Protein Alignment CG1889 and FCN1

DIOPT Version :10

• Sequence 1: NP_727376.2
• Gene: CG1889 / 31928
• FlyBaseID: FBgn0030164
• Length: 338
• Species: Drosophila melanogaster
• Sequence 2: NP_001994.2
• Gene: FCN1 / 2219
• HGNCID: 3623
• Length: 326
• Species: Homo sapiens
• Alignment Length: 220
• Identity: 81/220 - (36%)
• Similarity: 109/220 - (49%)
• Gaps: 19/220 - (8%)

  Fly   125 PANC---------LKQQHGVVRIRPRSNVEPFFVFCDQKVRNGGWTMVVNRYDGSEDFNRKWADY 180
            |.||         |...|.:.    ..:..|..|.||.....||||:...|.|||.||.|.||.|
Human   115 PRNCKDLLDRGYFLSGWHTIY----LPDCRPLTVLCDMDTDGGGWTVFQRRMDGSVDFYRDWAAY 175

  Fly   181 KIGFGPLTTEFFIGLDKLHQITSSDNYELLVQLQNRKQELRYALYDHFSIGSESEQYRLNVLGDY 245
            |.|||....||::|.|.:|.:|:..:.||.|.|.:.:...::|.|..|.:..|:|:|:| |||.:
Human   176 KQGFGSQLGEFWLGNDNIHALTAQGSSELRVDLVDFEGNHQFAKYKSFKVADEAEKYKL-VLGAF 239

  Fly   246 -HGDAADALRDHTGKKFSTHDRVNDENEQNCAAQQSGAFWYGGSCNLTNPFGLYQRLLERDVDGF 309
             .|.|.::|..|....|||.|:.||.:..|||.:..||:|| ..|:.:|..|||  |:.......
Human   240 VGGSAGNSLTGHNNNFFSTKDQDNDVSSSNCAEKFQGAWWY-ADCHASNLNGLY--LMGPHESYA 301

  Fly   310 KGILWRGFLNGPKGSLKIVRMMVRP 334
            .||.|.. ..|.|.|.|:..|.|||
Human   302 NGINWSA-AKGYKYSYKVSEMKVRP 325

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1889	NP_727376.2	FReD	123..335	CDD:238040	81/220 (37%)
FCN1	NP_001994.2	Collagen	52..107	CDD:460189
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	72..111
		FReD	115..325	CDD:238040	79/218 (36%)
		A domain, contributes to trimerization	115..154		9/42 (21%)
		B domain, contributes to trimerization	155..243		36/88 (41%)
		P domain. /evidence=ECO:0000303|PubMed:17148457	317..326		5/9 (56%)