DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2990 and DNA2

DIOPT Version :9

Sequence 1:	NP_727386.1	Gene:	CG2990 / 31934	FlyBaseID:	FBgn0030170	Length:	1100	Species:	Drosophila melanogaster
Sequence 2:	XP_006717743.1	Gene:	DNA2 / 1763	HGNCID:	2939	Length:	1090	Species:	Homo sapiens

Alignment Length:	1076	Identity:	346/1076 - (32%)
Similarity:	550/1076 - (51%)	Gaps:	149/1076 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 LIAAMDSISNHRLELTKWQRCE---VVRLEQLPNRKGLKVHVKRISGGDPETADCQLLPPWNCMP 115
            |:.|::::.|      |...||   |:...|....|.|                |.|...|..:|
Human    78 LVLAVNTVQN------KEGNCEKRLVITASQSLENKEL----------------CILRNDWCSVP 120

  Fly   116 MQVGDTVSLLGKWDPSAGCYVVDKEQGYCVSHPDFLISGTTVTGSLFCKRKSVLQERFRGLDSGN 180
            ::.||.:.|.|  |.::..:::||:.||.:.:||.|||||::..|:.|.|::||.|.||..|...
Human   121 VEPGDIIHLEG--DCTSDTWIIDKDFGYLILYPDMLISGTSIASSIRCMRRAVLSETFRSSDPAT 183

  Fly   181 SVMVIGTLVHELLQKVLRQKLFDKKHIQSALQEMLASSSLAHL--LYASNL----IQVEMEDHLM 239
            ..|:|||::||:.||.:......:|..:.|.|.:   ..:.||  :|..||    |:.|:||:|.
Human   184 RQMLIGTVLHEVFQKAINNSFAPEKLQELAFQTI---QEIRHLKEMYRLNLSQDEIKQEVEDYLP 245

  Fly   240 KFIDPIVSFVAQYVKGEPPSVLLP--------------EVYRGQIHEICDIEENLWVPQLGLKGK 290
            .|......|:.:....:.|.:.|.              ||.:..     ||||::|.|:.|||||
Human   246 SFCKWAGDFMHKNTSTDFPQMQLSLPSDNSKDNSTCNIEVVKPM-----DIEESIWSPRFGLKGK 305

  Fly   291 VDVSVKVKNQR---QREEIIPLELKTGRASFSMEHKGQLLLYQLMHSAQGRDTQSGLLLYLKEGL 352
            :||:|.||..|   .:.:|:|||||||:.|.|:||:.|::||.|:...:..|.::|||||||.|.
Human   306 IDVTVGVKIHRGYKTKYKIMPLELKTGKESNSIEHRSQVVLYTLLSQERRADPEAGLLLYLKTGQ 370

  Fly   353 LREVASGRNEQRDLLMLRNDLAYWLTREVAIPASKEDPLEQLPLPEPVYHHSACGNCAYNTICSS 417
            :..|.:...::|:||.|||.:|:.|...::..|::: ..:...||:.:.....|..|:....|:.
Human   371 MYPVPANHLDKRELLKLRNQMAFSLFHRISKSATRQ-KTQLASLPQIIEEEKTCKYCSQIGNCAL 434

  Fly   418 FAQKDSSLQLSDSHPLKKLMPQLLE---HLSEADHAYVQHWCGLLALEEQHNRQSSHVRSFWTKD 479
            :::.........|.|: .::|::.|   ||.:....|...||.:|.||.|......:.::.|...
Human   435 YSRAVEQQMDCSSVPI-VMLPKIEEETQHLKQTHLEYFSLWCLMLTLESQSKDNKKNHQNIWLMP 498

  Fly   480 PAEREKEG------IAIRHLKLVKGQEVILEEGRYRQTLELGEEADPSRDLSLSGFDLGEYVVIS 538
            .:|.||.|      |.:.|:|:|.       :|:|....:....|.|..:|.     .|:.|::|
Human   499 ASEMEKSGSCIGNLIRMEHVKIVC-------DGQYLHNFQCKHGAIPVTNLM-----AGDRVIVS 551

  Fly   539 STSR--LAVAAGFIVSIEARRLDLRLERDLSQRYSEETFIIDKHDSQSFATFNFTNLGMLLSEGE 601
            ...|  .|::.|::..|....:...|:|:||.......|.:|:.:..........||..|:....
Human   552 GEERSLFALSRGYVKEINMTTVTCLLDRNLSVLPESTLFRLDQEEKNCDIDTPLGNLSKLMENTF 616

