Protein Alignment Dna2 and dna2

DIOPT Version :10

• Sequence 1: NP_727386.1
• Gene: Dna2 / 31934
• FlyBaseID: FBgn0288690
• Length: 1100
• Species: Drosophila melanogaster
• Sequence 2: XP_687974.6
• Gene: dna2 / 559535
• ZFINID: ZDB-GENE-090313-71
• Length: 1371
• Species: Danio rerio
• Alignment Length: 1265
• Identity: 385/1265 - (30%)
• Similarity: 589/1265 - (46%)
• Gaps: 282/1265 - (22%)

  Fly    21 SSNPQKKFKEQ----------------------------------LDFSSDEVEN---------I 42
            |.:|:||.|.:                                  |.||:.|.||         .
Zfish   183 SKSPEKKIKTESVSLEGSRLKAGPCLKMNEKLNGFSKDSGRSSHHLSFSTSEKENSPTCNVKSEA 247

  Fly    43 DWG---DNDDFDLAL---------------------IAAMDSISNHRLELTK------------- 70
            |.|   ..:||||.:                     ||....::...|::.:
Zfish   248 DMGAVSGTNDFDLVMSYSSWIQNGSTEEKGTFLNCPIAKKRPLNTSELQVKEQITDGKTLPVPFE 312

  Fly    71 ---------W------QRCEVVRLEQLPN--RKGLKVHVKRISG--------------------- 97
                     |      |:.|..:.::..:  .||:..||...||
Zfish   313 DDFADLMDDWFDEGMEQKSEAPKPKKFSHEKNKGIPEHVVLASGVHNRYWVLDVQDVTSSRSCSE 377

  Fly    98 ---------GDPETADCQLLPPWNCMPMQVGDTVSLLGKWDPSAGCYVVDKEQGYCVSHPDFLIS 153
                     ....|..|.|...|....:.|||.:.|.||.  .:|.:.:|::..:.:..||.|||
Zfish   378 KHLTITCSKTSQATETCILKDGWESTLVTVGDIIHLEGKC--VSGLWTIDRDSAFLILLPDLLIS 440

  Fly   154 GTTVTGSLFCKRKSVLQERFRGLDSGNSVMVIGTLVHELLQKVLRQKLFDKKHIQSALQEMLASS 218
            ||::..|:.|.|:.||.|.|:..|.|:..|:.||:||::.||......|..:.||:...|.|.|.
Zfish   441 GTSIASSIRCMRRGVLGEMFKAFDGGSKQMLNGTIVHDIFQKAAMSSDFSSEKIQTFATEALRSP 505

  Fly   219 SLAHLLYASNLIQVEMEDHLMKFIDPIVSFVAQYVKGEPPSVLLPEVYRGQ-------------- 269
            :....:|:..|.|.:|...:.:::..|..:..||:...|.:        ||
Zfish   506 NYLGQMYSLKLTQADMRQEVEEYLPSISEWAKQYLHTSPQA--------GQKQLTLKLPSDGALS 562

  Fly   270 ---------IHEICDIEENLWVPQLGLKGKVDVSVKVKNQRQ----REEIIPLELKTGRASFSME 321
                     :.:..|||||:|.|:.|||||:||:..||..|:    .|.|:|||||||:.|.|:|
Zfish   563 KQDASSSVMVTDFVDIEENIWCPRFGLKGKIDVTAGVKIHRRGRKPMERIVPLELKTGKESNSIE 627

  Fly   322 HKGQLLLYQLMHSAQGRDTQSGLLLYLKEGLLREVASGRNEQRDLLMLRNDLAYWLTREVAIPAS 386
            |:.|::||.||.||:..|.::|.|:|||.|.|..|.....::|:|:.:||.||:.:...:.
Zfish   628 HRSQVILYTLMSSARRCDPEAGFLVYLKTGSLHPVVGNHMDRRELIKIRNSLAHHIGNNLI---- 688

  Fly   387 KEDPLEQL-PLPEPVYHHSACGNCAYNTICSSF---AQKDSSLQLSDSHPLKKLMPQLL-----E 442
            |.|...|: .||..|.....|..|.....|:.:   .::|...:.|::       ||..     |
Zfish   689 KVDGKSQMAQLPAIVSDQQTCKYCPQKRNCAIYNRAVERDPVEKCSEN-------PQAFVQSESE 746

  Fly   443 HLSEADHAYVQHWCGLLALEEQHNRQSSHVRSFWTKDPAEREKEGIAIRHLKLVKGQEVILEEGR 507
            |||:....|..||..|.:||.....:....|:.|.:...:|||.|....:::|..|.. ||.:|.
Zfish   747 HLSQVHLQYFSHWLLLCSLEALTMEKKGGRRNIWLQTAQQREKIGGCAGNMRLAGGVS-ILSDGV 810

