DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG2990 and ZGRF1

DIOPT Version :9

Sequence 1:NP_727386.1 Gene:CG2990 / 31934 FlyBaseID:FBgn0030170 Length:1100 Species:Drosophila melanogaster
Sequence 2:NP_060862.3 Gene:ZGRF1 / 55345 HGNCID:25654 Length:2104 Species:Homo sapiens


Alignment Length:1230 Identity:266/1230 - (21%)
Similarity:436/1230 - (35%) Gaps:400/1230 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 NDNTDVTSSNPQKKFKEQ---LDFS-----------SDEVENIDWGDNDDFDLALIAAMDSISNH 64
            |.||..:|.:|.....|:   |.||           |:|...::.||         .::::||..
Human  1088 NSNTYESSGSPMLNLCEKSAVLSFSIEPEDQNETFFSEESREVNPGD---------VSLNNISTQ 1143

  Fly    65 RLELTKW------QRCEVVRLEQLPNRKGLKVHVKRISGGDPETADCQLLPPWNCMPMQVGDTVS 123
                :||      .:|.|.    .|||..     |||:.|                  ...:.||
Human  1144 ----SKWLKYQNTSQCNVA----TPNRVD-----KRITDG------------------FFAEAVS 1177

  Fly   124 LLGKWDPSAGCYVVDKEQGYCVSHPDFLISGTTVTGSLFCKRKSVLQERFRGLDSGNSVMVIGTL 188
                     |.:..|..:                      ::...:.|  ..|||.:..|:.|.|
Human  1178 ---------GMHFRDTSE----------------------RQSDAVNE--SSLDSVHLQMIKGML 1209

  Fly   189 VHELLQKVLRQKLFDKKHIQSALQEMLASSSLAHLLYASNLIQVEMEDHLMKFIDPIVSFVA-QY 252
            ..:......:..:..||.:...|::...:..:.::|..|......::| |.:.....:.|.: |.
Human  1210 YQQRQDFSSQDSVSRKKVLSLNLKQTSKTEEIKNVLGGSTCYNYSVKD-LQEISGSELCFPSGQK 1273

  Fly   253 VKG---EPPSVLLPEVYRGQIH-----EICDIEENLWVPQLGLK-------GKVDV----SVKVK 298
            :|.   ....:.:|.|::...|     ..|.| |:|.:...||.       .|||:    |:|.:
Human  1274 IKSAYLPQRQIHIPAVFQSPAHYKQTFTSCLI-EHLNILLFGLAQNLQKALSKVDISFYTSLKGE 1337

  Fly   299 NQRQREEIIPLELKTGRASFSMEHKGQLLLYQLMHSAQGRDTQSGLLLYLKEG----------LL 353
            ..:..|..:|          |..|.....|  :|...:|  ...|.|.|..:|          .|
Human  1338 KLKNAENNVP----------SCHHSQPAKL--VMVKKEG--PNKGRLFYTCDGPKADRCKFFKWL 1388

  Fly   354 REVASGRNEQRDLLMLRNDLAYWLTREVAIPASKEDPLEQLPL-----PEPVYHHSACGNCAYNT 413
            .:|..|                :.|:|.|.|......::.:.|     ..|:|..          
Human  1389 EDVTPG----------------YSTQEGARPGMVLSDIKSIGLYLRSQKIPLYEE---------- 1427

  Fly   414 ICSSFAQKDSSLQLSDSHPLKKLMPQLLEHLSE-ADHAYVQHWCGLLALEEQHNRQSSHVRSFWT 477
             |....:|....|......|||......|..:| ....|::     |:.:|:.:..|.:  ..|.
Human  1428 -CQLLVRKGFDFQRKQYGKLKKFTTVNPEFYNEPKTKLYLK-----LSRKERSSAYSKN--DLWV 1484

  Fly   478 KDPAEREKEGIAIRHLKLVKGQEVILEEGRYRQTLELGEEAD----------PSRDLSLSGFDLG 532
                                          ..:||:.  |.|          ||....:....|.
Human  1485 ------------------------------VSKTLDF--ELDTFIACSAFFGPSSINEIEILPLK 1517

  Fly   533 EYVVISSTSRLAVAAGFIVSIEARRLDLRLERD--------LSQ---RYSEETFIIDKHDS-QSF 585
            .|...:..:.:.|.|..:.:.......|:..:|        |:|   ..|..|.:.:|..| :.|
Human  1518 GYFPSNWPTNMVVHALLVCNASTELTTLKNIQDYFNPATLPLTQYLLTTSSPTIVSNKRVSKRKF 1582