  Fly   602 RFQELRDIIVAKKPPE----QHKVLPKIILTKGAPILLNLNKVQQNAALRALTTSSHLLIKGLPG 662
            ..::|||:|:..:.|:    ...|||.......|.||..|||.|:.|..:.|.:..:.||.|:||
Human   617 VSKKLRDLIIDFREPQFISYLSSVLPHDAKDTVACILKGLNKPQRQAMKKVLLSKDYTLIVGMPG 681

  Fly   663 TGKTQTLVALVRLLHLLGKSVLITAQTHSAVDNLIMRLLPFGLPMMRLGSGSRIHKQLEEISEER 727
            ||||.|:..|||:|:..|.|||:|:.|||||||::::|..|.:..:|||...::|..:::.:|:.
Human   682 TGKTTTICTLVRILYACGFSVLLTSYTHSAVDNILLKLAKFKIGFLRLGQIQKVHPAIQQFTEQE 746

  Fly   728 L--TKDCKTVEELEKALGQPSIVGVTCLGCGHPLFQRRQFDYCIVDEATQVLQPTVLRPLIHCSK 790
            :  :|..|::..||:......||..||:|..||:|.|:.||:||||||:|:.||..|.||....:
Human   747 ICRSKSIKSLALLEELYNSQLIVATTCMGINHPIFSRKIFDFCIVDEASQISQPICLGPLFFSRR 811

  Fly   791 FVLVGDPEQLPPIVRSKEARQRGADETLFQRLDSEKATAV-LSLQYRMNKTITRLANELTYGGDL 854
            ||||||.:||||:|.::|||..|..|:||:||:..|:..| |::|||||..|..|:|:|||.|.|
Human   812 FVLVGDHQQLPPLVLNREARALGMSESLFKRLEQNKSAVVQLTVQYRMNSKIMSLSNKLTYEGKL 876

  Fly   855 KCASDEVSGA----------RFEVEL---LNEAPRWVQRALTTHLEQAVTLINTGDCLERCQEFV 906
            :|.||:|:.|          :.|:|.   .::.| |:......:  ..|..:||.
Human   877 ECGSDKVANAVINLRHFKDVKLELEFYADYSDNP-WLMGVFEPN--NPVCFLNTD---------- 928

  Fly   907 YASQRLVDTCSSIEQSFSEDKDEIRKLTSKKRVSK--YTNYCEAGIVMHLLRYLLKSGYEASRIG 969
                                     |:.:.::|.|  .:|..||.:::.|....:|:|...|.||
Human   929 -------------------------KVPAPEQVEKGGVSNVTEAKLIVFLTSIFVKAGCSPSDIG 968

  Fly   970 VIAPYRAQVELFKKLASKLDTDLECNTVDQFQGRDKNLIIYSCSKTGGDFSDMERSREAEILEDQ 1034
            :|||||.|:::...|.::....:|.||||::|||||::::.|..::..|      ....|:|:|.
Human   969 IIAPYRQQLKIINDLLARSIGMVEVNTVDKYQGRDKSIVLVSFVRSNKD------GTVGELLKDW 1027

  Fly  1035 RRLTVAITRAKNKLILLGDIKCLEQYGPFRQLFKHI 1070
            |||.|||||||:||||||.:..|..|.|..:|..|:
Human  1028 RRLNVAITRAKHKLILLGCVPSLNCYPPLEKLLNHL 1063

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2990	NP_727386.1	Dna2	99..297	CDD:285859	70/217 (32%)
		Cas4_I-A_I-B_I-C_I-D_II-B	<283..415	CDD:294426	51/134 (38%)
		TIGR00376	480..1069	CDD:273041	208/618 (34%)
		P-loop_NTPase	636..859	CDD:304359	103/225 (46%)
		AAA_12	815..1055	CDD:289832	83/255 (33%)
DNA2	XP_006717743.1	Dna2	101..312	CDD:285859	73/236 (31%)
		Cas4_I-A_I-B_I-C_I-D_II-B	<291..427	CDD:294426	54/136 (40%)
		TIGR00376	501..1062	CDD:273041	208/616 (34%)
		P-loop_NTPase	655..905	CDD:304359	109/249 (44%)
		AAA_12	835..1047	CDD:289832	83/255 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	129	1.000	Domainoid score	I5291
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6124
Inparanoid	1	1.050	507	1.000	Inparanoid score	I1338
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56923
OrthoDB	1	1.010	-	-		D289214at33208
OrthoFinder	1	1.000	-	-		FOG0002978
OrthoInspector	1	1.000	-	-		oto88616
orthoMCL	1	0.900	-	-		OOG6_102643
Panther	1	1.100	-	-	LDO	PTHR10887
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R324
SonicParanoid	1	1.000	-	-		X1978
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.910