAANVEKITTKLLKAGAKP 806

  Fly   966 SRIGVIAPYRAQ-------VELFKKLASKLDTDLECNTVDQFQGRDKNLIIYSCSKTGGDFSDME 1023
            .:||:|.||..|       ::....|.:||..::|..:||.||||:|:.||.||          .
Human   807 DQIGIITPYEGQRSYLVQYMQFSGSLHTKLYQEVEIASVDAFQGREKDFIILSC----------V 861

  Fly  1024 RSREAE---ILEDQRRLTVAITRAKNKLILLGDIKCLEQYGPFRQLFKHIPDRCRL------KLE 1079
            |:.|.:   .|.|.|||.||:|||:..:|::|:.|.|.:...:..|..:..::..|      .|.
Human   862 RANEHQGIGFLNDPRRLNVALTRARYGVIIVGNPKALSKQPLWNHLLNYYKEQKVLVEGPLNNLR 926

  Fly  1080 EGRMEFGWQR 1089
            |..|:|...|
Human   927 ESLMQFSKPR 936

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2990	NP_727386.1	Dna2	99..297	CDD:285859
		Cas4_I-A_I-B_I-C_I-D_II-B	<283..415	CDD:294426	9/34 (26%)
		TIGR00376	480..1069	CDD:273041	168/652 (26%)
		P-loop_NTPase	636..859	CDD:304359	75/260 (29%)
		AAA_12	815..1055	CDD:289832	68/254 (27%)
UPF1	XP_016882594.1	DNA2	145..928	CDD:224037	190/780 (24%)
UPF1	XP_016882594.1	DEXXQc_UPF1	489..722	CDD:350797	68/234 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810