DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2990 and Zgrf1

DIOPT Version :9

Sequence 1:	NP_727386.1	Gene:	CG2990 / 31934	FlyBaseID:	FBgn0030170	Length:	1100	Species:	Drosophila melanogaster
Sequence 2:	XP_006233356.1	Gene:	Zgrf1 / 310880	RGDID:	1305834	Length:	2031	Species:	Rattus norvegicus

Alignment Length:	964	Identity:	227/964 - (23%)
Similarity:	364/964 - (37%)	Gaps:	312/964 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   323 KGQLLLYQLMHSAQGRD---TQSGLLLYLKE----GLLREV----ASGRNEQRDLLMLRN-DL-- 373
            ||  :|||.......:|   .|..|.|.|.:    |.||..    ||.....||...:.| ||
  Rat  1135 KG--MLYQQQQDFTSQDLVSRQKALSLNLNQTSRTGELRTALGSSASSNCRVRDGQEINNSDLCF 1197

  Fly   374 --------AYWLTREVAIPASKEDPLEQLPLPEPVYHHSACGNCAYNTICSSFAQKDSSLQLSDS 430
                    ||...|:|.|||..:.|..                  |..|.:|...:..::.|..
  Rat  1198 PNGQKILSAYLPQRQVHIPAVFQSPAH------------------YRQIFTSSIIEHLNILLFG- 1243

  Fly   431 HPLKKLMPQLLEHLSEADHAYVQHWCGLLALEEQHNRQSSH-----------------VRSFWTK 478
                 |..:|.:.||:.|.::.....|.:....::|..|.|                 .|.|:|.
  Rat  1244 -----LAQRLYKALSKVDISFYTSSKGEMMKSGKNNSPSCHHNQPAKLVMVKKEGPNKGRLFYTC 1303

  Fly   479 DPAEREKEGIAIRHLKLVKGQEVILEEGRYRQTLELGE-EADPS---RDL-SLSGFDLGEYVVIS 538
            |..:..:       .|..|..|.:..|       :|.: |:.|:   .|: |:..:...:.:.:.
  Rat  1304 DKPKGNQ-------CKFFKWLEDVTPE-------QLSQNESQPNMIFNDIKSIGSYLRSQKIAVY 1354

  Fly   539 STSRLAVAAGF-------------------IVSIEARRLDLRLER-DLSQRYSE-ETFIIDKHDS 582
            ...:|.:..||                   ..|....:|.|:|.| :.|..||: :.::|.|...
  Rat  1355 EECQLLLRKGFDFQKKQHGKLKKLATVNPEFYSETKSKLYLKLSRKESSSVYSKGDLWVISKTLD 1419

  Fly   583 QSFATF------------------------------NFTNLGMLL----SEGERFQELRDII--- 610
            ....||                              |.|...:|:    :|....|.::|..
  Rat  1420 FELDTFIACSAFFGPSSVNEVELLPLKGYFPSNWPTNITVHALLVCNVSTELTMLQNIQDYFNPA 1484

  Fly   611 ----------------VAKKPPEQHKVLPKII---------LTKGAPI-----LLN---LNKVQQ 642
                            |:.|...:.|.:|..|         |..||.:     |:|   ||..|.
  Rat  1485 TLPLMPYLLAMSQSATVSSKNVSKRKFIPPAITSIKTKFELLHLGATLQLARELINVHRLNNDQA 1549

  Fly   643 NAALR-------------ALTTSSHLL----IKGLPGTGKTQTL-VALVRLLHLLGK-------- 681
            :|.::             ||...||.|    |.|:.|.||:..| |.::.|:.|..|
  Rat  1550 SALMQIAQMMASRGSDEDALEPFSHSLPITVIHGVFGAGKSYLLAVVILFLVELFEKCDSEAVGR 1614

  Fly   682 ----SVLITAQTHSAVDNLIMRLLPFGL-PMMRLGSGSRI---------H----------KQLEE 722
                .:||::.|:.|||.:::.||..|. ..:|:||..:|         |          |:|..
  Rat  1615 ARPWKLLISSSTNVAVDRVLLGLLSLGFEKFIRVGSVRKIAKPVLPYSLHASSDNESEQLKELHA 1679

  Fly   723 ISEERLTK-----DCKTVEELEKA-----LGQPSIVGVTCLGCGHPLFQRRQFDYCIVDEATQVL 777
            :..|.||.     ..|::|:.:..     |.|..:||:||..|..|.....:|...::||.:|:.
  Rat  1680 LMREELTPIERVYVRKSIEQHKLGTNRVLLKQARVVGITCAACPFPCMNDLKFPVVVLDECSQMT 1744

  Fly   778 QPTVLRPL--IHCSKFVLVGDPEQLPPIVRSKEARQ-RGADETLFQRLDSEKATAV-LSLQYRMN 838
            :|..|.|:  ..|.|.:|||||:||||.::..:|.. .|.::|||.||.......: |..|||.:
  Rat  1745 EPASLLPIARFECEKLILVGDPKQLPPTIQGSDAAHGNGLEQTLFDRLCLMGHKPIQLRTQYRCH 1809

  Fly   839 KTITRLANELTYGGDLKCASDEVSGARFEVELLNEAPRWVQRALTTHLEQAVTLINTGDCLERCQ 903
            ..|:.:||:|.|.|:|      |:|..             :|..:..||...||         |.
  Rat  1810 PVISAIANDLFYEGNL------VNGIS-------------ERERSPVLEWLPTL---------CF 1846

  Fly   904 EFVYASQRLVDTCSSIEQSFSEDKDEIRKLTSKKRVSKYTNYCEAGIVMHLLRYLLKSGYEASRI 968
            ..|..::::                        :|.:.:.|..||...:.|:|.|:.||.|.|.|
  Rat  1847 YNVTGTEQV------------------------ERENSFVNVAEAAFTLKLIRSLIASGLEGSMI 1887

  Fly   969 GVIAPYRAQVELFKKLASKLDTD------LECNTVDQFQGRDKNLIIYSCSKTGGDFSDMERSRE 1027
            |||..|::|:.....|.|.:|.|      :|.:|||.|||.:|.:||.||.:|          |:
  Rat  1888 GVITLYKSQMYKICSLLSAVDVDHPDVKAVEVSTVDAFQGAEKEIIILSCVRT----------RQ 1942

  Fly  1028 AEILEDQRRLTVAITRAKNKLILLGDIKCLEQYGPFRQLFKHIPDRCRLKLEEG 1081
            ...::.::|:.||:||.:..|:::|.:.||.:    .||:..:...|:.: |:|
  Rat  1943 VGFIDSEKRMNVALTRGRRHLLIIGSLSCLRK----NQLWGRVIQHCKGR-EDG 1991

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2990	NP_727386.1	Dna2	99..297	CDD:285859
		Cas4_I-A_I-B_I-C_I-D_II-B	<283..415	CDD:294426	29/113 (26%)
		TIGR00376	480..1069	CDD:273041	179/754 (24%)
		P-loop_NTPase	636..859	CDD:304359	85/289 (29%)
		AAA_12	815..1055	CDD:289832	67/246 (27%)
Zgrf1	XP_006233356.1	DUF2439	3..75	CDD:402138
		zf-GRF	1276..1320	CDD:399670	9/50 (18%)
		DEAD-like_helicase_N	1543..1807	CDD:421690	75/263 (29%)
		AAA_12	1784..1968	CDD:404073	66/245 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335135
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830