Protein Alignment Dna2 and dna-2

DIOPT Version :10

• Sequence 1: NP_727386.1
• Gene: Dna2 / 31934
• FlyBaseID: FBgn0288690
• Length: 1100
• Species: Drosophila melanogaster
• Sequence 2: NP_496516.1
• Gene: dna-2 / 174809
• WormBaseID: WBGene00001016
• Length: 1069
• Species: Caenorhabditis elegans
• Alignment Length: 1133
• Identity: 314/1133 - (27%)
• Similarity: 536/1133 - (47%)
• Gaps: 213/1133 - (18%)

  Fly    13 ENDNTDV--------TSSNPQKKFKEQLDFSSDEVENIDWGDNDDFDLALIAAMDSISNHRLELT 69
            |:|...|        |:|:|::|...:  ..|:.::..:..|:|.||..:|::
 Worm    29 EHDGDSVDSFENFCPTASSPKEKISPR--SRSERIQLQECDDDDSFDAPVISS------------ 79

  Fly    70 KWQRCEVVRLEQLPNRKGLK-----------VHV------KRISGGDPETADCQ-------LLPP 110
                    :...||...|:.           :|:      ||....|.|..|.:       |...
 Worm    80 --------KPPALPKDSGVSGFPCLFDDKNVIHLTARKGEKRDDCLDLECIDKEGTTRIVYLQDH 136

  Fly   111 WNCMPMQVGDTVSLLGKWDPSAGCYVVDKEQGYCVSHPDFLISGTTVTGSLFCKRKSVLQERFRG 175
            |:.|.::.|.|::|:|........::|:.:.|..:.:||.|:..|.|..:.||.||:||.::|:.
 Worm   137 WSEMSIEAGSTINLIGAQAWGDRDFLVNDDVGIVILNPDALVPCTAVASATFCARKTVLNDKFKF 201

  Fly   176 LDSGNSVMVIGTLVHELLQKVLR-----------QKLFDKKHIQSALQEMLASSSLAHLLYASNL 229
            .::.|..|::||::||:.|..:.           .|:::|:..:.| :|::|      |.:..:.
 Worm   202 GNASNKAMLLGTIMHEIFQTAITSKKRPVMENDLMKIWNKQAPKYA-EELVA------LSFTPSC 259

  Fly   230 IQVEMEDHLMKFIDPIVSFVAQYV------------KGEPPSVLLPEVYRGQIHEICDIEENLWV 282
            :..|::        |..|.:..::            |.||    ||.  :.::.|:.|||||:|.
 Worm   260 LDAELQ--------PYFSIICGWINKHYPLSNSFFSKREP----LPS--KSELLEVYDIEENIWD 310

  Fly   283 PQLGLKGKVDVSVKVKNQRQREEIIPLELKTGRASFSMEHKGQLLLYQLMHSAQ-GRDTQSGLLL 346
            .:||||||:||:::.|::...|.   ||||||::|.|.||.||:|||.:|.|:: .:....|.:|
 Worm   311 SKLGLKGKIDVTMRTKSRGGMES---LELKTGKSSCSSEHTGQVLLYCMMQSSRYEQPIGPGNIL 372

  Fly   347 YLKEGLLREVASGRNEQRDLLMLRNDLAYWLTREVAIPASKEDPLEQLPLPEPVYHHSACGNCAY 411
            |||:|....|.....:...:|..||.|:...          |||... .||:|......|..|.:
 Worm   373 YLKDGASHCVTPRAADLLGVLQQRNKLSVHF----------EDPTTS-NLPDPRQDSRFCDKCDH 426

  Fly   412 NTICSSFAQKDSSLQLSDSHPLKKLMPQLLEHLSEADHAYVQHWCGLLALEE--QHNRQSSHVRS 474
            .|:||.:.:.:.:...|:. .:|......:.||.:....|..:|...::.|.  :..|.:|..:.
 Worm   427 KTMCSFYQKTEENFSKSND-KMKNFAENEMAHLEQNHIEYAANWIRWISAEWKCERERMTSQNKD 490

  Fly   475 FWTKDPAEREKEGIAIRHL-----KLVKGQEVILEEGRYRQTLELGEEADPSRDLSLSGFDLGEY 534
            .|.|...||.:||..:..|     ::...|::|:...|    ..|.....|:       |..|:.
 Worm   491 LWLKSVQERVEEGTCLSDLHPVSEEMSNSQKIIISFSR----KFLKSSNTPT-------FRPGDV 544

