Protein Alignment Dna2 and Setx

DIOPT Version :10

• Sequence 1: NP_727386.1
• Gene: Dna2 / 31934
• FlyBaseID: FBgn0288690
• Length: 1100
• Species: Drosophila melanogaster
• Sequence 2: NP_001137907.1
• Gene: Setx / 38904
• FlyBaseID: FBgn0035842
• Length: 1676
• Species: Drosophila melanogaster
• Alignment Length: 1380
• Identity: 275/1380 - (19%)
• Similarity: 466/1380 - (33%)
• Gaps: 479/1380 - (34%)

  Fly    12 LENDNTDVTSSNPQKKFKEQLDFSSDEVENIDWGDNDDFDLALIAAMDSISNHRLELTKWQRCEV 76
            :||.....:.||.|   :||:..|.:|..||              ....|..::....|
  Fly   469 MENMTETKSCSNRQ---REQIVASRNEPTNI--------------CPQKIETNKTSTRK------ 510

  Fly    77 VRLEQLPNRKGLKVHVKRISGGDPETADCQLLPPWNCMPMQVGDTVSLLGKWDPSAGCYVVDKEQ 141
             |.....:|..|....|.|........:    ||...:..:             |..||
  Fly   511 -RFVSTTSRDELSTTSKEIKDAPKNNVE----PPKKMLRSR-------------SKSCY------ 551

  Fly   142 GYCVSHPDFLISGTTVTGSLFCKRKSVLQERFRGLDSGNSVMVIGTLVHELLQKVLRQK------ 200
               :..|..|....|       |.:..|::::..:|:....:::......:|....:.|
  Fly   552 ---IDRPVELDEHIT-------KNEVPLKKKYESVDNSKEELIVTLEAPAMLTTPTKSKTQCVKK 606

  Fly   201 -----------LFDKKHIQSALQEMLASSSL---------------------AHLL------YAS 227
                       :..:..|:|...|...:..:                     |.||      |..
  Fly   607 KATQTRGRRKTIHSRDEIRSLTAEAEENKKISPAKQTNEEIPIPTKSPLKRNARLLNRSKSCYMD 671

  Fly   228 NLIQVEMEDHLMKFI-----------DPIVSFV-AQYVKGEPPSVL----LPEVYRGQIHEICDI 276
            .|:..|.||...|.|           |.:::|| .:..:|  |||:    ||: .||:
  Fly   672 RLVISETEDPAKKVIKDISPTKSDTTDNVLNFVDVRQTRG--PSVIEAPSLPK-NRGK------- 726

  Fly   277 EENLWVPQLGLKGKVDVSVKVKNQ-RQREEIIPLELKTGRASFSMEHKGQLLLYQLMHSAQGRDT 340
                      |:| |...||||:: ..|:..|..:.:. .|.:..:.|.:....:.:...: |:.
  Fly   727 ----------LRG-VSAEVKVKDKVLDRQRFIDYQAEM-NAKWKQKPKDKKKEDEKLKECR-REA 778

  Fly   341 QSGLLLYLKEGLLREVASGRNEQRDLLMLRN-DLAYWLTREVAIPA--------SKEDPLEQLPL 396
            ...|....||...|...:.|.....:..::| :...:||:.|..||        :|..|.:.:|.
  Fly   779 LKKLSEKPKENSHRSTTNKRKNPTSVPTVQNTNRGGFLTKGVDGPAPKLAKTDNAKPPPKKPVPK 843

  Fly   397 PEPVYHHSACGNCAYNTICSSFAQKDSSLQLSDS---HPLKKLMPQLLEHL--SEADHAYVQHWC 456
            ..|.              ..:|:|:   ||.:|.   ||    .||....:  .||:.|..|..|
  Fly   844 QPPA--------------IETFSQQ---LQAADKAVLHP----QPQCSRPVERKEAELARNQRTC 887

  Fly   457 GLLALEEQ--HNRQSSHVRSFWTKDPAEREKEGIAIRHLKLVKG--------QEVI-LEEGRYRQ 510
            ..:...|.  :::::...:....|.......:.:.:..::.|||        :|.| |....||:
  Fly   888 NKVTFAEMELYHQKAEDSKKLQKKLRKVHFNDDVKVHCIERVKGASSKVQGRKECIKLRLSSYRE 952

  Fly   511 TLE-LGEEADPSRDLSLSGFDL----GEYVVISSTSRLAVAAGFI----------------VSIE 554
            ..| :..|..|..|:......:    .:::...|..  |||...:                :.:.
  Fly   953 RREWIRRENKPVNDIRQHSRSILKWANQWLKHGSVD--AVAEQDVLMPIPPEFDSFKNYREIFVP 1015

  Fly   555 ARRLDL--RLERDLSQRYSEETF---------------IIDKHDSQSFATFNFTNL---GMLLSE 599
            ..:|:|  .:|||.... ::.||               ::.:.:|:.|..|....|   |||...
  Fly  1016 LMKLELLSTIERDYKIN-NKNTFSVSLINVETQDMCYRLVTRVNSKPFGKFVLYTLYCCGMLKET 1079

