Protein Alignment Dna2 and Upf1

DIOPT Version :10

• Sequence 1: NP_727386.1
• Gene: Dna2 / 31934
• FlyBaseID: FBgn0288690
• Length: 1100
• Species: Drosophila melanogaster
• Sequence 2: NP_572767.1
• Gene: Upf1 / 32153
• FlyBaseID: FBgn0030354
• Length: 1180
• Species: Drosophila melanogaster
• Alignment Length: 844
• Identity: 204/844 - (24%)
• Similarity: 349/844 - (41%)
• Gaps: 237/844 - (28%)

  Fly   352 LLREVASGRNEQRDL---------LMLRNDLAYWLTREVA---------IPASKEDPLEQLPLPE 398
            |.|:..:.:|..:|:         |:.......||.::.:         |.|::.:.||:|
  Fly   185 LCRQPCAAQNSLKDMNWDQEQWKPLIADRCFLAWLVKQPSEQGQLRARQISAAQINKLEEL---- 245

  Fly   399 PVYHHSACGNCAYNTICSSFAQKDSSLQLSDSHPLKKLMPQLLEHLSEADHAYVQHWCGLLALEE 463
                       ....|.::|  :|......||.|...|:..      |..:.|.:.:..|:.||.
  Fly   246 -----------WKENIEATF--QDLEKPGIDSEPAHVLLRY------EDGYQYEKTFGPLVRLEA 291

  Fly   464 QHNRQSSHVRSFWTKDPAERE-----------KEGIAI-------RHLKLVKGQEVILEEGRYRQ 510
            :::::        .|:.|.:|           |:.||.       ..:||:.|.|:.|.
  Fly   292 EYDQK--------LKESATQENIEVRWDVGLNKKTIAYFTLAKTDSDMKLMHGDELRLH------ 342

  Fly   511 TLELGEEADPSRDL-------SLSGFDLGEYVVISSTSRLAVAAGFIVSI--EARRLDLRLERDL 566
              .:||..:|..::       ...|.|:|..:..|:.:.:...:.|.|..  :....| |:.|.|
  Fly   343 --YVGELYNPWSEIGHVIKVPDNFGDDVGLELKSSTNAPVKCTSNFTVDFIWKCTSFD-RMTRAL 404

  Fly   567 SQRYSEETFIIDKHDSQSFATFNFTNLGMLLSEGERFQELRDIIVAKKPPEQHKVLPKIILTKGA 631
            .:      |.||::...:|.      ...||..|.  .:..|.::.:.|.      ||:.   .|
  Fly   405 CK------FAIDRNSVSNFI------YSRLLGHGR--ADSNDEVLFRGPQ------PKLF---SA 446

  Fly   632 PILLNLNKVQQNAALRALTTSSHLLIKGLPGTGKTQTLVALV-RLLHLLGKSVLITAQTHSAVDN 695
            |.|.:||:.|..|...||..... ||:|.||||||.|...:| :|:.|.|.:||:.|.:::|||.
  Fly   447 PHLPDLNRSQVYAVKHALQRPLS-LIQGPPGTGKTVTSATIVYQLVKLHGGTVLVCAPSNTAVDQ 510

  Fly   696 LIMRLLPFGLPMMRLGSGSR-----------IH------------KQLEEISEER---LTKDCKT 734
            |..::....|.::|:.:.||           :|            |:|:::.:|.   .:.|.|.
  Fly   511 LTEKIHRTNLKVVRVCAKSREAIDSPVSFLALHNQIRNMETNSELKKLQQLKDETGELSSADEKR 575

  Fly   735 VEELEKA-----LGQPSIVGVTCLGCGHPLFQRRQFDYCIVDEATQVLQPTVLRPLIHCSK-FVL 793
            ...|::|     |....::..||:|.|.....|.:|...::||:.|..:|..:.|::..:| .:|
  Fly   576 YRNLKRAAENQLLEAADVICCTCVGAGDGRLSRVKFTSILIDESMQSTEPECMVPVVLGAKQLIL 640

  Fly   794 VGDPEQLPPIVRSKEARQRGADETLFQRLDSEKATAVLSL-------QYRMNKTITRLANELTYG 851
            |||..||.|:|..|:|.:.|..::||:||      .||.:       ||||:..:::..:...|.
  Fly   641 VGDHCQLGPVVMCKKAARAGLSQSLFERL------VVLGIRPFRLEVQYRMHPELSQFPSNFFYE 699

  Fly   852 GDLK---CASDEVSGARFEVELLNEAPRWVQRALTTHLEQAVTLINTGDCLERCQEFVYASQRLV 913
            |.|:   ||.|.    |.:::.     .|.|.                   ||...|:
  Fly   700 GSLQNGVCAEDR----RLKLDF-----PWPQP-------------------ERPMFFL------- 729

  Fly   914 DTCSSIEQSFSEDKDEIRKLTSKKRVSKYTNYCEAGIVMHLLRYLLKSGYEASRIGVIAPYRAQ- 977
                     .::.::||     ....:.:.|..||..|..:....||:|.:..:||:|.||..|
  Fly   730 ---------VTQGQEEI-----AGSGTSFLNRTEAANVEKITTRFLKAGIKPEQIGIITPYEGQR 780

  Fly   978 ------VELFKKLASKLDTDLECNTVDQFQGRDKNLIIYSCSKTGGDFSDMERSREAE---ILED 1033
                  ::....|.|:|..::|..:||.||||:|::||.||          .||.|.:   .|.|
  Fly   781 AYLVQYMQYQGSLHSRLYQEIEIASVDAFQGREKDIIIMSC----------VRSNERQGIGFLND 835

  Fly  1034 QRRLTVAITRAKNKLILLGDIKCLEQYGPFRQLFKHIPD--RCRLKLEEGRMEFGWQRIQEDLV 1095
            .|||.||:||||..:|::|:.|.|.:    :||:.|:.:  :.|..|.||.:    ..::|.|:
  Fly   836 PRRLNVALTRAKFGIIIVGNPKVLAK----QQLWNHLLNFYKDRKVLVEGSL----NNLKESLI 891

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dna2	NP_727386.1	DNA2_N-like	153..378	CDD:411722	6/34 (18%)
		DEXXQc_DNA2	636..836	CDD:350799	70/239 (29%)
		AAA_12	815..1055	CDD:463780	68/259 (26%)
Upf1	NP_572767.1	UPF1_Zn_bind	98..249	CDD:401391	12/78 (15%)
		1B_UPF1-like	302..390	CDD:394815	18/95 (19%)
		TIGR00376	355..880	CDD:273041	162/618 (26%)
		DEXXQc_UPF1	451..684	CDD:350797	70/239 (29%)