DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2990 and ighmbp2

DIOPT Version :9

Sequence 1:	NP_727386.1	Gene:	CG2990 / 31934	FlyBaseID:	FBgn0030170	Length:	1100	Species:	Drosophila melanogaster
Sequence 2:	XP_004913487.1	Gene:	ighmbp2 / 100497063	XenbaseID:	XB-GENE-6258282	Length:	984	Species:	Xenopus tropicalis

Alignment Length:	696	Identity:	171/696 - (24%)
Similarity:	285/696 - (40%)	Gaps:	151/696 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   461 LEEQHNRQSSHVRSFWTKDPAEREKEGIAIRHLK-----LVKGQEVILEEGRYRQTLE--LGEEA 518
            |.|:...:....|: |        :|.|:::.|:     |:|.|......|.|.:.|.  ...:.
Frog    12 LREEREAEIQETRT-W--------RENISLKELQRRGVCLLKLQVANQRTGLYGRLLVTFTPRKY 67

  Fly   519 DPSRDLSLSGFDLGEYVVI--SSTSRLAVAAGFIVSIEARRLDLRLE---RDLSQRYSEETFIID 578
            |....|..:.|..|:.|.:  :|:....:|.|.:..:..:.:::..:   .|.....:|.|:.:.
Frog    68 DSEAILPSNSFGPGDIVGLYEASSPNEQLATGIVAGVTQKVVNVAFDESSNDSLNLGTECTYRLL 132

  Fly   579 KHDSQSFATFN-----FTNLGMLLSEGERFQELRDIIVAKKPPEQHKVLPKIILTKGAPILLNLN 638
            |..:.  .|:.     .|.||...| |:. ..|.|::.....| .|.|..:.:    ....|:|:
Frog   133 KLAND--VTYKRIKRALTALGQYRS-GQA-SSLIDVLFCSSEP-SHSVQKRQV----EFFNLSLD 188

  Fly   639 KVQQNAALRALTTSSHLLIKGLPGTGKTQTLVALVRLLHLLGKSVLITAQTHSAVDNLIMRLLPF 703
            ..|:.|...:|......:|.|.||||||.|:|.::......|..||..|.::.|||||:.||..|
Frog   189 DSQKEAVSFSLNQREVAVIHGPPGTGKTTTVVEIILQAVKEGLKVLCCAPSNVAVDNLVERLSVF 253

  Fly   704 GLPMMRLGSGSRI-----HKQLEEI-----------------------------SEER------- 727
            ...::|||..:|:     |..|:.:                             .:|:
Frog   254 KEKILRLGHPARLLESLQHHSLDAVLARSDNAQIVADIRRDIDQTFAKMKKLHGKQEKSGYRTEI 318

  Fly   728 --LTKDCKTVEE--LEKALGQPSIVGVTCLGCG----HPLFQRRQFDYCIVDEATQVLQPTVLRP 784
              |.|:.|..||  :.:.|.:.:::..|..|..    ..|.....||..::||..|.|:.:....
Frog   319 KALRKELKEREEAAMVETLKRANVILATNTGASLDGPLKLLPEDYFDLVVIDECAQALEASCWIS 383

  Fly   785 LIHCSKFVLVGDPEQLPPIVRSKEARQRGADETLFQRLD---SEKATAVLSLQYRMNKTITRLAN 846
            |:...|.:|.||.:||||.:.|.:|...|...:|.:|:.   .||...:|::||||:::|.:.|:
Frog   384 LLQAKKCILAGDHKQLPPTIISHKAAANGLSLSLMERVTEKYGEKVVKMLTVQYRMHQSIMQWAS 448

  Fly   847 ELTYGGDLKCASDEVSGARFEVELLNEAPRWVQRALTTHLEQAVTLINTGDCLERCQEFVYASQR 911
            |..|||.| .|...||     ..||.:.|     .::...|.::.|:
Frog   449 EALYGGRL-TAHSSVS-----QHLLKDLP-----GVSVTEETSIPLL------------------ 484

  Fly   912 LVDT--CSSIEQSFSEDKDEIRKLTSKKRVSKYTNYCEAGIVMHLLRYLLKSGYEASRIGVIAPY 974
            |:||  |...|.   |.:||..|          .|..|..:|...::.|.|:|.:...|.|||||
Frog   485 LIDTAHCGLFEM---EVEDEQSK----------GNPGEVQLVDLHIQALTKAGVKPQDIAVIAPY 536

  Fly   975 RAQVELFKKLASKLDTDLECNTVDQFQGRDKNLIIYSCSKTGGDFSDMERSREAEILEDQRRLTV 1039
            ..||::.::...:...|||..:||.||||:|..::.|       |.......|...|.:.||:.|
Frog   537 NLQVDMLRQCLRQRYPDLEIKSVDGFQGREKEAVVLS-------FVRSNSKGEVGFLAEDRRINV 594

  Fly  1040 AITRAKNKLILLGD-------------IKCLEQYGPFRQLFKHIPD 1072
            |:|||:..:.::.|             |....::|..|..|:::.|
Frog   595 AVTRARRHVAVICDSHTVGNHQFLKDLITYFSEHGEVRTAFEYLED 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2990	NP_727386.1	Dna2	99..297	CDD:285859
		Cas4_I-A_I-B_I-C_I-D_II-B	<283..415	CDD:294426
		TIGR00376	480..1069	CDD:273041	166/672 (25%)
		P-loop_NTPase	636..859	CDD:304359	77/274 (28%)
		AAA_12	815..1055	CDD:289832	69/257 (27%)
ighmbp2	XP_004913487.1	TIGR00376	20..636	CDD:273041	167/682 (24%)
		R3H_Smubp-2_like	714..773	CDD:100070
		zf-AN1	890..927	CDD:376545
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D289214at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920