DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1791 and ANGPTL1

DIOPT Version :9

Sequence 1:	NP_572591.1	Gene:	CG1791 / 31927	FlyBaseID:	FBgn0030163	Length:	334	Species:	Drosophila melanogaster
Sequence 2:	NP_001363692.1	Gene:	ANGPTL1 / 9068	HGNCID:	489	Length:	491	Species:	Homo sapiens

Alignment Length:	349	Identity:	104/349 - (29%)
Similarity:	163/349 - (46%)	Gaps:	80/349 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 LAGLAARVQFMTDELQNLKTELNELQ-----------------GLIEE-----YKNQGTGI--PI 94
            |:.|..::..:|.|:..:.|...||:                 .|:||     :..|.|.:  |:
Human   151 LSQLENKILNVTTEMLKMATRYRELEVKYASLTDLVNNQSVMITLLEEQCLRIFSRQDTHVSPPL 215

  Fly    95 ATRLLRPLPASVQ---------------TFPLALATPPD-------------------DTP-RNC 124
            ...:.:.:|.|.|               .:|..|..|||                   :.| ::|
Human   216 VQVVPQHIPNSQQYTPGLLGGNEIQRDPGYPRDLMPPPDLATSPTKSPFKIPPVTFINEGPFKDC 280

  Fly   125 YDEKH------GQVRIRIAPDMEPFFASCDQKVRDGGWMVIAYRFDGSEDFNKDWQNYKAGFGAL 183
            ...|.      |...|:......|....|:..:..|||.||..|.|||.:|.::|:|||.|||.:
Human   281 QQAKEAGHSVSGIYMIKPENSNGPMQLWCENSLDPGGWTVIQKRTDGSVNFFRNWENYKKGFGNI 345

  Fly   184 NSEFFIGLDKLHRLTNSEHHELLIIMKKKSGEERFALYDHFSIGSESEKYLLYVLGAYKGDAGDS 248
            :.|:::||:.::.|:|.::::|||.::..|.::.:|.|..|.:..|||.|.|. ||.|:|:||||
Human   346 DGEYWLGLENIYMLSNQDNYKLLIELEDWSDKKVYAEYSSFRLEPESEFYRLR-LGTYQGNAGDS 409

  Fly   249 LRYHAGKKFTTFDQDNDDNGQNCARTHAGAWWYGRECFESNLFGT------FQSKYGQEIGYFKG 307
            :.:|.||:|||.|:|.|....|||..|.|.||| ..|..|||.|.      ::||:..      |
Human   410 MMWHNGKQFTTLDRDKDMYAGNCAHFHKGGWWY-NACAHSNLNGVWYRGGHYRSKHQD------G 467

  Fly   308 ILWKSFLPGPTGSLSYVRMLIRPL 331
            |.|..: .|.:.||..|:|:|:|:
Human   468 IFWAEY-RGGSYSLRAVQMMIKPI 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1791	NP_572591.1	FReD	119..331	CDD:238040	82/224 (37%)
ANGPTL1	NP_001363692.1	PB1	74..138	CDD:383100
ANGPTL1	NP_001363692.1	FReD	275..490	CDD:238040	82/223 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40314
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X25
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.810