Protein Alignment CG2990 and dna-2

DIOPT Version :9

• Sequence 1: NP_727386.1
• Gene: CG2990 / 31934
• FlyBaseID: FBgn0030170
• Length: 1100
• Species: Drosophila melanogaster
• Sequence 2: NP_496516.1
• Gene: dna-2 / 174809
• WormBaseID: WBGene00001016
• Length: 1069
• Species: Caenorhabditis elegans
• Alignment Length: 1136
• Identity: 314/1136 - (27%)
• Similarity: 536/1136 - (47%)
• Gaps: 219/1136 - (19%)

  Fly    13 ENDNTDV--------TSSNPQKKFKEQLDFSSDEVENIDWGDNDDFDLALIAAMDSISNHRLELT 69
            |:|...|        |:|:|::|...:  ..|:.::..:..|:|.||..:|::
 Worm    29 EHDGDSVDSFENFCPTASSPKEKISPR--SRSERIQLQECDDDDSFDAPVISS------------ 79

  Fly    70 KWQRCEVVRLEQLPNRKGLK-----------VHV------KRISGGDPETADCQ-------LLPP 110
                    :...||...|:.           :|:      ||....|.|..|.:       |...
 Worm    80 --------KPPALPKDSGVSGFPCLFDDKNVIHLTARKGEKRDDCLDLECIDKEGTTRIVYLQDH 136

  Fly   111 WNCMPMQVGDTVSLLGKWDPSAGCYVVDKEQGYCVSHPDFLISGTTVTGSLFCKRKSVLQERFRG 175
            |:.|.::.|.|::|:|........::|:.:.|..:.:||.|:..|.|..:.||.||:||.::|:.
 Worm   137 WSEMSIEAGSTINLIGAQAWGDRDFLVNDDVGIVILNPDALVPCTAVASATFCARKTVLNDKFKF 201

  Fly   176 LDSGNSVMVIGTLVHELLQKVLR-----------QKLFDKKHIQSALQEMLASSSLAHLLYASNL 229
            .::.|..|::||::||:.|..:.           .|:::|:..:.| :|::|      |.:..:.
 Worm   202 GNASNKAMLLGTIMHEIFQTAITSKKRPVMENDLMKIWNKQAPKYA-EELVA------LSFTPSC 259

  Fly   230 IQVEMEDHLMKFIDPIVSFVAQYV------------KGEPPSVLLPEVYRGQIHEICDIEENLWV 282
            :..|::        |..|.:..::            |.||    ||.  :.::.|:.|||||:|.
 Worm   260 LDAELQ--------PYFSIICGWINKHYPLSNSFFSKREP----LPS--KSELLEVYDIEENIWD 310

  Fly   283 PQLGLKGKVDVSVKVKNQRQREEIIPLELKTGRASFSMEHKGQLLLYQLMHSAQ-GRDTQSGLLL 346
            .:||||||:||:::.|::...|.   ||||||::|.|.||.||:|||.:|.|:: .:....|.:|
 Worm   311 SKLGLKGKIDVTMRTKSRGGMES---LELKTGKSSCSSEHTGQVLLYCMMQSSRYEQPIGPGNIL 372

  Fly   347 YLKEGLLREVASGRNEQRDLLMLRNDLAYWLTREVAIPASKEDPLEQLPLPEPVYHHSACGNCAY 411
            |||:|....|.....:...:|..||.|:...          |||... .||:|......|..|.:
 Worm   373 YLKDGASHCVTPRAADLLGVLQQRNKLSVHF----------EDPTTS-NLPDPRQDSRFCDKCDH 426

  Fly   412 NTICSSFAQKDSSLQLSDSHPLKKLMPQLLEHLSEADHAYVQHWCGLLALEE--QHNRQSSHVRS 474
            .|:||.:.:.:.:...|:. .:|......:.||.:....|..:|...::.|.  :..|.:|..:.
 Worm   427 KTMCSFYQKTEENFSKSND-KMKNFAENEMAHLEQNHIEYAANWIRWISAEWKCERERMTSQNKD 490

  Fly   475 FWTKDPAEREKEGIAIRHL-----KLVKGQEVILEEGRYRQTLELGEEADPSRDLSLSG---FDL 531
            .|.|...||.:||..:..|     ::...|::|:...|              :.|..|.   |..
 Worm   491 LWLKSVQERVEEGTCLSDLHPVSEEMSNSQKIIISFSR--------------KFLKSSNTPTFRP 541

  Fly   532 GEYVVISSTSRLAVAAGFI--VSIEARRLDLRLERDLSQRYSEETFIIDKHDSQSFATFNFTNLG 594
            |:..::|:...:|:....|  ||.:.:.:.:..::.:..|| |..|.:||:.|.|..:....||.
 Worm   542 GDVCLLSNKKHIAIGFALIDEVSDDQQIVKISTDKTIKSRY-EAPFHLDKYTSMSTHSTTLGNLV 605

