Protein Alignment CG2990 and dna2

DIOPT Version :9

• Sequence 1: NP_727386.1
• Gene: CG2990 / 31934
• FlyBaseID: FBgn0030170
• Length: 1100
• Species: Drosophila melanogaster
• Sequence 2: NP_596499.2
• Gene: dna2 / 2540148
• PomBaseID: SPBC16D10.04c
• Length: 1397
• Species: Schizosaccharomyces pombe
• Alignment Length: 1183
• Identity: 329/1183 - (27%)
• Similarity: 509/1183 - (43%)
• Gaps: 262/1183 - (22%)

  Fly    46 DNDDFDLAL--IAAMDSISNHRLELTKWQRCEVVRLEQLPN----------RKGLKV-HVKRISG 97
            |.|||.|..  :||:||:..              :..||||          .|..|| ||    |
pombe   251 DEDDFALEAEDLAALDSLER--------------QYSQLPNSTVTASAKDIEKTAKVNHV----G 297

  Fly    98 GD-------PETAD---------------CQLLPPWN-------------CMPMQ---------- 117
            ||       .:.:|               |..||..|             |.|.:
pombe   298 GDLQSYCSATKASDATINEEPVNLALDKACNSLPDINSDFIDDWDDSCDGCTPGELCEFSSEYTV 362

  Fly   118 -------------------------------------------VGDTVSLLGKWDPSAGCYVVDK 139
                                                       |||::.:...:|.. ...:||.
pombe   363 LEVHEDFIFHEGNHFRQLKLILEANDILHQLFLRGDWTETSIFVGDSIRVEATFDKD-NTAIVDN 426

  Fly   140 EQGYCVSHPDFLISGTTVTGSLFCKRKSVLQERFRGLDSGNSVMVIGTLVHELLQKVLRQKLFDK 204
            ::|..:.||..|:|.|.|..|..|.||:|:.:|..........||.|.::|:..|..|.:.:
pombe   427 DKGLIIIHPKILMSATAVASSFPCLRKAVISDRVGIYGPPTKAMVTGNILHDFFQHALYRGI--- 488

  Fly   205 KHIQSALQEM---LASSSLAHL--LYASNLIQVEMEDHLMKFIDPIVSFVAQYVKGEPPSVLLPE 264
                .||:.:   |.:|...::  :|.::|...|:.:.|...:..:.|.|.:|:..:........
pombe   489 ----DALENVDINLETSIKTYISDIYFADLSLDEIREELDARLPLLKSIVERYLISKKNDNNNES 549

  Fly   265 VYRGQIHEICDIEENLWVPQLGLKGKVDVSVKV----KNQRQREEIIPLELKTGRASFSMEHKGQ 325
            ::   |..:.||||::|.|:.||||.:|.:|:|    |.:......:||||||||...::.|..|
pombe   550 IH---ISRLLDIEESIWSPRFGLKGNIDATVEVVLTEKPESSSTLTLPLELKTGRYVDNISHFAQ 611

  Fly   326 LLLYQLMHSAQ-GRDTQSGLLLYLKEGLLREVASGRNEQRDLLMLRNDLAYWLTREVAIPASKED 389
            .|||.|:.|.: |.:|...||.||:...::.:.:..::.|.|:|.||.||....|.
pombe   612 SLLYTLLISDRYGINTNQALLCYLENSTIKNLVASNSQLRGLIMTRNSLAQHNFRR--------- 667

  Fly   390 PLEQLPLPEPVYHHSACGNCAYNTICSSFAQKDSSLQLSDSHPLKKLMPQLLEHLSEADHAYVQH 454
                 .|||.:.:...|.:|:..:.| .|.||.|...:::|:.|.:...:.:..:.:.|..:.:.
pombe   668 -----SLPEMISNRKICDHCSLVSEC-LFFQKMSDKGVANSNGLTESWNEWMREVKDEDLEFYKK 726

  Fly   455 WCGLLALEEQ-HNRQSSHVRSFWTKDPAEREKEGIAIRHLKLVKGQEVILE-EGR---YRQTLEL 514
            |..||..||: ...:...|.:|   |..|.|..|..:..|.:.|...|.|| :.|   |:... |
pombe   727 WEKLLNQEERLLLLKRGDVLTF---DTEELEAYGKTLYPLYITKEDIVCLEIDDRVFHYKFAF-L 787

  Fly   515 GEEADPSRDLSLSGFDLGEYVVISST-SRLAVAAGFIVSIEARRLDLRLERDL------------ 566
            .:...| |:...|||.:||.|.||.. ...::|.|.||.|:...:::|....|
pombe   788 NDNGYP-RNFLHSGFSVGERVFISDEHGHWSLAKGHIVHIQDSCIEVRTRHRLHIPWLKMPNFDF 851

