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Protein Alignment Dna2 and Helz

DIOPT Version :10

Sequence 1:	NP_727386.1	Gene:	Dna2 / 31934	FlyBaseID:	FBgn0288690	Length:	1100	Species:	Drosophila melanogaster
Sequence 2:	NP_648725.2	Gene:	Helz / 39613	FlyBaseID:	FBgn0036451	Length:	2103	Species:	Drosophila melanogaster

Alignment Length:	959	Identity:	188/959 - (19%)
Similarity:	316/959 - (32%)	Gaps:	330/959 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   377 LTREVAIPASKEDPLEQLPLPEPVYHHSACGNCAYNTICSSFAQKDSSLQLSDSHPLKKLMPQLL 441
            |.|.:...|.:....|::|..|     :.|......:|.|..::::...||....|||.:  .||
  Fly   388 LDRWIQATAPERVMCERVPDME-----ARCEQQLVTSISSKTSKREWLFQLETKKPLKAV--ALL 445

  Fly   442 EHLSEADHAYVQHWCGLLALEE----QHNRQSSHVRS--FW-----TKDPAEREKEGIAIRHLKL 495
            :      .|:..|:    ||:.    :....|..::|  .|     ::.....|.....|..:.:
  Fly   446 Q------DAHRNHF----ALKSIKMCKPTESSMELKSDQEWLAGSSSQSETSNEDSATLIHEITV 500

  Fly   496 VKGQEVILEEGRYRQTL--ELGEEADPSRDLSLSGFDLGEY---------VVISSTSRLAVA--- 546
            ....|:.   |.:||.:  ::|:|....|.|.:....:.:.         ::.||.:|..||
  Fly   501 EFHTEIY---GTFRQAICFDVGQEPLLVRHLCVDVLPVNDAEKIEEIKRDIINSSATRWDVANTQ 562

  Fly   547 -------AGFIVSIEARRLDLRLERDLSQRYS---------EETFIIDKHDSQS----------- 584
                   .|..:..||...||..||:|.:||.         .::.|::|..:|:
  Fly   563 LTRFETTIGTHLKTEAYLSDLEHERELLERYPCPRAATFTLTQSTIVEKRLTQNNYRSRIHELLS 627

  Fly   585 ---------FATFN------------FTNLGMLLS------EGERFQELR---DI---------- 609
                     .|.:|            .|..||..|      .||.|..:|   ||
  Fly   628 VEEIARYEQIARYNVRTRLTVASNYILTPAGMATSTAKYSLAGELFALMRLGKDISEDTSPGRLI 692

  Fly   610 ------IVAKKP--------PEQHKVLPKIILTKGAPIL-------------------------L 635
                  :...||        |.:..|...:|..||..::                         .
  Fly   693 LSNCSSVYISKPEDPDSKADPTKRAVYEALIEDKGKNVIYLKLSAKCVEAMALQADTELEVDIQF 757

  Fly   636 NLNKV----------------------------------------------QQNAALRALTTS-- 652
            .||::                                              :|..|:.|:||:
  Fly   758 QLNRMPYCEWHNAVDKITDFRLIFPATELEPSIPWTPKKQWADSCEPKLNAKQREAVNAITTALS 822

  Fly   653 ---SHLLIKGLPGTGKTQTLV-ALVRLLHLLGKSVLITAQTHSAVDNLIMRLL-PFGLPMMRLGS 712
               ..:|:.|..|||||.||. |:.:||......:||...::||.|..|...| |:....::..:
  Fly   823 IKLPPILLIGPFGTGKTYTLAQAIKQLLTQPEAKILICTHSNSAADLYIKEYLHPWIEEGLKEAT 887

  Fly   713 GSRI--HKQLEEISEERLTKDC----------KTVEELEKALGQPSIVGVT--------CLGCGH 757
            ..|:  ||:........:.|.|          .|||::.:    ..||.||        .||...
  Fly   888 PLRVYYHKRWSATVNGVVQKYCITDGVGNFLRPTVEDIMR----HRIVVVTLSISMELATLGLPK 948

  Fly   758 PLFQRRQFDYCIVDEATQVLQPTVLRPLI---HCSKFVLVGDPEQLPPIVRSKEARQRGADETLF 819
            .|     |.:..:|||.|.::...:.||.   ..::.||.||..|:.|.:.|..|::|....:|.
  Fly   949 GL-----FTHIFLDEAAQAMECEAIMPLALANDSTRIVLAGDHMQMSPELFSAFAKERKLHISLL 1008

  Fly   820 QRL-----DSEKATAVLSLQYRMNKTITRLANELTYGGDLKCASDEVSGARFEVELLNEAPRWVQ 879
            :||     .:.....:|...||.::.|.|..:||.|...|..:..:....||
  Fly  1009 ERLYDHYPSNFPCKILLCENYRAHEAIIRFTSELFYEQKLVASGKQPRHDRF------------- 1060

  Fly   880 RALTTHLEQAVTLINTGDCLERCQEFVYASQRLVDTCSSIEQSFSEDKDEIRKLTSKKRVSKYTN 944
                    ..:|...|.                           .||..:       |..:.:.|
  Fly  1061 --------YPLTFFTTR---------------------------GEDVQD-------KNSTAFYN 1083

  Fly   945 YCEAGIVMHLLRYLLKSGYEA------SRIGVIAPYRAQV-----ELFKKLASKLDTDLECNTVD 998
            ..|...|:..:..|.|....|      :.||::.||..||     ||.|:....:..:...|.
  Fly  1084 NAEVYEVVERVSELRKRWPSAWGKLNDTSIGIMTPYSDQVFRIRSELRKRRMGGISVERVLNV-- 1146

  Fly   999 QFQGRDKNLIIYSCSKT-----------GGDFSDMERSREAE--ILEDQRRLTVAITRAKNKLIL 1050
              ||:....:..|..:|           |...:......:|:  .|.:.:.|..|||||::.:.:
  Fly  1147 --QGKQFRAVFLSTVRTRRTCMPQGSAPGSASTTSIGDADADYGFLSNSKLLNTAITRAQSLVAV 1209

  Fly  1051 LGDIKCLEQYGPFRQLFKHIPDRCRLKLEEGRMEFG--WQRIQEDLVGL 1097
            :||...|...|..|::::...:.|    :|.:..||  |..::..|.|:
  Fly  1210 VGDPVALCSIGRCRKVWERFIEIC----DEHKSLFGLTWSNLRSQLDGV 1254

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.