DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2990 and Helz

DIOPT Version :9

Sequence 1:	NP_727386.1	Gene:	CG2990 / 31934	FlyBaseID:	FBgn0030170	Length:	1100	Species:	Drosophila melanogaster
Sequence 2:	XP_008766536.1	Gene:	Helz / 287773	RGDID:	1307049	Length:	1981	Species:	Rattus norvegicus

Alignment Length:	1245	Identity:	255/1245 - (20%)
Similarity:	397/1245 - (31%)	Gaps:	453/1245 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MATKRVLTPNILENDNTDVTSSNPQKKFKEQLDFSSDEVENIDWG---------------DNDDF 50
            |.||.:.....|..:....||:.|          |...||::|.|               .::::
  Rat   127 MVTKDLTRLKTLLAETETATSNAP----------SGCHVEDLDEGSCNGWHFRPPPRGITSSEEY 181

  Fly    51 DL---------ALIAAMDSISNHRLELTKWQRCEVVRLEQLPNRKGLKVHVKRISGGDPETADCQ 106
            .|         ....|..:.::.:.||.:||:....||.:|..:.    ..|::||...||
  Rat   182 TLCKRFLEQGICRYGAQCTSAHSQEELAEWQKRYASRLIKLKQQS----ENKQLSGSYMET---- 238

  Fly   107 LLPPWNCMPMQVGDTVSLLGKWDPSAGCYVVDKE--QGYCVSH-PDFLI------SGTTVTGSLF 162
                             |:.||..|.....|..|  :|..|.| ||..:      |..|.|.:|.
  Rat   239 -----------------LIEKWMSSLSPEKVLSECLEGVQVEHSPDLSVTVNTKKSHQTWTFALT 286

  Fly   163 CK------RKSVLQERFR------GLDSGNSVMVIGTLVHELLQKVLRQKLFDKKHIQSALQEML 215
            ||      |.::|.:..|      .:.:|:|...:...|.|              :.|..:...:
  Rat   287 CKPARMLCRVALLYDAHRPHFSIIAISAGDSTAQVSQEVPE--------------NCQEWIGGEM 337

  Fly   216 ASSSLAHLLY----ASN-----------LIQVEMEDHLMK--FIDPIVSFVAQYV---------- 253
            |.:.|.|.:|    |.|           :....:|..||:  .||...:...:|:
  Rat   338 AQNGLDHYVYKVGIAFNTEIFGTFRQTIVFDFGLEPVLMQRVMIDAASTEDLEYLMHAKQQLVTT 402

  Fly   254 --KGEPPSVLLPEVYRGQIHEICDIEENL---WVPQLGLKGKVDVSVKVKNQRQREEIIPLELKT 313
              :.||.|           ..|.|.|.|.   |
  Rat   403 ARRWEPSS-----------KTIVDFEPNETTDW-------------------------------- 424

  Fly   314 GRASFSMEHKGQLLLYQLMHSAQGRDTQSGLLLYLKEGLLREVASGRNEQRDLLMLRNDLAYWLT 378
                    .|..|:.||:..||....|||    .|.:.|.:  .:.::...|||.:.....|
  Rat   425 --------EKSLLIRYQIPLSADQLFTQS----VLDKSLTK--TNYQSRLHDLLYIEEIAQY--- 472

  Fly   379 REVAIPASKEDPLEQLPLPEPVYHHSACGNCAYNTICSSFAQKDSSLQLSDSHPLKKLMPQLLEH 443
            :||    |:.:.:|  |:..|:..|           |:.|..| ..||:..|..|..:.
  Rat   473 KEV----SRLNGIE--PVKVPICVH-----------CAKFNLK-VQLQILASFMLTGVS------ 513

  Fly   444 LSEADHAYVQHWCGLLALEEQHNRQSSHVRSFWTKD------PAEREKEGIAIRHLKLVKGQEVI 502
             ..|.:|......|...|.|..:..:...|...|:.      |..:|         |||:.|..
  Rat   514 -GGAKYAQNGQLFGRFKLTETLSEDTLAGRLVMTRVNAVYLLPVPKE---------KLVQSQGT- 567

  Fly   503 LEEGRYRQTLELGEEADPSRDLSLSGFDLGEYVVISSTSRLAVAAGFIVSIEARRLDLRLERDLS 567
             :|..|..|:|     :.::|          ||.                       ||:.|:.
  Rat   568 -KEKVYEATIE-----EKTKD----------YVF-----------------------LRISREC- 592

