DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2990 and smg-2

DIOPT Version :9

Sequence 1:	NP_727386.1	Gene:	CG2990 / 31934	FlyBaseID:	FBgn0030170	Length:	1100	Species:	Drosophila melanogaster
Sequence 2:	NP_490829.1	Gene:	smg-2 / 171696	WormBaseID:	WBGene00004880	Length:	1069	Species:	Caenorhabditis elegans

Alignment Length:	718	Identity:	183/718 - (25%)
Similarity:	292/718 - (40%)	Gaps:	199/718 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   449 HAYVQHWCGLLALEEQHNRQSSHVRSFWTKDPAE------REKEG-----IAIRHL--------K 494
            |.|.:.:..|:|:|.:::|:        .|:.|.      |.::|     :|..||        |
Worm   272 HHYSKVFRPLVAIEAEYDRR--------VKESASQAVGTVRWEQGLRQSVLAFFHLPQFADGVMK 328

  Fly   495 LVKGQEVILEEGRYRQTLELGEEADPSRDLSLSGFDLGEYVVISSTSRLAVAAGFIVSIEARRLD 559
            |.||.|:.|   ::.||:                 |..|:..|.|..::....|..|.||
Worm   329 LAKGDELRL---KHSQTV-----------------DGSEWTKIGSVFKIPDNHGDEVGIE----- 368

  Fly   560 LRLERDLSQRYSEETFIIDKHDSQSFATFNFTNLGMLLSEGER-----FQELRDIIVAKKPPEQH 619
            :|...|.|...|...|.:|...:.:.....:..|..||::.:.     :|:|     ...|.|:.
Worm   369 IRGAVDKSVMESRIMFTVDVVWNATTFERQYKALAALLNDSKAISPYLYQKL-----LGHPAEEM 428

  Fly   620 KV---LPKIILTKGAPILLNLNKVQQNAALRALTTSSHLLIKGLPGTGKTQTLVALVRLLHLLGK 681
            .:   ||:.:...|.|   .||..|..|..:.||.... ||:|.|||||  |:|:...:.||:.|
Worm   429 MLKFDLPRRLSVAGLP---ELNSSQMQAVKQVLTRPLS-LIQGPPGTGK--TVVSATIVYHLVQK 487

  Fly   682 ---SVLITAQTHSAVDNLIMRLLPFGLPMMRLGSGSRIHK------------------------- 718
               :||:.:.::.|||:|..::...||.::||.:.||.|.
Worm   488 TEGNVLVCSPSNIAVDHLAEKIHKTGLKVVRLCARSREHSETTVPYLTLQHQLKVMGGAELQKLI 552

  Fly   719 QLEEISEERLTKD------CKTVEELEKALGQPSIVGVTCLGCGHPLFQRRQFDYCIVDEATQVL 777
            ||::.:.|...||      .|.|:|.| .|....::..||.........:.:....::||:||..
Worm   553 QLKDEAGELEFKDDLRYMQLKRVKEHE-LLAAADVICCTCSSAADARLSKIRTRTVLIDESTQAT 616

  Fly   778 QPTVLRPLIH-CSKFVLVGDPEQLPPIVRSKEARQRGADETLFQRLDSEKATAV--------LSL 833
            :|.:|..::. ..:.|||||..||.|:|..|:|...|..::||:||       |        |.:
Worm   617 EPEILVSIMRGVRQLVLVGDHCQLGPVVICKKAAIAGLSQSLFERL-------VLLGIRPFRLQV 674

  Fly   834 QYRMNKTITRLANELTYGGDLKCASDE----VSGARFEVELLNEAPRWVQRALTTHLEQAVTLIN 894
            ||||:..::...:.:.|.|.|:....|    ::|..:      ..|:..:.|...|
Worm   675 QYRMHPVLSEFPSNVFYDGSLQNGVTENDRHMTGVDW------HWPKPNKPAFFWH--------- 724

  Fly   895 TGDCLERCQEFVYASQRLVDTCSSIEQSFSEDKDEIRKLTSKKRVSKYTNYCEAGIVMHLLRYLL 959
                                 ||..|:..:..             :.:.|..||..|..|:..|:
Worm   725 ---------------------CSGSEELSASG-------------TSFLNRTEAANVEKLVSKLI 755

  Fly   960 KSGYEASRIGVIAPYRAQVELFKK-------LASKLDTDLECNTVDQFQGRDKNLIIYSCSKT-- 1015
            |:|.:..:||||.||..|......       |.|||..::|..:||.||||:|:.||.:|.::
Worm   756 KAGVQPHQIGVITPYEGQRSFIVNYMHTQGTLNSKLYENVEIASVDAFQGREKDYIIVTCVRSND 820

  Fly  1016 --GGDFSDMERSREAEILEDQRRLTVAITRAKNKLILLGDIKCLEQYGPFRQLFKHIPDRCRLKL 1078
              |..|           |.|.|||.|||||||..|:|:|:.|.|.::..:.:|..|.  :.:..|
Worm   821 ILGIGF-----------LSDPRRLNVAITRAKYGLVLVGNAKVLARHDLWHELINHY--KSKEML 872

  Fly  1079 EEG 1081
            .||
Worm   873 YEG 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2990	NP_727386.1	Dna2	99..297	CDD:285859
		Cas4_I-A_I-B_I-C_I-D_II-B	<283..415	CDD:294426
		TIGR00376	480..1069	CDD:273041	172/673 (26%)
		P-loop_NTPase	636..859	CDD:304359	75/265 (28%)
		AAA_12	815..1055	CDD:289832	68/262 (26%)
smg-2	NP_490829.1	UPF1_Zn_bind	93..243	CDD:286500
		DNA2	117..874	CDD:224037	181/715 (25%)
		AAA_19	452..>509	CDD:289986	22/59 (37%)
		AAA_12	654..851	CDD:289832	68/263 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810