DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG2990 and Dna2

DIOPT Version :9

Sequence 1:NP_727386.1 Gene:CG2990 / 31934 FlyBaseID:FBgn0030170 Length:1100 Species:Drosophila melanogaster
Sequence 2:NP_796346.2 Gene:Dna2 / 327762 MGIID:2443732 Length:1062 Species:Mus musculus


Alignment Length:1098 Identity:352/1098 - (32%)
Similarity:562/1098 - (51%) Gaps:142/1098 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    48 DDFDLALI---AAMDSISNHRLELTKWQ----------------RCEVVRLEQLPNRKGL---KV 90
            |:.||.|:   ...:::.  |:||.:.:                |..|:.:|...|.:|.   ::
Mouse     5 DELDLLLLEEDGGAEAVP--RVELLRKKADALFPETVLSRGVDNRYLVLAVETSQNERGAEEKRL 67

  Fly    91 HVKRISGGDPETADCQLLPPWNCMPMQVGDTVSLLGKWDPSAGCYVVDKEQGYCVSHPDFLISGT 155
            ||......:.|.. |.|...|:.:|::.||.|.|.|  |.::..:::|.:.||.:.:||.:||||
Mouse    68 HVTASQDREHEVL-CILRNGWSSVPVEPGDIVHLEG--DCTSEPWIIDDDFGYFILYPDMMISGT 129

  Fly   156 TVTGSLFCKRKSVLQERFRGLDSGNSVMVIGTLVHELLQKVLRQKLFDKKHIQSALQEMLASSSL 220
            :|..|:.|.|::||.|.|||.|.....|:|||::||:.||.:.:....::..:.|||.:   ..:
Mouse   130 SVASSIRCLRRAVLSETFRGSDPATRQMLIGTILHEVFQKAISESFAPERLQELALQTL---REV 191

  Fly   221 AHL--LYASNLIQ----VEMEDHLMKFIDPIVSFVAQYVKGEPPSVLLPEVYRG---------QI 270
            .||  :|..||.|    .|:|::|..|......|:.:....|.|.:.|.....|         ::
Mouse   192 RHLKEMYRLNLSQDEILCEVEEYLPSFSKWAEDFMRKGPSSEFPQMQLSLPSDGSNRSSPCNIEV 256

  Fly   271 HEICDIEENLWVPQLGLKGKVDVSVKVKNQR---QREEIIPLELKTGRASFSMEHKGQLLLYQLM 332
            .:..||||::|.|:.|||||:||:|.||..|   .:.:::|||||||:.|.|:||:.|::||.|:
Mouse   257 VKSLDIEESIWSPRFGLKGKIDVTVGVKIHRDCKMKYKVMPLELKTGKESNSIEHRSQVVLYTLL 321

  Fly   333 HSAQGRDTQSGLLLYLKEGLLREVASGRNEQRDLLMLRNDLAYWLTREVAIPASKEDPLEQL--- 394
            ...:..|.::|.|||||.|.:..|.:...::|:||.|||    ||...:....|:..|.|:.   
Mouse   322 SQERREDPEAGWLLYLKTGQMYPVPANHLDKRELLKLRN----WLAASLLHRVSRAAPGEEARLS 382

  Fly   395 PLPEPVYHHSAC------GNCAYNTICSSFAQKDSSLQLSDSHPLKKLMPQLLEHLSEADHAYVQ 453
            .||:.:.....|      ||||..:........|:|:   ....|.|:..: ..||..|...|..
Mouse   383 ALPQIIEEEKTCKYCSQIGNCALYSRAVEEQGDDASI---PEAMLSKIQEE-TRHLQLAHLKYFS 443

  Fly   454 HWCGLLALEEQHNRQSSHVRSFWTKDPAEREKEGIAIRHLKLVKGQEVI-LEEGRYRQTLELGEE 517
            .||.:|.||.|........:|.|....:|.|:.|..:.:  ||:.:.|. :.:|:|....:....
Mouse   444 LWCLMLTLESQSKDNRKTHQSIWLTPASELEESGNCVGN--LVRTEPVSRVCDGQYLHNFQRKNG 506

  Fly   518 ADPSRDLSLSGFDLGEYVVISSTSR--LAVAAGFIVSIEARRLDLRLERDLSQRYSEETFIIDKH 580
            ..|:.:|.     .|:.:::|...|  .|::.|::..:....:...|:|:||...:...|.:|:.
Mouse   507 PMPATNLM-----AGDRIILSGEERKLFALSKGYVKKMNKAAVTCLLDRNLSTLPATTVFRLDRE 566

  Fly   581 DSQSFATFNFTNLGMLLSEGERFQELRDIIVAKKPPE----QHKVLPKIILTKGAPILLNLNKVQ 641
            :.....:....||..|:...:..:.||::|:..:.|:    ...|||.......|.||..|||.|
Mouse   567 ERHGDISTPLGNLSKLMESTDPSKRLRELIIDFREPQFIAYLSSVLPHDAKDTVANILKGLNKPQ 631

