DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG1889 and FGB

DIOPT Version :10

Sequence 1:NP_727376.2 Gene:CG1889 / 31928 FlyBaseID:FBgn0030164 Length:338 Species:Drosophila melanogaster
Sequence 2:NP_005132.2 Gene:FGB / 2244 HGNCID:3662 Length:491 Species:Homo sapiens


Alignment Length:406 Identity:108/406 - (26%)
Similarity:169/406 - (41%) Gaps:104/406 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 DLGGGLLVPPSLGNASSSSCPV-SAL----SGLTTRMQSLNNEIASVKEQIGS------------ 70
            |.||.|...|.||....:.|.: .||    ..:...:..|||.:.:|.:...|            
Human    91 DAGGCLHADPDLGVLCPTGCQLQEALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLW 155

  Fly    71 --LQEQLVDLRRAGSAPVVG----------LASPNALASRFPFSHNSL------------DIEPQ 111
              .|:|:.|     :..||.          |.....:.|..|.:...|            .:|..
Human   156 QKRQKQVKD-----NENVVNEYSSELEKHQLYIDETVNSNIPTNLRVLRSILENLRSKIQKLESD 215

  Fly   112 LLANGGAAAVPIT-----PANCLKQQHGVVR----------IRPRSNVEPFFVFCDQKVRNGGWT 161
            :.|.......|.|     |....|:...::|          |:|.|:|:|:.|:||....|||||
Human   216 VSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGWT 280

  Fly   162 MVVNRYDGSEDFNRKWADYKIGFGPLTT------------EFFIGLDKLHQITSSDNYELLVQLQ 214
            ::.||.|||.||.|||..||.|||.:.|            |:::|.||:.|:|.....|||::::
Human   281 VIQNRQDGSVDFGRKWDPYKQGFGNVATNTDGKNYCGLPGEYWLGNDKISQLTRMGPTELLIEME 345

  Fly   215 NRKQELRYALYDHFSIGSESEQYRLNVLGDYHGDAADALRD--------------HTGKKFSTHD 265
            :.|.:...|.|..|::.:|:.:|:::| ..|.|.|.:||.|              |.|..|||:|
Human   346 DWKGDKVKAHYGGFTVQNEANKYQISV-NKYRGTAGNALMDGASQLMGENRTMTIHNGMFFSTYD 409

  Fly   266 RVND-----ENEQNCAAQQSGAFWYGGSCNLTNPFGLYQ-------RLLERDVDGFKGILWRGFL 318
            |.||     :..:.|:.:..|.:|| ..|:..||.|.|.       .:.:...|  .|::|..: 
Human   410 RDNDGWLTSDPRKQCSKEDGGGWWY-NRCHAANPNGRYYWGGQYTWDMAKHGTD--DGVVWMNW- 470

  Fly   319 NGPKGSLKIVRMMVRP 334
            .|...|::.:.|.:||
Human   471 KGSWYSMRKMSMKIRP 486

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG1889NP_727376.2 FReD 123..335 CDD:238040 81/265 (31%)
FGBNP_005132.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 44..75
Beta-chain polymerization, binding distal domain of another fibrin 45..47
Fib_alpha 91..234 CDD:462570 28/147 (19%)
Fibrinogen_C 237..486 CDD:395095 77/253 (30%)
Blue background indicates that the domain is not in the aligned region.

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