DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG2990 and SETX

DIOPT Version :9

Sequence 1:NP_727386.1 Gene:CG2990 / 31934 FlyBaseID:FBgn0030170 Length:1100 Species:Drosophila melanogaster
Sequence 2:NP_001338457.1 Gene:SETX / 23064 HGNCID:445 Length:2706 Species:Homo sapiens


Alignment Length:1132 Identity:236/1132 - (20%)
Similarity:390/1132 - (34%) Gaps:412/1132 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   243 DPIVSFV--AQYVKGEPPSVLLPEVYRGQIHEICDIEENLWVPQLGLKGKVDVSVKVKNQRQREE 305
            ||....:  |...:|||.|....|            |:||::.|...: .:|:..:::|..    
Human  1469 DPTARHIEMAALKEGEPDSSSDAE------------EDNLFLTQNDPE-DMDLCSQMENDN---- 1516

  Fly   306 IIPLELKTGRASFSMEHKGQLLLYQLMHSAQGRDTQSGLLLYLKEGLLREVASGRNEQRDLLMLR 370
                                   |:|:....|:||.......:....|..::..:.:.:|.|...
Human  1517 -----------------------YKLIELIHGKDTVEVEEDSVSRPQLESLSGTKCKYKDCLETT 1558

  Fly   371 NDLAYWLTREVAIPASKEDPLEQLPLPEP----------VYHHSACGNCAYNTICSSFAQKDSSL 425
            .:...:..:...:.|:.||...:..||.|          ::...:....|.   .|...:..|:|
Human  1559 KNQGEYCPKHSEVKAADEDVFRKPGLPPPASKPLRPTTKIFSSKSTSRIAG---LSKSLETSSAL 1620

  Fly   426 QLSDSHPLKKL-----MPQLLEHLSEADHAYVQHWCGLLALEEQH--NRQSSHV-----RSFWTK 478
            ..|..:..|.:     :||.:..:::.....:::.|.:|..:..:  |||...|     :.|.:.
Human  1621 SPSLKNKSKGIQSILKVPQPVPLIAQKPVGEMKNSCNVLHPQSPNNSNRQGCKVPFGESKYFPSS 1685

  Fly   479 DPAE--REKEGIAIRHLKLVKGQEVILEEGRYRQTLELGEEADP-------SRDLSLSGFDLGEY 534
            .|..  ...:.::...:|     ||:  :.:|...|..|:...|       ||.:.:...:.|:|
Human  1686 SPVNILLSSQSVSDTFVK-----EVL--KWKYEMFLNFGQCGPPASLCQSISRPVPVRFHNYGDY 1743

  Fly   535 -------VVISSTSRLA-------------------VAAGFI------VSIEARRLDLRL---ER 564
                   :|:::...:|                   ..|.:|      |.:|...|..:|   |.
Human  1744 FNVFFPLMVLNTFETVAQEWLNSPNRENFYQLQVRKFPADYIKYWEFAVYLEECELAKQLYPKEN 1808

  Fly   565 DL----SQRYSEETFIIDKHDSQSFATF-----------------------------NF-TNLGM 595
            ||    .:|.:||....:::|.|....:                             || .||..
Human  1809 DLVFLAPERINEEKKDTERNDIQDLHEYHSGYVHKFRRTSVMRNGKTECYLSIQTQENFPANLNE 1873

  Fly   596 LLS-------------------EGERFQELRDIIVAKKPPEQHKVLPKIILTKGA----PILLNL 637
            |::                   .|.|.|..|.::    .|.......|.:||..:    ..|.:.
Human  1874 LVNCIVISSLVTTQRKLKAMSLLGSRNQLARAVL----NPNPMDFCTKDLLTTTSERIIAYLRDF 1934

  Fly   638 NKVQQNAALRALTTSSH-------LLIKGLPGTGKTQTLVALV-RLL---------------HLL 679
            |:.|:.|...|.....|       .||.|.|||||::|:|.|: |||               .:.
Human  1935 NEDQKKAIETAYAMVKHSPSVAKICLIHGPPGTGKSKTIVGLLYRLLTENQRKGHSDENSNAKIK 1999

