DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2990 and Setx

DIOPT Version :9

Sequence 1:	NP_727386.1	Gene:	CG2990 / 31934	FlyBaseID:	FBgn0030170	Length:	1100	Species:	Drosophila melanogaster
Sequence 2:	XP_006498142.1	Gene:	Setx / 269254	MGIID:	2443480	Length:	2701	Species:	Mus musculus

Alignment Length:	1444	Identity:	276/1444 - (19%)
Similarity:	476/1444 - (32%)	Gaps:	516/1444 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 VTSSNPQK--------KFKEQLDFSSDEVENIDWGDNDDFDLALIAAMDSISNHRLELTKWQRCE 75
            ||:.:||:        :..::.|.:..::::.|.|          .|..|.|..| :.|..|:..
Mouse  1159 VTAEDPQRPSSSVGTDQLPDRRDLTESDLKSADMG----------MATPSSSVER-DSTILQKST 1212

  Fly    76 VVRLEQLPNRK------GLKVHVKRISGGDPETA--DCQ----LLPPWNCMPM-QVGDTVSLLG- 126
            ..|....|.||      ..|.|.....|....:.  .|:    ::||...... :...||..||
Mouse  1213 KSRTHSKPVRKVPASKATKKTHSDTRRGQSKSSCYISCRTSPAIVPPKKLRQCPEPTSTVEKLGL 1277

  Fly   127 KWDP---------SAGCYVVDKEQGYCVSHPDF-----LISGTTVTGSLFCKRKSVLQERFRGLD 177
            |..|         |..|.|..::.|..|...|.     |||..|:  |:...:|.:..:..:
Mouse  1278 KKAPRKAFELSQRSLECIVQLRDHGKTVGVVDAPKKAKLISPQTL--SIKNNKKLLTSQDLQ--- 1337

  Fly   178 SGNSVMVIGTLVHELLQKVLRQKL-----FDKKHIQSALQEMLASSSLAHLLYASNLIQV---EM 234
                           .|:::|.:.     ||.|:..:.        .::.::..|::::.   |.
Mouse  1338 ---------------FQRLMRSRSHKKRDFDYKNTDTV--------RVSRIVQGSDVLEADSDEP 1379

  Fly   235 EDHLMKFIDPI-VSFVAQYVKGEPPSVLLPEVYRGQIHEICDIEENLWVPQLG----------LK 288
            :||  :..:|: :|...|..|     .:|.:.      |:.:...:.||..:.          |.
Mouse  1380 DDH--RVSEPLAISNEKQLAK-----CMLSKT------EVAEASSDPWVTGITCLVNQCESRVLS 1431

  Fly   289 GKVDVSVKVKNQR-----------QREEIIPLELKTGRASFSMEHKGQLLLYQLMHSAQGRDTQS 342
            |.|...|.:.:..           |..|:..::.....:|...:....|.|.|  |..|..|..|
Mouse  1432 GGVPTDVVMVSASEDPVDGGAVTVQVGEVASVKAAEPASSSDTDDDDNLFLTQ--HDPQDMDLCS 1494

  Fly   343 GL------LLYLKEGLLREVASGRNEQRDLLM-----------LRNDLAY------------WLT 378
            .|      :.:.|:.:.||.:..|.:...|.:           .:|...|            .|.
Mouse  1495 QLENKTIIVAHKKDTVQREDSLSRPQLESLSITKCKYKDCVETTKNQGEYCPRHSEAKAADDGLF 1559

  Fly   379 REVAIPASKEDPLEQLPLPEPVYHHSACGNCA------YNTICSSFAQKDSSLQLSDSHP-LKKL 436
            |:..:|.|...||.  |....::..|:....|      .:|.....|.|:.|   |.:.| ||..
Mouse  1560 RKPGLPLSVARPLR--PTTTKIFSSSSASRTANLSKSLESTTLQQSALKNKS---SGAQPNLKVT 1619

  Fly   437 MPQLLEHLSEADHAYVQHWCGLLALEEQHNRQSSHVRSFWTKDPAEREKEGIAIRHLKLVKGQEV 501
            .|..:.  |:...|.|:..|.:...:...:......:..::::........:.|    |:..|.:
Mouse  1620 PPSSMG--SQKPVAEVKSLCNIFHFQTPSSSSKQSCKLTFSENRPTSAASPVNI----LLPSQSI 1678

  Fly   502 I------LEEGRYRQTLELGEEADP-------SRDLSLSGFDLGEY-------VVISSTSRLAVA 546
            .      :.:.:|:..|...:...|       ||.:.:...|..||       :::::...:|..
Mouse  1679 FDTFIKEVLKWKYQMFLNFDKCGAPTSLCQSISRPVPVRFQDCAEYFNVFLPLIILNAFETVAQE 1743

  Fly   547 -------------------------AGFIVSIEARRLDLRL---ERDLSQRYSEETFIIDKHDSQ 583
                                     ..|::.:....|..:|   |.||.....|::: :|:|..|
Mouse  1744 WLSSPNKENFYQLQLRKFPADYKKYWEFLIYLNESELAKQLHPKENDLVFLAPEKSY-MDRHGMQ 1807