  Fly   586 ATFNFTNLGM---LLSEGERFQELRDIIVAKKPPEQHKVLPKIILTKGAPILLNLNKVQQNAALR 647
            ....|||:..   |||.|...:...::|      :.||                |||.|..|.::
Human  1583 IPPAFTNVSTKFELLSLGATLKLASELI------QVHK----------------LNKDQATALIQ 1625

  Fly   648 -ALTTSSH----------------LLIKGLPGTGKTQTL-VALVRLLHLLGKS------------ 682
             |...:||                .:|.|:.|.||:..| |.::..:.|..||            
Human  1626 IAQMMASHESIEEVKELQTHTFPITIIHGVFGAGKSYLLAVVILFFVQLFEKSEAPTIGNARPWK 1690

  Fly   683 VLITAQTHSAVDNLIMRLLPFGLP-MMRLGSGSRI---------H----------KQLEEISEER 727
            :||::.|:.|||.:::.||..|.. .:|:||..:|         |          |:|..:.:|.
Human  1691 LLISSSTNVAVDRVLLGLLSLGFENFIRVGSVRKIAKPILPYSLHAGSENESEQLKELHALMKED 1755

  Fly   728 LTKD-----CKTVEELE-----KALGQPSIVGVTCLGCGHPLFQRRQFDYCIVDEATQVLQPTVL 782
            ||..     .|::|:.:     ..|.|..:|||||..|..|.....:|...::||.:|:.:|..|
Human  1756 LTPTERVYVRKSIEQHKLGTNRTLLKQVRVVGVTCAACPFPCMNDLKFPVVVLDECSQITEPASL 1820

  Fly   783 RPL--IHCSKFVLVGDPEQLPPIVR-SKEARQRGADETLFQRLD-SEKATAVLSLQYRMNKTITR 843
            .|:  ..|.|.:|||||:||||.:: |..|.:.|.::|||.||. ......:|..|||.:..|:.
Human  1821 LPIARFECEKLILVGDPKQLPPTIQGSDAAHENGLEQTLFDRLCLMGHKPILLRTQYRCHPAISA 1885

  Fly   844 LANELTYGGDLKCASDEVSGARFEVELLNEAPRWVQRALTTHLEQAVTLINTGDCLERCQEFVYA 908
            :||:|.|.|                .|:|                .||.|.....||......:.
Human  1886 IANDLFYKG----------------ALMN----------------GVTEIERSPLLEWLPTLCFY 1918

  Fly   909 SQRLVDTCSSIEQSFSEDKDEIRKLTSKKRVSKYTNYCEAGIVMHLLRYLLKSGYEASRIGVIAP 973
            :                    ::.|...:|.:.:.|..||...:.|::.|:.||...|.||||..
Human  1919 N--------------------VKGLEQIERDNSFHNVAEATFTLKLIQSLIASGIAGSMIGVITL 1963

  Fly   974 YRAQVELFKKLASKLD------TDLECNTVDQFQGRDKNLIIYSCSKTGGDFSDMERSREAEILE 1032
            |::|:.....|.|.:|      ..::.:|||.|||.:|.:||.||.:|          |:...::
Human  1964 YKSQMYKLCHLLSAVDFHHPDIKTVQVSTVDAFQGAEKEIIILSCVRT----------RQVGFID 2018

  Fly  1033 DQRRLTVAITRAKNKLILLGDIKCLEQYGPFRQLFKHIPDRCRLKLEEGRMEFGWQRIQE 1092
            .::|:.||:||.|..|:::|::.||.:    .||:..:...|     ||| |.|.|...:
Human  2019 SEKRMNVALTRGKRHLLIVGNLACLRK----NQLWGRVIQHC-----EGR-EDGLQHANQ 2068

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG2990NP_727386.1 Dna2 99..297 CDD:285859 34/217 (16%)
Cas4_I-A_I-B_I-C_I-D_II-B <283..415 CDD:294426 28/157 (18%)
TIGR00376 480..1069 CDD:273041 164/683 (24%)
P-loop_NTPase 636..859 CDD:304359 84/286 (29%)
AAA_12 815..1055 CDD:289832 62/246 (25%)
ZGRF1NP_060862.3 AAA_11 1614..1844 CDD:289831 67/245 (27%)
DNA2 <1739..2057 CDD:224037 104/388 (27%)
AAA_12 1855..2039 CDD:289832 61/245 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2085..2104
DUF2439 4..73 CDD:287368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 335..359
zf-GRF 1347..1391 CDD:284302 11/57 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1112
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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