  Fly   567 --------SQRYSEETFI--------IDKHD-SQSFATFNFTNLGMLLSEGERFQELRDIIVAKK 614
                    :...|:.:||        |||.: |...|:...|.:..:|.:....  :||:|:..|
pombe   852 KKNQVFFGNYEDSKLSFIGSNHTRYRIDKDEFSSGIASIRGTLMSSVLPDAPLI--IRDMIIRLK 914

  Fly   615 PPEQHKVLPKIILTKGAPILLNLNKVQQNAALRALTTSSHL-LIKGLPGTGKTQTLVALVRLLHL 678
            ||   |.....::.   |..|......|..||:....:.|. ||.|:||||||.|:.:|:|.|..
pombe   915 PP---KFCNSALID---PEFLKCLNEDQITALKKCHAAEHYSLILGMPGTGKTTTISSLIRSLLA 973

  Fly   679 LGKSVLITAQTHSAVDNLIMRLLPFGLPMMRLGSGSRIHKQLEEIS-EERLTKDCKTVEELEKAL 742
            ..|.:|:|:.||.||||::::|......::||||..:||..::|.. .|..|.|  .:..|:...
pombe   974 KKKKILLTSFTHLAVDNILIKLKGCDSTIVRLGSPHKIHPLVKEFCLTEGTTFD--DLASLKHFY 1036

  Fly   743 GQPSIVGVTCLGCGHPLFQRRQFDYCIVDEATQVLQPTVLRPLIHCSKFVLVGDPEQLPPIVRSK 807
            ..|.||..:.||..|.:|.:|:|||||:|||:|:..|..|.||....|||||||..||||:|::.
pombe  1037 EDPQIVACSSLGVYHSIFNKRKFDYCIIDEASQIPLPICLGPLQLAEKFVLVGDHYQLPPLVKNS 1101

  Fly   808 EARQRGADETLFQRLDSEK---ATAVLSLQYRMNKTITRLANELTYGGDLKCASDEVSGARF--- 866
            ...:.|...:||:.| |||   |...|.||||||:.|..|::||.|||:|.|.|..:|..:.
pombe  1102 RTSKDGLSLSLFKLL-SEKHPEAVTTLRLQYRMNEDINSLSSELIYGGNLVCGSKTISQKKLILP 1165

  Fly   867 EVELLNEAP------RWVQRALTTHLEQAVTLINTGDCLERCQEFVYASQRLVDTCSSIEQSFSE 925
            :..|.:..|      .||.:.:..  ..:|...||.|.|                  .:|
pombe  1166 KAHLSDGLPDSSSSLHWVNKLINP--SHSVIFFNTDDIL------------------GVE----- 1205

  Fly   926 DKDEIRKLTSKKRVSKYTNYCEAGIVMHLLRYLLKSGYEASRIGVIAPYRAQVELFKKLASKLDT 990
                      .|..:...|:.||.::...:...|:.|.:.|.||:|:.|::||||..| ..|..|
pombe  1206 ----------SKTNNILENHTEAFLIEQAVSSFLERGVKQSSIGIISIYKSQVELLSK-NLKSFT 1259

  Fly   991 DLECNTVDQFQGRDKNLIIYSCSKTGGDFSDMERSREAEILEDQRRLTVAITRAKNKLILLGDIK 1055
            ::|.||||::|||||::|:.|..::.      .::...|:|.|..||.||::|||.|.|:.|.:.
pombe  1260 EIEINTVDRYQGRDKDIILISFVRSN------SKNLVGELLRDWHRLNVALSRAKVKCIMFGSLS 1318

  Fly  1056 CLEQYGPFRQLFK 1068
            .|........|.|
pombe  1319 TLSSSNIVSHLLK 1331

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2990	NP_727386.1	Dna2	99..297	CDD:285859	57/290 (20%)
		Cas4_I-A_I-B_I-C_I-D_II-B	<283..415	CDD:294426	43/136 (32%)
		TIGR00376	480..1069	CDD:273041	200/637 (31%)
		P-loop_NTPase	636..859	CDD:304359	95/227 (42%)
		AAA_12	815..1055	CDD:289832	78/251 (31%)
dna2	NP_596499.2	Dna2	385..579	CDD:285859	49/204 (24%)
		DNA2	444..1352	CDD:224037	289/971 (30%)
		Cas4_I-A_I-B_I-C_I-D_II-B	<558..689	CDD:294426	48/145 (33%)
		P-loop_NTPase	932..>1096	CDD:304359	68/165 (41%)
		AAA_12	1118..1316	CDD:289832	73/239 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	95	1.000	Domainoid score	I1943
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6124
Inparanoid	1	1.050	342	1.000	Inparanoid score	I496
OMA	1	1.010	-	-		QHG56923
OrthoFinder	1	1.000	-	-		FOG0002978
OrthoInspector	1	1.000	-	-		oto100567
orthoMCL	1	0.900	-	-		OOG6_102643
Panther	1	1.100	-	-	LDO	PTHR10887
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R324
SonicParanoid	1	1.000	-	-		X1978
TreeFam	1	0.960	-	-
	14	13.860