DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG2990 and IGHMBP2

DIOPT Version :9

Sequence 1:NP_727386.1 Gene:CG2990 / 31934 FlyBaseID:FBgn0030170 Length:1100 Species:Drosophila melanogaster
Sequence 2:NP_002171.2 Gene:IGHMBP2 / 3508 HGNCID:5542 Length:993 Species:Homo sapiens


Alignment Length:732 Identity:184/732 - (25%)
Similarity:289/732 - (39%) Gaps:193/732 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   445 SEADHAYVQHWCGLLALE---EQHNRQSSHVRSFWTKDPAEREKEGIAIRHLKL-VKGQE----- 500
            |.|..::|.....||.||   |...|:|      |.::.:.:|.:...:..||| |..|.     
Human     3 SAAVESFVTKQLDLLELERDAEVEERRS------WQENISLKELQSRGVCLLKLQVSSQRTGLYG 61

  Fly   501 ---VILEEGRYRQTLELGEEADPSRDLSLSGFDLGEYVVISSTSRLAVAAGFIVSI--------- 553
               |..|..||.....|     ||...: ||..:|.|...:..|:|  |.|.:..:         
Human    62 RLLVTFEPRRYGSAAAL-----PSNSFT-SGDIVGLYDAANEGSQL--ATGILTRVTQKSVTVAF 118

  Fly   554 -EARRLDLRLERDLSQRYSEETFIIDKHDSQSFATFNFTNLGMLLSEGERFQELRDIIVAKKPPE 617
             |:....|.|:|:.|.|.                        :.|:....::.|:..::|.|  :
Human   119 DESHDFQLSLDRENSYRL------------------------LKLANDVTYRRLKKALIALK--K 157

  Fly   618 QH----KVLPKIILTKGAP---------ILLN--LNKVQQNAALRALTTSSHLLIKGLPGTGKTQ 667
            .|    ..|.:::..:.||         ...|  |:..|:.|.|.||:.....:|.|.||||||.
Human   158 YHSGPASSLIEVLFGRSAPSPASEIHPLTFFNTCLDTSQKEAVLFALSQKELAIIHGPPGTGKTT 222

  Fly   668 TLVALVRLLHLLGKSVLITAQTHSAVDNLIMRLLPFGLPMMRLGSGSRIHKQLEEIS-------- 724
            |:|.::......|..||..|.::.|||||:.||......::|||..:|:.:.:::.|        
Human   223 TVVEIILQAVKQGLKVLCCAPSNIAVDNLVERLALCKQRILRLGHPARLLESIQQHSLDAVLARS 287

  Fly   725 -------------EERLTKDCKTVEELEK------------------------ALGQPSIVGVTC 752
                         ::...|:.||.::.||                        :|...::|..|.
Human   288 DSAQIVADIRKDIDQVFVKNKKTQDKREKSNFRNEIKLLRKELKEREEAAMLESLTSANVVLATN 352

  Fly   753 LGCGH----PLFQRRQFDYCIVDEATQVLQPTVLRPLIHCSKFVLVGDPEQLPPIVRSKEARQRG 813
            .|...    .|.....||..::||..|.|:.:...||:...|.:|.||.:||||...|.:|...|
Human   353 TGASADGPLKLLPESYFDVVVIDECAQALEASCWIPLLKARKCILAGDHKQLPPTTVSHKAALAG 417

  Fly   814 ADETLFQRLDSE---KATAVLSLQYRMNKTITRLANELTYGGDLKCASDEVSGARFEVELLNEAP 875
            ...:|.:||..|   :....|::||||::.|.|.|::..|.|.|...|   |.||   .||.:.|
Human   418 LSLSLMERLAEEYGARVVRTLTVQYRMHQAIMRWASDTMYLGQLTAHS---SVAR---HLLRDLP 476

  Fly   876 RWVQRALTTHLEQAVTLINTGDCLERCQEFVYASQRLVDT--CSSIEQSFSEDKDEIRKLTSKKR 938
                 .:....|..|.|:                  ||||  |...|   .|::||..|      
Human   477 -----GVAATEETGVPLL------------------LVDTAGCGLFE---LEEEDEQSK------ 509

  Fly   939 VSKYTNYCEAGIVMHLLRYLLKSGYEASRIGVIAPYRAQVELFKKLASKLDTDLECNTVDQFQGR 1003
                .|..|..:|...::.|:.:|..|..|.|::||..||:|.::.......:||..:||.||||
Human   510 ----GNPGEVRLVSLHIQALVDAGVPARDIAVVSPYNLQVDLLRQSLVHRHPELEIKSVDGFQGR 570

  Fly  1004 DKNLIIYSCSKTGGDFSDMERSREAEILEDQRRLTVAITRAKNKLILLGD-------------IK 1055
            :|..:|.|       |....|..|...|.:.||:.||:|||:..:.::.|             ::
Human   571 EKEAVILS-------FVRSNRKGEVGFLAEDRRINVAVTRARRHVAVICDSRTVNNHAFLKTLVE 628

  Fly  1056 CLEQYGPFRQLFKHIPD 1072
            ...|:|..|..|:::.|
Human   629 YFTQHGEVRTAFEYLDD 645

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG2990NP_727386.1 Dna2 99..297 CDD:285859
Cas4_I-A_I-B_I-C_I-D_II-B <283..415 CDD:294426
TIGR00376 480..1069 CDD:273041 172/689 (25%)
P-loop_NTPase 636..859 CDD:304359 77/276 (28%)
AAA_12 815..1055 CDD:289832 71/257 (28%)
IGHMBP2NP_002171.2 TIGR00376 19..641 CDD:273041 177/710 (25%)
AAA_19 198..256 CDD:289986 24/57 (42%)
AAA_12 418..615 CDD:289832 71/245 (29%)
SS DNA-binding. /evidence=ECO:0000250 638..785 2/8 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 651..723
R3H_Smubp-2_like 726..784 CDD:100070
DUF3628 <766..850 CDD:289100
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 782..828
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 841..879
Nuclear localization signal. /evidence=ECO:0000255 864..868
zf-AN1 897..934 CDD:279736
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 971..993
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1112
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D289214at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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