  Fly   642 QNAALRALTTSSHLLIKGLPGTGKTQTLVALVRLLHLLGKSVLITAQTHSAVDNLIMRLLPFGLP 706
            :.|..|.|.:..:.||.|:||||||.|:.||||:|...|.|||:|:.|||||||::::|..|.:.
Mouse   632 RQAMKRVLLSKDYTLIVGMPGTGKTTTICALVRILSACGFSVLLTSYTHSAVDNILLKLAKFKVG 696

  Fly   707 MMRLGSGSRIHKQLEEISEERL--TKDCKTVEELEKALGQPSIVGVTCLGCGHPLFQRRQFDYCI 769
            .:|||...::|..:::.:||.:  ::...::..||:......||..||:|..||:|.|:.||:||
Mouse   697 FLRLGQSHKVHPDIQKFTEEEICRSRSIASLAHLEELYNSHPIVATTCMGINHPIFSRKTFDFCI 761

  Fly   770 VDEATQVLQPTVLRPLIHCSKFVLVGDPEQLPPIVRSKEARQRGADETLFQRLD-SEKATAVLSL 833
            ||||:|:.||..|.||....:||||||.:||||:|.::|||..|..|:||:||: :|.|...|::
Mouse   762 VDEASQISQPVCLGPLFFSRRFVLVGDHQQLPPLVVNREARALGMSESLFKRLERNESAVVQLTV 826

  Fly   834 QYRMNKTITRLANELTYGGDLKCASDEVSG----------ARFEVEL---LNEAPRWVQRALTTH 885
            |||||:.|..|:|:|||.|.|:|.||.|:.          ||..::|   .:::| |:...|.. 
Mouse   827 QYRMNRKIMSLSNKLTYAGKLECGSDRVANAVLALPNLKDARLSLQLYADYSDSP-WLAGVLEP- 889

  Fly   886 LEQAVTLINTGDCLERCQEFVYASQRLVDTCSSIEQSFSEDKDEIRKLTSKKRVSK--YTNYCEA 948
             :..|..:||.                                   |:.:.::|..  .:|..||
Mouse   890 -DNPVCFLNTD-----------------------------------KVPAPEQVENGGVSNVTEA 918

  Fly   949 GIVMHLLRYLLKSGYEASRIGVIAPYRAQVELFKKLASKLDTDL-ECNTVDQFQGRDKNLIIYSC 1012
            .:::.|....:|:|...|.||||||||.|:.:...|.::....: |.||||::|||||:||:.|.
Mouse   919 RLIVFLTSTFIKAGCSPSDIGVIAPYRQQLRIISDLLARSSVGMVEVNTVDKYQGRDKSLILVSF 983

  Fly  1013 SKTGGDFSDMERSREAEILEDQRRLTVAITRAKNKLILLGDIKCLEQYGPFRQLFKHI 1070
            .::..|      ....|:|:|.|||.||:||||:||||||.:..|:::.|...||.|:
Mouse   984 VRSNED------GTLGELLKDWRRLNVALTRAKHKLILLGSVSSLKRFPPLGTLFDHL 1035

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG2990NP_727386.1 Dna2 99..297 CDD:285859 71/212 (33%)
Cas4_I-A_I-B_I-C_I-D_II-B <283..415 CDD:294426 54/143 (38%)
TIGR00376 480..1069 CDD:273041 205/614 (33%)
P-loop_NTPase 636..859 CDD:304359 104/225 (46%)
AAA_12 815..1055 CDD:289832 85/256 (33%)
Dna2NP_796346.2 Dna2 72..283 CDD:285859 71/216 (33%)
Nuclease activity. /evidence=ECO:0000250 82..520 141/457 (31%)
Cas4_I-A_I-B_I-C_I-D_II-B <256..398 CDD:294426 55/145 (38%)
TIGR00376 472..1034 CDD:273041 205/612 (33%)
Helicase activity. /evidence=ECO:0000250 521..1062 195/559 (35%)
P-loop_NTPase 626..830 CDD:304359 92/203 (45%)
AAA_12 806..1020 CDD:289832 85/257 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 115 1.000 Domainoid score I6022
eggNOG 1 0.900 - - E1_COG1112
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H6124
Inparanoid 1 1.050 502 1.000 Inparanoid score I1344
Isobase 1 0.950 - 0 Normalized mean entropy S2517
OMA 1 1.010 - - QHG56923
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002978
OrthoInspector 1 1.000 - - oto92180
orthoMCL 1 0.900 - - OOG6_102643
Panther 1 1.100 - - LDO PTHR10887
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R324
SonicParanoid 1 1.000 - - X1978
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1514.810

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