DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1791 and Tnxb

DIOPT Version :9

Sequence 1:	NP_572591.1	Gene:	CG1791 / 31927	FlyBaseID:	FBgn0030163	Length:	334	Species:	Drosophila melanogaster
Sequence 2:	XP_006525248.1	Gene:	Tnxb / 81877	MGIID:	1932137	Length:	4361	Species:	Mus musculus

Alignment Length:	368	Identity:	107/368 - (29%)
Similarity:	165/368 - (44%)	Gaps:	80/368 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LACLSTTTNATSNLPGKHFSVIMRNSAEPFLLAENDTASCPVSTLAGL-----------AARVQF 63
            |..|:..||.|:.:.|              |...|.|:...::...||           ..|...
Mouse  4017 LTDLALDTNYTATVRG--------------LRGPNFTSPASITFTTGLKPPQDLEAKEVTPRTAL 4067

  Fly    64 M---------TDELQNLKTELNELQGLIEEYKNQGTGIPIAT---RLLRPLPASVQTFPLAL--- 113
            :         |..|.:..|...::|.::         :|..|   ||||..|::..:..|..
Mouse  4068 LTWTEPEVPPTGYLLSFDTPGGQIQEIL---------LPAGTTSHRLLRLFPSTFYSAQLRAIWG 4123

  Fly   114 --ATPPDDT-----------PRNCYDE-KHG-----QVRIRIAPDME-PFFASCDQKVRDGGWMV 158
              .|||..|           ||:|.:| |:|     ...|.:..:.| |....||.:...|||:|
Mouse  4124 ESLTPPVLTSFTTGGLRIPFPRDCGEELKNGPSASKTTTIFLNGNRERPLDVFCDMETDGGGWLV 4188

  Fly   159 IAYRFDGSEDFNKDWQNYKAGFGALNSEFFIGLDKLHRLTNSEHHELLIIMKKKSGEER-FALYD 222
            ...|.||..||.:||:.|..|||.::.||::|.:.||.||.:..:.|.:.:  ::|:|. ||.||
Mouse  4189 FQRRMDGQTDFWRDWEEYAHGFGNISGEFWLGNEALHSLTQAGDYSLRVDL--RAGKEAVFAQYD 4251

  Fly   223 HFSIGSESEKYLLYVLGAYKGDAGDSLRYHAGKKFTTFDQDNDDNGQNCARTHAGAWWYGRECFE 287
            .|.:.|..|.|.|::.| |.|.||||:.||:|..|:..|:|.::...:||.::.||||| |.|..
Mouse  4252 FFRVDSAKENYRLHLEG-YHGTAGDSMSYHSGSVFSARDRDPNNLLISCAVSYRGAWWY-RNCHY 4314

  Fly   288 SNLFGTFQSKYGQEIGYFKGILWKSFLPGPTGSLSYVRMLIRP 330
            :||.|.    ||..:.: :|:.|..: .|...|:.:..|.:||
Mouse  4315 ANLNGL----YGSTVDH-QGVSWYHW-KGFEFSVPFTEMKLRP 4351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1791	NP_572591.1	FReD	119..331	CDD:238040	80/231 (35%)
Tnxb	XP_006525248.1	EGF_2	172..200	CDD:285248
		EGF_2	203..231	CDD:285248
		EGF_Tenascin	236..262	CDD:376143
		EGF_Tenascin	267..293	CDD:376143
		EGF_Tenascin	298..325	CDD:376143
		EGF_Tenascin	329..356	CDD:376143
		EGF_Tenascin	360..386	CDD:376143
		EGF_2	389..417	CDD:285248
		EGF_Tenascin	422..448	CDD:376143
		EGF_2	451..479	CDD:285248
		EGF_2	482..510	CDD:285248
		DSL	<498..541	CDD:366627
		EGF_2	541..572	CDD:285248
		EGF_Tenascin	577..604	CDD:376143
		EGF_2	608..634	CDD:285248
		EGF_Tenascin	639..665	CDD:376143
		EGF_Tenascin	706..732	CDD:376143
		fn3	737..818	CDD:365830
		fn3	830..906	CDD:365830
		fn3	1074..1142	CDD:365830
		fn3	1295..1369	CDD:365830
		FN3	1386..1466	CDD:238020
		fn3	1484..1558	CDD:365830
		fn3	1599..1674	CDD:365830
		fn3	1707..1782	CDD:365830
		fn3	1804..1874	CDD:365830
		fn3	1904..1971	CDD:365830
		fn3	2000..2067	CDD:365830
		fn3	2102..2164	CDD:365830
		FN3	2211..2279	CDD:238020
		fn3	2315..2393	CDD:365830
		fn3	2426..2496	CDD:365830
		fn3	2525..2600	CDD:365830
		fn3	2639..2709	CDD:365830
		fn3	2748..2823	CDD:365830
		fn3	2861..2931	CDD:365830
		fn3	2970..3043	CDD:365830
		fn3	3076..3146	CDD:365830
		fn3	3183..3258	CDD:365830
		fn3	3291..3361	CDD:365830
		fn3	3387..3462	CDD:365830
		fn3	3480..3542	CDD:365830
		fn3	3569..3649	CDD:365830
		fn3	3679..3752	CDD:365830
		fn3	3776..3855	CDD:365830
		fn3	3875..3953	CDD:365830
		FN3	3962..4048	CDD:238020	9/44 (20%)
		fn3	4052..4129	CDD:365830	14/85 (16%)
		Fibrinogen_C	4143..4352	CDD:278572	79/219 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910