  Fly   584 SFATF------NFTNLGMLLSEGERFQEL----------------RDIIVAKKPPEQHKV----- 621
            ..:.:      .|....::.| |:....|                |.|:::.....|.|:
Mouse  1808 DCSHYYCGYVHKFRRTSVMRS-GKAECSLCIQTQDTLPASVKNLTRCIVISSLVTTQRKLKAMSL 1871

  Fly   622 ------LPKIIL--------TKG---------APILLNLNKVQQNAALRALTTSSH-------LL 656
                  |.:.:|        ||.         ...|.:.|:.|:.|...|.....|       .|
Mouse  1872 LSSRNQLARAVLNPNPMDFCTKDLLTTTSERIVAYLKDFNEDQKKAIETAYAMVKHSPSVAKICL 1936

  Fly   657 IKGLPGTGKTQTLVALV-RLL---------------HLLGKSVLITAQTHSAVDNLIMRLL---- 701
            |.|.|||||::|:|.|: |||               .:....||:.|.:::|||.|:.:::
Mouse  1937 IHGPPGTGKSKTIVGLLYRLLTENQRKGHSDENFNAKIKQNRVLVCAPSNAAVDELMKKIILEFK 2001

  Fly   702 --------PFG----LPMMRLGSGSRI--------------HK---------------------Q 719
                    |.|    :.::|||....|              |:                     |
Mouse  2002 EKCKDKKNPLGNCGDINLVRLGPEKSINTEVLKFSLDSQVNHRMKKDLPSHIQEMLRRKEILDAQ 2066

  Fly   720 LEEISEERLTKDCKTVEELEK-----------------------ALGQPS-----------IVGV 750
            |:|:|.:|..  |:...|:::                       ..|:|.           ::..
Mouse  2067 LDELSRQRAL--CRGGREMQRQELDEHIAIVSKERQELASKIKEVQGRPQRAQNTIILESHVICC 2129

  Fly   751 TCLGCGHPLFQ---RRQ----FDYCIVDEATQVLQPTVLRPLIH-CSKFVLVGDPEQLPPIVRSK 807
            |....|..|.:   |.|    |...|||||.|..:...|.|||| |:|.:|||||:||||.|.|.
Mouse  2130 TLSTSGGLLLESAFRGQGGVPFSCVIVDEAGQSCEVETLSPLIHRCNKLILVGDPKQLPPTVISM 2194

  Fly   808 EARQRGADETLF------------QRLDSEKATAVLSLQYRMNKTITRLANELTYGGDLKCASDE 860
            :|::.|.|:::.            |.:........|::||||:..|....:...|..:||
Mouse  2195 KAQEYGYDQSMMARFCKLLEENVEQNMIGRLPVLQLTIQYRMHPDICLFPSNYVYNKNLK----- 2254

  Fly   861 VSGARFEVELLNEAPRWVQRALTTHLEQAVTLINTGDCLERC-QEFVYASQRLVDTCSSIEQSFS 924
                                  |..|.:::          || .|:.:....:.|.....|:
Mouse  2255 ----------------------TNRLTESI----------RCSSEWPFQPYLVFDVGDGSER--- 2284

  Fly   925 EDKDEIRKLTSKKRVSKYTNYCEAGIVMHLLRYLLKSGYEAS--RIGVIAPYRAQVELFKK---- 983
            .|.|            .|.|..|..:||.:::.:.:...:.|  .||:|..|:||..:.:|
Mouse  2285 RDND------------SYINVQEIKLVMEIIKLIKEKRKDISFRNIGIITHYKAQKTMIQKDLEK 2337

  Fly   984 ---------------------------------------LASKLDTD---------------LEC 994
                                                   |.|...|.               .|.
Mouse  2338 EFDKKGLLQPIMMGESRQQDSEASKQQQKSSEFMHASDELGSSTVTQSGISSLENGATHTGPAEV 2402

  Fly   995 NTVDQFQGRDKNLIIYSCSKTGGDFSDMERSREAEILEDQRRLTVAITRAKNKLILLGDIKCLEQ 1059
            :|||.||||.|:.||.:|.:.    |.::.|  ...|...:||.|.|||||..|.:||.::.|.:
Mouse  2403 DTVDAFQGRQKDCIIVTCVRA----SAVQGS--IGFLASLQRLNVTITRAKYSLFILGHLRTLME 2461

  Fly  1060 YGPFRQLFKHIPDR 1073
            ...:.:|.:....|
Mouse  2462 NQHWYELIQDAQKR 2475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2990	NP_727386.1	Dna2	99..297	CDD:285859	42/238 (18%)
		Cas4_I-A_I-B_I-C_I-D_II-B	<283..415	CDD:294426	32/187 (17%)
		TIGR00376	480..1069	CDD:273041	173/875 (20%)
		P-loop_NTPase	636..859	CDD:304359	85/350 (24%)
		AAA_12	815..1055	CDD:289832	62/312 (20%)
Setx	XP_006498142.1	SEN1_N	37..>334	CDD:372274
		DEXXQc_SETX	1910..2235	CDD:350800	78/326 (24%)
		AAA_12	2201..2455	CDD:372468	61/311 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831386
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740