  Fly   508 YRQTLEL--GEEADPSRDLSLSGFDLGEYVVISSTSR--LAVAAGFIVSIEARRLDLRLERDLSQ 568
            |:.:.|.  ||:       :|:|..:|:.:|:|....  :.::.|::..|...|:...|:::||:
Zfish   811 YKHSFERKEGEQ-------TLTGLIVGDRIVVSDQDSVLIGLSTGYVTEIAVNRVTCSLDKNLSK 868

  Fly   569 RYSEETFIIDKHDSQSFATFNFTNLGMLLSEGERFQELRDIIVAKKPPE----QHKVLPKIILTK 629
            ..|...|.:|:.:.....:.:..||.||:......:.||::||..:||:    ...|||:.....
Zfish   869 YSSNTVFRLDQDEGAGGLSTHLGNLSMLMENTPTSERLRELIVEFRPPQFIDSLSSVLPRDAKDI 933

  Fly   630 GAPILLNLNKVQQNAALRALTTSSHLLIKGLPGTGKTQTLVALVRLLHLLGKSVLITAQTHSAVD 694
            .|.||..|||.|:.|..:.|.:..:.||.|:||||||.|:..|||:||..|.|||:|:.||||||
Zfish   934 VANILKGLNKPQKQAMKKVLLSKDYTLIVGMPGTGKTTTICTLVRILHACGFSVLLTSYTHSAVD 998

  Fly   695 NLIMRLLPFGLPMMRLGSGSRIHKQLEEISEERL-TKDCKTVEELEKALGQPSIVGVTCLGCGHP 758
            |::::|..|.:..:|||...::|.::...:||.. .|..:|:||||:...:..||..||:|..||
Zfish   999 NILLKLKRFKIGFLRLGRPQKVHHEILPFTEEACRAKGIQTLEELEQLYSRELIVATTCMGVKHP 1063

  Fly   759 LFQRRQFDYCIVDEATQVLQPTVLRPLIHCSKFVLVGDPEQLPPIVRSKEARQRGADETLFQRLD 823
            :|.||:||:||||||:|:.||..:.||.:..:||||||.:||||||::.|||..|.||:||:||:
Zfish  1064 IFSRRRFDFCIVDEASQISQPVCIGPLFYAQRFVLVGDHQQLPPIVQNAEARSLGMDESLFKRLE 1128

  Fly   824 SEK-ATAVLSLQYRMNKTITRLANELTYGGDLKCASDEVSG----------ARFEVELLNEAPR- 876
            ..: |...|::|||||..|..|:|.|.|.|.|:|.|::.:.          |..|:||....|:
Zfish  1129 HHRDAVVQLNVQYRMNSAIMSLSNALMYEGRLECGSEKTANAVLQLPSRAQAEEELELYVCQPQY 1193

  Fly   877 --WVQRALTTHLEQAVTLINTGDCLERCQEFVYASQRLVDTCSSIEQSFSEDKDEIRKLTSKKRV 939
              |||.||..:  ..|..::|.:               |....::|:
Zfish  1194 SAWVQAALEPN--SPVCFLDTSE---------------VAAPETVEK------------------ 1223

  Fly   940 SKYTNYCEAGIVMHLLRYLLKSGYEASRIGVIAPYRAQVELFKKLASKLDTD----LECNTVDQF 1000
            |..:|:.||.:|..|:..|||:|..|..||||||||.|:   |.::|.|..|    ||.||||::
Zfish  1224 SGISNHTEAVLVQGLVTLLLKAGCRACDIGVIAPYRQQL---KVISSLLQGDAFKALEVNTVDKY 1285

  Fly  1001 QGRDKNLIIYSCSKTGGDFSDMERSREAEILEDQRRLTVAITRAKNKLILLGDIKCLEQYGPFRQ 1065
            |||||::||.|..::..:      ....|:|:|.|||.|||||||:||::||....|.:|.|..:
Zfish  1286 QGRDKSVIIVSFVRSNAE------GNLGELLQDWRRLNVAITRAKHKLLMLGSAPTLRRYAPLEK 1344

  Fly  1066 LFKHIPDRCRLKLEEGRMEFGWQRIQEDLV 1095
            |..|:.                   |||::
Zfish  1345 LLCHLQ-------------------QEDMI 1355

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dna2	NP_727386.1	DNA2_N-like	153..378	CDD:411722	87/251 (35%)
		DEXXQc_DNA2	636..836	CDD:350799	95/201 (47%)
		AAA_12	815..1055	CDD:463780	91/257 (35%)
dna2	XP_687974.6	DNA2_N-like	440..683	CDD:411722	87/250 (35%)
		TIGR00376	785..1351	CDD:273041	225/636 (35%)
		DEXXQc_DNA2	940..1142	CDD:350799	95/201 (47%)