  Fly   568 QRYSEETFIIDKHDSQSFATFNFTNLGMLLSEGERFQELRDIIVAKKPPEQHKVL---------- 622
               .||..:....|:|....|....|.:.                    |.|..|
  Rat   593 ---CEELSLRPDCDTQVELQFQLNRLPLC--------------------EMHYALDRIKDNGVLF 634

  Fly   623 PKIILTKGAPILLN----------LNKVQQNAALRALTTS-----SHLLIKGLPGTGKTQTLVAL 672
            |.|.:|...|...|          ||..|:.|.| |:||.     ..:||.|..|||||.||...
  Rat   635 PDISMTPTIPWSPNRQWDEQLDPRLNAKQKEAVL-AITTPLCIQLPPVLIIGPYGTGKTFTLAQA 698

  Fly   673 VRLLHLLGKS----VLITAQTHSAVDNLIMRLL-PFGLPMMRLGSGSRIHKQLEEISEERLTKDC 732
            |:  |:|.:.    :||...::||.|..|...| |:      :.:|:...:.|......|..
  Rat   699 VK--HILQQQETSRILICTHSNSAADLYIKDYLHPY------VEAGNAQARPLRVYFRNRWV--- 752

  Fly   733 KTVEELEKALGQPSIVGVTCL-GCGHPLFQRRQ-----------------------------FDY 767
            |||.         .:|...|| ...|..||..|                             |.:
  Rat   753 KTVH---------PVVHQYCLISSAHSTFQMPQKEDILKHRVVVVTLNTSQYLCQLDLEPGFFTH 808

  Fly   768 CIVDEATQVLQPTVLRPLIHCSK---FVLVGDPEQLPPIVRSKEARQRGADETLFQRL----DSE 825
            .::|||.|.::...:.||...:|   .||.||..||.|.|.|:.||:|....:|..||    .:|
  Rat   809 ILLDEAAQAMECETIMPLALATKNTRIVLAGDHMQLSPFVYSEFARERNLHVSLLDRLYEHYPAE 873

  Fly   826 KATAVLSLQ-YRMNKTITRLANELTYGGDLKCASDEVSGARFEVELLNEAPRWVQRALTTHLEQA 889
            ....:|..: ||.::.|....:||.|.|.|..:..:.:...|          :.....|...|
  Rat   874 FPCRILLCENYRSHEAIINYTSELFYEGKLMASGKQPAHKDF----------YPLTFFTARGE-- 926

  Fly   890 VTLINTGDCLERCQEFVYASQRLVDTCSSIEQSFSEDKDEIRKLTSKKRVSKYTNYCEAGIVMHL 954
                   |..|:.....|.:..:.:....:|        |:|:
  Rat   927 -------DVQEKNSTAFYNNAEVFEVVERVE--------ELRR---------------------- 954

  Fly   955 LRYLLKSG-YEASRIGVIAPYRAQV-----ELFKKLASKLDTDLECNTVDQFQGRDKNLIIYSCS 1013
             ::.:..| .:...|||:.||..||     ||.||..|    |:....|...||:...::..|..
  Rat   955 -KWPVAWGKLDDGSIGVVTPYADQVFRIRAELRKKRLS----DVNVERVLNVQGKQFRVLFLSTV 1014

  Fly  1014 KTGGDFSDMER--SREAEILEDQ------------RRLTVAITRAKNKLILLGDIKCLEQYGPFR 1064
            :|.......:.  .::.::|||.            :.|..|||||::.:.::||...|...|..|
  Rat  1015 RTRHTCKHKQTPIKKKEQLLEDSTEDLDYGFLSNYKLLNTAITRAQSLVAVVGDPVALCSIGRCR 1079

  Fly  1065 QLFKHIPDRC 1074
            :.::.....|
  Rat  1080 KFWERFIALC 1089

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2990	NP_727386.1	Dna2	99..297	CDD:285859	47/250 (19%)
		Cas4_I-A_I-B_I-C_I-D_II-B	<283..415	CDD:294426	22/131 (17%)
		TIGR00376	480..1069	CDD:273041	147/676 (22%)
		P-loop_NTPase	636..859	CDD:304359	76/280 (27%)
		AAA_12	815..1055	CDD:289832	52/264 (20%)
Helz	XP_008766536.1	zf-CCCH	181..205	CDD:395517	2/23 (9%)
		DEXXQc_HELZ	658..885	CDD:350835	67/247 (27%)
		SF1_C_Upf1	886..1086	CDD:350195	48/253 (19%)
		Atrophin-1	<1195..>1536	CDD:397323
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810