  Fly   535 VVISSTSRLAVAAGFI--VSIEARRLDLRLERDLSQRYSEETFIIDKHDSQSFATFNFTNLGMLL 597
            .::|:...:|:....|  ||.:.:.:.:..::.:..|| |..|.:||:.|.|..:....||..||
 Worm   545 CLLSNKKHIAIGFALIDEVSDDQQIVKISTDKTIKSRY-EAPFHLDKYTSMSTHSTTLGNLVYLL 608

  Fly   598 SEGERFQELRDIIVAKKPP--------EQHKVLPKIILTKGAPILLNLNKVQQNAALRALTTSSH 654
            ...|..:.||:|:|...||        .....:.|||      |...||..|:.|.:.||.|...
 Worm   609 QNDEIGKRLRNILVDLLPPIIMDATGFNLTPAIKKII------IKAKLNNEQRKAVVHALATEDF 667

  Fly   655 LLIKGLPGTGKTQTLVALVRLLHLLGKSVLITAQTHSAVDNLIMRLLP--FGLPMMRLGSGSRIH 717
            ::::||||:|||..:..|::.|....|.||:.|.|||||||::.:|..  ....::||||.|.|.
 Worm   668 MMVEGLPGSGKTTLISVLIQCLVATNKKVLLAAFTHSAVDNILTKLTKEVAAEKILRLGSSSSIK 732

  Fly   718 KQLEEISEERLTKDCKTVEE----LEKALGQPSIVGVTCLGCGHP-----LFQRRQFDYCIVDEA 773
            ..:::::.:...:: :|.||    :.|.:....||..||    |.     ||..|.||..|||||
 Worm   733 DDIKKMTLKAKLEN-ETSEEYYAAVRKVMKTTPIVACTC----HHVPRELLFSYRHFDVVIVDEA 792

  Fly   774 TQVLQPTVLRPLIHCSKFVLVGDPEQLPPIVRSKEARQRGADETLFQRLDSEKATAVLSL--QYR 836
            :.||:|.:|..|...:|||||||.:||.|:|.|::|:|.||..:..::|.......|:||  |||
 Worm   793 SMVLEPLLLPVLATSNKFVLVGDCKQLTPLVVSRKAKQEGAGISTMEKLQQSHPGVVVSLTSQYR 857

  Fly   837 MNKTITRLANELTYGGDLKCASDEVSGARFE-----VELLNEAPRWVQRALTTHLEQAVTLINTG 896
            ||:.|:.|:::|.|...|.|.::.||.:..:     :..:::....:::||            :|
 Worm   858 MNREISVLSSKLFYENRLICGNESVSRSSLDRTGDYIVAMDDGSDHIRKAL------------SG 910

  Fly   897 DCLERCQEFVYASQRLVDTCSSIEQSFS-EDKDEIRKLTSKKRVSKYTNYCEAGIVMHLLRYLLK 960
            |..:.|.        .:||.|:|..... ||.:.          ....|..||.::..|.:..:.
 Worm   911 DIKDSCV--------FLDTQSTINSKMQCEDGEG----------GGMCNDGEAKLISELCQQFVM 957

  Fly   961 SGYEASRIGVIAPYRAQVELFKKLASKLDTD-LECNTVDQFQGRDKNLIIYSCSKTGGDFSDMER 1024
            ||.:...|||::.||.||:..:.:   |::| ||.||:|.:|||:|.:||:|.:.|...
 Worm   958 SGVKPHEIGVMSAYRRQVDHIRGI---LNSDELEVNTIDSYQGREKRVIIWSLTWTNNS------ 1013

  Fly  1025 SREAEILEDQRRLTVAITRAKNKLILLG 1052
            ::::|:|:|:||:.||:|||:.||:::|
 Worm  1014 TKKSELLKDERRVNVALTRARQKLVVVG 1041

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dna2	NP_727386.1	DNA2_N-like	153..378	CDD:411722	75/248 (30%)
		DEXXQc_DNA2	636..836	CDD:350799	79/212 (37%)
		AAA_12	815..1055	CDD:463780	69/247 (28%)
dna-2	NP_496516.1	Dna2	122..325	CDD:462565	58/223 (26%)
		Cas4	<300..430	CDD:441077	54/143 (38%)
		DNA2	<601..1060	CDD:440729	158/491 (32%)
		DEAD-like_helicase_N	650..857	CDD:475120	79/211 (37%)