DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2990 and Mov10

DIOPT Version :9

Sequence 1:	NP_727386.1	Gene:	CG2990 / 31934	FlyBaseID:	FBgn0030170	Length:	1100	Species:	Drosophila melanogaster
Sequence 2:	NP_001101181.1	Gene:	Mov10 / 310756	RGDID:	1598327	Length:	1004	Species:	Rattus norvegicus

Alignment Length:	972	Identity:	220/972 - (22%)
Similarity:	349/972 - (35%)	Gaps:	305/972 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   287 LKGKVDVSVKVKNQRQ-------------REEIIPLELKTGRAS-------FSMEHKGQLLLYQL 331
            |.||..|.|:|:...:             |:|::.|.|:.|...       |.:....|.:.|
  Rat   118 LHGKHGVDVEVQGPHEARDGQLLIRLDLNRKEVLTLRLRNGGTKPVTLTHLFPLCWTPQFVFY-- 180

  Fly   332 MHSAQ------GRDTQSGLLLYLKEG------------LLREVASGRNEQRDLLMLRNDLAYWLT 378
             |..|      |......|.:|.|..            ||....||. |..:...:...||....
  Rat   181 -HGEQDLPCPLGPGESYELHVYCKTSIVGYFPATVLWELLGPGESGA-EGAETFYIARFLAAVAH 243

  Fly   379 REVAIPASKEDPLEQLPLPEPVYHHSACGNCAYNTICSSFAQK------------DSSLQLSDSH 431
            ..:|.......|.::.|            ....|.:.::..::            :.||.|...:
  Rat   244 SPLAAQLKPTTPFKRPP------------RLTRNPVSTNRIEEGERPDRAKGYELELSLALGTYY 296

  Fly   432 P---LKKLMPQLLE----HLSEADHAYVQHWCG--------------LLALEE---QHNRQSSHV 472
            |   |::|:|.||:    ..|..:.|.::....              ||.|||   :|:.:...:
  Rat   297 PPIRLRQLLPTLLQGPSIFTSPKEVAEIKAQLETTLKSRNYEVKLRLLLHLEELQMEHDIRHYDL 361

  Fly   473 RSF-WTKDPAEREKEGIAIRHLKLVKGQEVILEEGRYRQTLELGEEADPSRDLSLSGFDLGEYVV 536
            .|. .|.||.::....:                      |||:....: ||...|.|..|  :.:
  Rat   362 ESVPMTWDPVDQNPRLL----------------------TLEVPGVTE-SRPSVLRGDHL--FAL 401

  Fly   537 ISSTSRL---AVAAGFIVSIEARRLDLRLERDLSQRYSEE-TFIIDKHDSQSFATFNFTNLGMLL 597
            :||..:.   ....||:..:|..|:.|.....|..|:.:. ||.::       .|||
  Rat   402 LSSEIQQEDPVTYKGFVHKVELDRVKLSFSPSLLSRFVDGLTFKVN-------FTFN-------- 451

  Fly   598 SEGERFQELRDIIVAKKPPEQHKVL---------PKI--ILTKGAPIL------------LNLNK 639
                 .|.||         .||:.|         |.:  :.::|..:|            |..|.
  Rat   452 -----RQPLR---------VQHRALELTGRWVLWPTLFPVASRGVSLLPSDVKFKLYDRSLESNP 502

  Fly   640 VQQNA---ALRALTTSSHLLIKGLPGTGKTQTLVALVR--LLHLLGKSVLITAQTHSAVDNLIMR 699
            .|..|   .:|..|..:..:|.|.||||||.|||..::  :.||....:|....::|..|.|..|
  Rat   503 EQLQAMKHIVRGTTRPAPYIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACTPSNSGADLLCQR 567

  Fly   700 LLPFGLPMMRLGSGSRIHKQLEEISEERLT-KDCKT-----------VEELEKALGQPSIVGVTC 752
            |        |:...|.|::.|....:.|:. :|.||           |...:|.|.|..::..|.
  Rat   568 L--------RVHLPSSIYRLLAPSRDIRMVPEDIKTCCNWDPKKGEYVYPAKKHLQQYRVLITTL 624

  Fly   753 LGCGHPL---FQRRQFDYCIVDEATQVLQPTVLRPLIHC----------SKFVLVGDPEQLPPIV 804
            :.....:   |....|.:..:|||...::|..|..:...          .:.||.|||.||.|::
  Rat   625 ITASRLVSAQFPIDHFTHIFIDEAGHCMEPESLVAIAGLMDVKETGNPGGQLVLAGDPRQLGPVL 689

  Fly   805 RSKEARQRGADETLFQRL--------------DSEKATAVLSLQYRMNKTITRLANELTYGGDLK 855
            ||..|::.|...:|.:||              |.:..|.:|. .||.:.||..:.|:|.|.|:|:
  Rat   690 RSPLAQKHGLGYSLLERLLTYNSLYKKGPNGYDPQFITKLLR-NYRSHPTILDIPNQLYYDGELQ 753

  Fly   856 CASDEVSGARFEVELLNEAPRWVQRALTTHLEQAVTLINTGDCLERCQEFVYASQRLVDTCSSIE 920
            ..:|.|...||        .||  ..|.   :|...:|..|
  Rat   754 ACADVVDRERF--------CRW--EGLP---QQGFPIIFHG------------------------ 781

  Fly   921 QSFSEDKDEIRKLTSKKRVSKYTNYCEAGIVMHLLRYLL-------KSGYEASRIGVIAPYRAQV 978
               ...||| |:..|    ..:.|..||..|...||.||       |:......:|||:|||.||
  Rat   782 ---VMGKDE-REGNS----PSFFNPEEAATVTSYLRQLLAPSSKKGKARLSPRSVGVISPYRKQV 838

  Fly   979 ELFKKLASKLD---------TDLECNTVDQFQGRDKNLIIYSCSKTGGDFSDMERSREAEILEDQ 1034
            |..:...:|||         .||:..:|::|||:::::|:.|..::...|..::.......|::.
  Rat   839 EKIRYCITKLDRELRGLDDIKDLKVGSVEEFQGQERSVILISTVRSSQSFVQLDLDFNLGFLKNP 903

  Fly  1035 RRLTVAITRAKNKLILLG---------DIK-----CLEQYGPFRQLFKHIPDRCRLKLEEGR 1082
            :|..||:||||..||::|         |.|     |.|..|     :...|...:|.|::|:
  Rat   904 KRFNVAVTRAKALLIVVGNPLLLGHDPDWKTFLEFCKENGG-----YTGCPFPAKLDLQQGQ 960

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2990	NP_727386.1	Dna2	99..297	CDD:285859	5/9 (56%)
		Cas4_I-A_I-B_I-C_I-D_II-B	<283..415	CDD:294426	31/165 (19%)
		TIGR00376	480..1069	CDD:273041	165/689 (24%)
		P-loop_NTPase	636..859	CDD:304359	71/266 (27%)
		AAA_12	815..1055	CDD:289832	72/278 (26%)
Mov10	NP_001101181.1	DEXXQc_Helz-like	499..734	CDD:350796	62/243 (26%)
Mov10	NP_001101181.1	SF1_C_Upf1	735..940	CDD:350195	65/249 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810