DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2990 and Dna2

DIOPT Version :9

Sequence 1:	NP_727386.1	Gene:	CG2990 / 31934	FlyBaseID:	FBgn0030170	Length:	1100	Species:	Drosophila melanogaster
Sequence 2:	NP_001376551.1	Gene:	Dna2 / 309762	RGDID:	1306791	Length:	1059	Species:	Rattus norvegicus

Alignment Length:	1093	Identity:	355/1093 - (32%)
Similarity:	565/1093 - (51%)	Gaps:	135/1093 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 DDFDLALI---AAMDSISNHRLELTKWQ----------------RCEVVRLEQLPNRKG-----L 88
            ||.||.|:   :..:::.  |:|:.:.:                |..|:.:|...|.:|     |
  Rat     5 DDLDLLLLEEDSGAEAVP--RMEILQKKADAFFAETVLSRGVDNRYLVLAVETKLNERGAEEKHL 67

  Fly    89 KVHVKRISGGDPETADCQLLPPWNCMPMQVGDTVSLLGKWDPSAGCYVVDKEQGYCVSHPDFLIS 153
            .:.|.:  .|:.|.. |.|...|:.:|::.||.:.:.|  |.::..::||.:.||.:..||.|||
  Rat    68 LITVSQ--EGEQEVL-CILRNGWSSVPVEPGDIIHIEG--DCTSEPWIVDDDFGYFILSPDMLIS 127

  Fly   154 GTTVTGSLFCKRKSVLQERFRGLDSGNSVMVIGTLVHELLQKVLRQKLFDKKHIQSALQEMLASS 218
            ||:|..|:.|.|::||.|.||..|:....|:|||::||:.||.:.:....:|..:.|||.:   .
  Rat   128 GTSVASSIRCLRRAVLSETFRVSDTATRQMLIGTILHEVFQKAISESFAPEKLQELALQTL---R 189

  Fly   219 SLAHL--LYASNL----IQVEMEDHLMKFIDPIVSFVAQYVKGEPPSVLLP-------------- 263
            .:.||  :|..||    ::.|:|::|..|......|:.:..|.|.|.:.|.
  Rat   190 EVRHLKEMYRLNLSQDEVRCEVEEYLPSFSKWADEFMHKGTKAEFPQMHLSLPSDSSDRSSPCNI 254

  Fly   264 EVYRGQIHEICDIEENLWVPQLGLKGKVDVSVKVKNQRQ---REEIIPLELKTGRASFSMEHKGQ 325
            ||.:.     .||||::|.|:.|||||:||:|.||..|.   :.:|:|||||||:.|.|:||:||
  Rat   255 EVVKS-----LDIEESIWSPRFGLKGKIDVTVGVKIHRDCKTKYKIMPLELKTGKESNSIEHRGQ 314

  Fly   326 LLLYQLMHSAQGRDTQSGLLLYLKEGLLREVASGRNEQRDLLMLRNDLAYWLTREVAIPASKEDP 390
            ::||.|:...:..|.::|.|||||.|.:..|.:...::|:||.|||.||:.|...|:..|:.|:
  Rat   315 VILYTLLSQERREDPEAGWLLYLKTGQMYPVPANHLDKRELLKLRNQLAFSLLHRVSRAAAGEE- 378

  Fly   391 LEQLPLPEPVYHHSACGNCAYNTICSSFAQ-----KDSSLQLSDSHPLKKLMPQLLEHLSEADHA 450
            ...|.||:.:.....|..|:....|:.:::     .|:|:    ...::..:.:..:||:.|...
  Rat   379 ARLLALPQIIEEEKTCKYCSQMGNCALYSRAVEQVHDTSI----PEGMRSKIQEGTQHLTRAHLK 439

  Fly   451 YVQHWCGLLALEEQHNRQSSHVRSFWTKDPAEREKEGIAIRHLKLVKGQEV-ILEEGRYRQTLEL 514
            |...||.:|.||.|........:|.|....::.|:.|..|.  .||:.:.| .:.:|.|....:.
  Rat   440 YFSLWCLMLTLESQSKDTKKSHQSIWLTPASKLEESGNCIG--SLVRTEPVKRVCDGHYLHNFQR 502

  Fly   515 GEEADPSRDLSLSGFDLGEYVVISSTSR--LAVAAGFIVSIEARRLDLRLERDLSQRYSEETFII 577
            .....|:.:|.     .|:.:::|...|  .|::.|::..|:...:...|:|:||.......|.:
  Rat   503 KNGPMPATNLM-----AGDRIILSGEERKLFALSKGYVKRIDTAAVTCLLDRNLSTLPETTLFRL 562