  Fly   595 MLLSEGERFQELRDIIVAKKPP--------EQHKVLPKIILTKGAPILLNLNKVQQNAALRALTT 651
            .||...|..:.||:|:|...||        .....:.|||      |...||..|:.|.:.||.|
 Worm   606 YLLQNDEIGKRLRNILVDLLPPIIMDATGFNLTPAIKKII------IKAKLNNEQRKAVVHALAT 664

  Fly   652 SSHLLIKGLPGTGKTQTLVALVRLLHLLGKSVLITAQTHSAVDNLIMRLLP--FGLPMMRLGSGS 714
            ...::::||||:|||..:..|::.|....|.||:.|.|||||||::.:|..  ....::||||.|
 Worm   665 EDFMMVEGLPGSGKTTLISVLIQCLVATNKKVLLAAFTHSAVDNILTKLTKEVAAEKILRLGSSS 729

  Fly   715 RIHKQLEEISEERLTKDCKTVEE----LEKALGQPSIVGVTCLGCGHP-----LFQRRQFDYCIV 770
            .|...:::::.:...:: :|.||    :.|.:....||..||    |.     ||..|.||..||
 Worm   730 SIKDDIKKMTLKAKLEN-ETSEEYYAAVRKVMKTTPIVACTC----HHVPRELLFSYRHFDVVIV 789

  Fly   771 DEATQVLQPTVLRPLIHCSKFVLVGDPEQLPPIVRSKEARQRGADETLFQRLDSEKATAVLSL-- 833
            |||:.||:|.:|..|...:|||||||.:||.|:|.|::|:|.||..:..::|.......|:||
 Worm   790 DEASMVLEPLLLPVLATSNKFVLVGDCKQLTPLVVSRKAKQEGAGISTMEKLQQSHPGVVVSLTS 854

  Fly   834 QYRMNKTITRLANELTYGGDLKCASDEVSGARFE-----VELLNEAPRWVQRALTTHLEQAVTLI 893
            |||||:.|:.|:::|.|...|.|.::.||.:..:     :..:::....:::||
 Worm   855 QYRMNREISVLSSKLFYENRLICGNESVSRSSLDRTGDYIVAMDDGSDHIRKAL----------- 908

  Fly   894 NTGDCLERCQEFVYASQRLVDTCSSIEQSFS-EDKDEIRKLTSKKRVSKYTNYCEAGIVMHLLRY 957
             :||..:.|.        .:||.|:|..... ||.:.          ....|..||.::..|.:.
 Worm   909 -SGDIKDSCV--------FLDTQSTINSKMQCEDGEG----------GGMCNDGEAKLISELCQQ 954

  Fly   958 LLKSGYEASRIGVIAPYRAQVELFKKLASKLDTD-LECNTVDQFQGRDKNLIIYSCSKTGGDFSD 1021
            .:.||.:...|||::.||.||:..:.:   |::| ||.||:|.:|||:|.:||:|.:.|...
 Worm   955 FVMSGVKPHEIGVMSAYRRQVDHIRGI---LNSDELEVNTIDSYQGREKRVIIWSLTWTNNS--- 1013

  Fly  1022 MERSREAEILEDQRRLTVAITRAKNKLILLG 1052
               ::::|:|:|:||:.||:|||:.||:::|
 Worm  1014 ---TKKSELLKDERRVNVALTRARQKLVVVG 1041

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2990	NP_727386.1	Dna2	99..297	CDD:285859	60/227 (26%)
		Cas4_I-A_I-B_I-C_I-D_II-B	<283..415	CDD:294426	47/132 (36%)
		TIGR00376	480..1069	CDD:273041	183/611 (30%)
		P-loop_NTPase	636..859	CDD:304359	89/235 (38%)
		AAA_12	815..1055	CDD:289832	69/247 (28%)
dna-2	NP_496516.1	Dna2	122..325	CDD:285859	58/223 (26%)
		Cas4_I-A_I-B_I-C_I-D_II-B	<294..430	CDD:294426	54/151 (36%)
		TIGR00376	480..1062	CDD:273041	187/627 (30%)
		P-loop_NTPase	650..861	CDD:304359	83/215 (39%)
		AAA_12	834..1044	CDD:289832	69/247 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158970
Domainoid	1	1.000	99	1.000	Domainoid score	I4480
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6124
Inparanoid	1	1.050	363	1.000	Inparanoid score	I1270
Isobase	1	0.950	-	0	Normalized mean entropy	S2517
OMA	1	1.010	-	-		QHG56923
OrthoDB	1	1.010	-	-		D289214at33208
OrthoFinder	1	1.000	-	-		FOG0002978
OrthoInspector	1	1.000	-	-		oto17535
orthoMCL	1	0.900	-	-		OOG6_102643
Panther	1	1.100	-	-	LDO	PTHR10887
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R324
SonicParanoid	1	1.000	-	-		X1978
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.890