DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1791 and TNR

DIOPT Version :9

Sequence 1:	NP_572591.1	Gene:	CG1791 / 31927	FlyBaseID:	FBgn0030163	Length:	334	Species:	Drosophila melanogaster
Sequence 2:	NP_003276.3	Gene:	TNR / 7143	HGNCID:	11953	Length:	1358	Species:	Homo sapiens

Alignment Length:	345	Identity:	105/345 - (30%)
Similarity:	161/345 - (46%)	Gaps:	51/345 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LPGKHFSVIMRNSAEPFLLAENDTASCPVSTL----AGLAARVQFMTDELQNLKTELNELQGLIE 83
            ||..|::..|..:..|.   .:.|.|...|||    |.|.|........|.:.:....|::..:.
Human  1012 LPSTHYTATMYATNGPL---TSGTISTNFSTLLDPPANLTASEVTRQSALISWQPPRAEIENYVL 1073

  Fly    84 EYKN------------QGTGIPIATRLLRP-----LPASVQTFPLALATPPDDT-------PRNC 124
            .||:            :.|.|.:...|...     |.|:..|...::.:....|       |::|
Human  1074 TYKSTDGSRKELIVDAEDTWIRLEGLLENTDYTVLLQAAQDTTWSSITSTAFTTGGRVFPHPQDC 1138

  Fly   125 Y------DEKHGQVRIRIAPDM-EPFFASCDQKVRDGGWMVIAYRFDGSEDFNKDWQNYKAGFGA 182
            .      |...|...|.:..:: :.....||.....|||:|...|.:|..||.:.|.:|:.|||.
Human  1139 AQHLMNGDTLSGVYPIFLNGELSQKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGN 1203

  Fly   183 LNSEFFIGLDKLHRLTNSEHHELLIIMKKKSGEE-RFALYDHFSIGSESEKYLLYVLGAYKGDAG 246
            :..||::|||.:||:|:...:||.:.|  :.|:| .||.||.||:......|.|.: |:|.|.||
Human  1204 VEDEFWLGLDNIHRITSQGRYELRVDM--RDGQEAAFASYDRFSVEDSRNLYKLRI-GSYNGTAG 1265

  Fly   247 DSLRYHAGKKFTTFDQDNDDNGQNCARTHAGAWWYGRECFESNLFGTF-QSKYGQEIGYFKGILW 310
            |||.||.|:.|:|.|:|||....|||.::.||||| :.|..:||.|.: :|::.|.|.::.   |
Human  1266 DSLSYHQGRPFSTEDRDNDVAVTNCAMSYKGAWWY-KNCHRTNLNGKYGESRHSQGINWYH---W 1326

  Fly   311 KSFLPGPTGSLSYVRMLIRP 330
            |    |...|:.:|.|.:||
Human  1327 K----GHEFSIPFVEMKMRP 1342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1791	NP_572591.1	FReD	119..331	CDD:238040	82/228 (36%)
TNR	NP_003276.3	EGF_2	<208..230	CDD:285248
		EGF_2	267..292	CDD:285248
		EGF_2	299..323	CDD:285248
		fn3	328..398	CDD:278470
		fn3	416..496	CDD:278470
		fn3	505..583	CDD:278470
		FN3	595..679	CDD:238020
		fn3	687..766	CDD:278470
		fn3	776..855	CDD:278470
		fn3	865..944	CDD:278470
		fn3	954..1026	CDD:278470	4/13 (31%)
		FN3	1042..1127	CDD:238020	13/84 (15%)
		FReD	1133..1342	CDD:238040	79/219 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19143
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910