  Fly   578 DKHDSQSFATFNFTNLGMLLSEGERFQELRDIIVAKKPPE----QHKVLPKIILTKGAPILLNLN 638
            |:.:..........||..|:...:..:.||::|:..|.|:    ...|||.......|.||..||
  Rat   563 DREEKHGDINTPLGNLSKLMENTDSSKRLRELIIDFKEPQFIAYLSSVLPHDAKDTVANILKGLN 627

  Fly   639 KVQQNAALRALTTSSHLLIKGLPGTGKTQTLVALVRLLHLLGKSVLITAQTHSAVDNLIMRLLPF 703
            |.|:.|..:.|.:..:.||.|:||||||.|:.||||:|...|.|||:|:.|||||||::::|..|
  Rat   628 KPQRQAMKKVLLSKDYTLIVGMPGTGKTTTICALVRILSACGFSVLLTSYTHSAVDNILLKLAKF 692

  Fly   704 GLPMMRLGSGSRIHKQLEEISEERL--TKDCKTVEELEKALGQPSIVGVTCLGCGHPLFQRRQFD 766
            .:..:|||...::|..:::.:||.:  .:...::..||:......:|..||:|..||:|.|:.||
  Rat   693 KIGFLRLGQSHKVHPDIQKFTEEEMCRLRSIASLAHLEELYNSHPVVATTCMGISHPMFSRKTFD 757

  Fly   767 YCIVDEATQVLQPTVLRPLIHCSKFVLVGDPEQLPPIVRSKEARQRGADETLFQRLD-SEKATAV 830
            :||||||:|:.||..|.||....:||||||.:||||:|.::|||..|..|:||:||: :|.|...
  Rat   758 FCIVDEASQISQPICLGPLFFSRRFVLVGDHKQLPPLVLNREARALGMSESLFKRLERNESAVVQ 822

  Fly   831 LSLQYRMNKTITRLANELTYGGDLKCASDEVSGARFEVELLNEAPRWVQRALTTHLEQAVTLINT 895
            |::|||||:.|..|:|:|||.|.|:|.||.|:.|                        .:||.|.
  Rat   823 LTIQYRMNRKIMSLSNKLTYEGKLECGSDRVANA------------------------VITLPNL 863

  Fly   896 GDC-LERCQEFVYASQRLVDTCSSIEQSFSEDKD----EIRKLTSKKRVSK--YTNYCEAGIVMH 953
            .|. ||     .||........:.:   |..|..    ...|:.:.:::..  .:|..||.:::.
  Rat   864 KDVRLE-----FYADYSDNPWLAGV---FEPDNPVCFLNTDKVPAPEQIENGGVSNVTEARLIVF 920

  Fly   954 LLRYLLKSGYEASRIGVIAPYRAQVELFKKLASKLDTDL-ECNTVDQFQGRDKNLIIYSCSKTGG 1017
            |....:|:|...|.||:|||||.|:.....|.::....: |.||||::|||||:||:.|..::..
  Rat   921 LTSTFIKAGCSPSDIGIIAPYRQQLRTITDLLARSSVGMVEVNTVDKYQGRDKSLILVSFVRSNE 985

  Fly  1018 DFSDMERSREAEILEDQRRLTVAITRAKNKLILLGDIKCLEQYGPFRQLFKHI 1070
            |      ....|:|:|.|||.|||||||:||||||.:..|:::.|..:||.|:
  Rat   986 D------GTLGELLKDWRRLNVAITRAKHKLILLGSVSSLKRFPPLEKLFDHL 1032

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2990	NP_727386.1	Dna2	99..297	CDD:285859	72/217 (33%)
		Cas4_I-A_I-B_I-C_I-D_II-B	<283..415	CDD:294426	55/134 (41%)
		TIGR00376	480..1069	CDD:273041	206/606 (34%)
		P-loop_NTPase	636..859	CDD:304359	102/225 (45%)
		AAA_12	815..1055	CDD:289832	86/248 (35%)
Dna2	NP_001376551.1	Nuclease activity. /evidence=ECO:0000250	82..519		142/458 (31%)
		DNA2_N-like	127..366	CDD:411722	92/246 (37%)
		Helicase activity. /evidence=ECO:0000250	520..1059		196/551 (36%)
		DEXXQc_DNA2	625..828	CDD:350799	89/202 (44%)
		AAA_12	805..1017	CDD:404073	86/249 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	127	1.000	Domainoid score	I5254
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6124
Inparanoid	1	1.050	505	1.000	Inparanoid score	I1289
OMA	1	1.010	-	-		QHG56923
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002978
OrthoInspector	1	1.000	-	-		oto95748
orthoMCL	1	0.900	-	-		OOG6_102643
Panther	1	1.100	-	-	LDO	PTHR10887
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1978
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.970