  Fly   600 GERFQELRDII---------VAKKPPEQHKV---------------------------------- 621
            .....||:.:.         :.|:...:.|:
  Fly  1080 FANLLELKFVSGNVFDLTFEILKQDISEEKLKNIKQLTARPVVDSLRVELGALSAVHQLRSSPLC 1144

  Fly   622 --------------LPKIILT-KGAPILLNLNKVQQNAALRAL------TTSSHLLIKGLPGTGK 665
                          |||...| ||..   .||:.|:|..|...      ...|..||:|.|||||
  Fly  1145 RRILKPTQTVNEVSLPKQPFTFKGCH---KLNEHQENIVLHTYQRIIDDLQPSLTLIQGPPGTGK 1206

  Fly   666 TQTLVAL-VRLLH-----LLGKSVLITAQTHSAVDNLI--------------MRLLPFGL----- 705
            ::.:..| ::.|:     .|.:.:||.|.:::|||:::              ..||.||:
  Fly  1207 SRVISELCLQTLYGNAAKTLDRKILICAHSNTAVDHIVGLLGSVLRVMNRDQFHLLRFGMHEKMS 1271

  Fly   706 ----PMMRLGSGSRIHKQ-LEEISEER---LTK---DCKTVEELEKALGQPSIVGVTCL------ 753
                |.......::..:| |:.:|:|.   |.|   |.|  :|:::...:.::.....|
  Fly  1272 HYSRPFSLEAHFNKAKEQKLQRVSKENAEILKKQHNDLK--DEIQQLKEKTNLTSTYLLQQLQQK 1334

  Fly   754 ---------GCGHPLFQRRQ------------------------------FDYCIVDEATQVLQP 779
                     ....||.||.:                              ||.||||||||..:|
  Fly  1335 EKKLQLISNQLSPPLTQREEFEISHMCVTRANIICTTLSSCVKLANYVDFFDICIVDEATQCTEP 1399

  Fly   780 TVLRPL-IHCSKFVLVGDPEQLPPIVRSKEARQRGADETLFQRLDSEKATAV------------- 830
            ..|.|: ...:..|||||.:|||.:|.||:|...|...::|.|:.....|.:
  Fly  1400 WTLLPMRFGLTHMVLVGDMQQLPAVVLSKKAIDFGLSNSMFDRIQRSLQTQLDKPGSYHLMHTKL 1464

  Fly   831 --LSLQYRMNKTITRLANELTYGGDLKCASDEVSGARFEVELLNEAPRWVQRALTTHLEQAVTLI 893
              ||.||||:..|.|..|:..|                |.:|:|
  Fly  1465 FKLSTQYRMHPEICRWPNQYFY----------------EDQLIN--------------------- 1492

  Fly   894 NTGDCLERCQEFVYASQRLVDTCSSIEQSFSEDKDEIRKLTSKKRVSKYTNYCEAGIVMHLLRYL 958
              .:|..|     :||. |:..| .|...::.|.:.    ...|.:|   |..||..|..||..:
  Fly  1493 --AECTAR-----FASP-LIPYC-VINLKYTCDSNG----AQNKSIS---NNEEARFVAKLLTEM 1541

  Fly   959 LKSGYEASR---IGVIAPYRAQ-VELFKKLASKLDTDLECNTVDQFQGRDKNLIIYSCSKTGGDF 1019
            .|  :..|:   .|:|:||:.| ..|.:.:.|.:  ::...|||.:||.:|::||.|.::|.|
  Fly  1542 DK--HMPSKRFSYGLISPYQNQCYALSQVIPSHM--NITPQTVDSYQGLEKDVIIISNARTRG-- 1600

  Fly  1020 SDMERSREAEILEDQRRLTVAITRAKNKLILLGDIKCLEQYGPFRQLFKHIPDRCRLKLEEGRME 1084
                    ...|.:.:||.||:||.:..|::.|:.:.|:....:|.|           |::.|..
  Fly  1601 --------CGFLTNYQRLNVALTRPRRCLVICGNFEDLKSVEMWRNL-----------LDDARKR 1646

  Fly  1085 FGWQRIQEDLVGLMD 1099
            ..:..:..|.|..:|
  Fly  1647 KVYFNLDRDDVNDLD 1661

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dna2	NP_727386.1	DNA2_N-like	153..378	CDD:411722	48/286 (17%)
		DEXXQc_DNA2	636..836	CDD:350799	74/302 (25%)
		AAA_12	815..1055	CDD:463780	61/258 (24%)
Setx	NP_001137907.1	FHA	12..94	CDD:438714
		AAA_11	1175..1428	CDD:404072	62/254 (24%)
		DNA2	<1299..1646	CDD:440729	102/426 (24%)