  Fly   680 GKSVLITAQTHSAVDNLIMRLL------------PFG----LPMMRLGSGSRI------------ 716
            ...||:.|.:::|||.|:.:::            |.|    :.::|||....|            
Human  2000 QNRVLVCAPSNAAVDELMKKIILEFKEKCKDKKNPLGNCGDINLVRLGPEKSINSEVLKFSLDSQ 2064

  Fly   717 ----------------HK-------QLEEIS-----------------EERLTKDCKTVEEL--- 738
                            ||       ||:|:|                 :|.::|..|..:||   
Human  2065 VNHRMKKELPSHVQAMHKRKEFLDYQLDELSRQRALCRGGREIQRQELDENISKVSKERQELASK 2129

  Fly   739 -EKALGQPS-----------IVGVTCLGCGHPLFQ---RRQ----FDYCIVDEATQVLQPTVLRP 784
             ::..|:|.           |:..|....|..|.:   |.|    |...|||||.|..:...|.|
Human  2130 IKEVQGRPQKTQSIIILESHIICCTLSTSGGLLLESAFRGQGGVPFSCVIVDEAGQSCEIETLTP 2194

  Fly   785 LIH-CSKFVLVGDPEQLPPIVRSKEARQRGADETLFQR------------LDSEKATAVLSLQYR 836
            ||| |:|.:|||||:||||.|.|.:|::.|.|:::..|            :.|......|::|||
Human  2195 LIHRCNKLILVGDPKQLPPTVISMKAQEYGYDQSMMARFCRLLEENVEHNMISRLPILQLTVQYR 2259

  Fly   837 MNKTITRLANELTYGGDLK---------CASDEVSGARFEVELLNEAPRWVQRALTTHLEQAVTL 892
            |:..|....:...|..:||         |:||                 |.        .|...:
Human  2260 MHPDICLFPSNYVYNRNLKTNRQTEAIRCSSD-----------------WP--------FQPYLV 2299

  Fly   893 INTGDCLERCQEFVYASQRLVDTCSSIEQSFSEDKDEIRKLTSKKRVSKYTNYCEAGIVMHLLRY 957
            .:.||..||                       .|.|            .|.|..|..:||.:::.
Human  2300 FDVGDGSER-----------------------RDND------------SYINVQEIKLVMEIIKL 2329

  Fly   958 LLKSGYEAS--RIGVIAPYRAQVELFKKLASKLDTDL------ECNTVDQFQGRDKNLIIYSCSK 1014
            :.....:.|  .||:|..|:||..:.:|   .||.:.      |.:|||.||||.|:.:|.:|.:
Human  2330 IKDKRKDVSFRNIGIITHYKAQKTMIQK---DLDKEFDRKGPAEVDTVDAFQGRQKDCVIVTCVR 2391

  Fly  1015 TGGDFSDMERSREAEI--LEDQRRLTVAITRAKNKLILLGDIKCLEQ-----------YGPFRQL 1066
            .        .|.:..|  |...:||.|.|||||..|.:||.::.|.|           :.||   
Human  2392 A--------NSIQGSIGFLASLQRLNVTITRAKYSLFILGHLRTLMQLLPRSFCVHVNHSPF--- 2445

  Fly  1067 FKHIPDRCRLKLEEGRMEFGWQRIQED 1093
            |...|......|:|.:   .|.::.:|
Human  2446 FSPEPKYLHWALKENQ---HWNQLIQD 2469

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG2990NP_727386.1 Dna2 99..297 CDD:285859 13/55 (24%)
Cas4_I-A_I-B_I-C_I-D_II-B <283..415 CDD:294426 18/141 (13%)
TIGR00376 480..1069 CDD:273041 188/845 (22%)
P-loop_NTPase 636..859 CDD:304359 91/357 (25%)
AAA_12 815..1055 CDD:289832 63/270 (23%)
SETXNP_001338457.1 SEN1_N 37..>351 CDD:315409
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1158..1219
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1237..1258
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1351..1385
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1579..1604 3/24 (13%)
AAA_11 1933..2218 CDD:315699 75/284 (26%)
Bipartite nuclear localization signal. /evidence=ECO:0000255 2070..2087 2/16 (13%)
AAA_12 2225..2424 CDD:315700 62/269 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2503..2525
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2585..2606
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2626..2706
Necessary for nuclear localization 2690..2706
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165141443
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1112
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.740

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