DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1791 and Angptl3

DIOPT Version :9

Sequence 1:	NP_572591.1	Gene:	CG1791 / 31927	FlyBaseID:	FBgn0030163	Length:	334	Species:	Drosophila melanogaster
Sequence 2:	NP_038941.1	Gene:	Angptl3 / 30924	MGIID:	1353627	Length:	455	Species:	Mus musculus

Alignment Length:	376	Identity:	100/376 - (26%)
Similarity:	161/376 - (42%)	Gaps:	83/376 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 STTTNATSNLPGKHFSVIMRNSAEPFLLAENDTASCPVSTLAGLAARVQFMTDELQNL------- 71
            :|:|....|...|:.||.:.:..|..|  |..||         |..:|:.:.::|.||
Mouse   102 TTSTLQVKNEEVKNMSVELNSKLESLL--EEKTA---------LQHKVRALEEQLTNLILSPAGA 155

  Fly    72 -----KTELNE------------LQGLIEEYKN---------------QGTGI--PIATRLLRPL 102
                 .|.|..            ||.:.|:||.               :.|||  |....|....
Mouse   156 QEHPEVTSLKSFVEQQDNSIRELLQSVEEQYKQLSQQHMQIKEIEKQLRKTGIQEPSENSLSSKS 220

  Fly   103 PASVQTFPLAL----ATPPDDTPRNC---YDE-KHGQVRIRIAP-DMEPFFASCDQKVRDGG-WM 157
            .|...|.||.|    .|..||.|.:|   |:. :|......|.| :.:.|...||  .:.|. |.
Mouse   221 RAPRTTPPLQLNETENTEQDDLPADCSAVYNRGEHTSGVYTIKPRNSQGFNVYCD--TQSGSPWT 283

  Fly   158 VIAYRFDGSEDFNKDWQNYKAGFGALNSEFFIGLDKLHRLTNSEHHELLIIMKKKSGEERFALYD 222
            :|.:|.|||:|||:.|:||:.|||.|:.||::||:|::.:....::.|.:.::.....:.:..|.
Mouse   284 LIQHRKDGSQDFNETWENYEKGFGRLDGEFWLGLEKIYAIVQQSNYILRLELQDWKDSKHYVEYS 348

  Fly   223 HFSIGSESEKYLLYVLGAYKGDAGDSLRYHAGKKFTTFDQDNDDNGQ-NCARTHAGAWWYGRECF 286
             |.:||....|.|:| ....|:...:|..|....|:|:  ::...|| .|..:::|.||:...|.
Mouse   349 -FHLGSHETNYTLHV-AEIAGNIPGALPEHTDLMFSTW--NHRAKGQLYCPESYSGGWWWNDICG 409

  Fly   287 ESNLFGTF---QSKYGQEIGYFKGILWKSFLPGPTGSLSYV----RMLIRP 330
            |:||.|.:   ::|...|  ..:||.|:     |.....|.    :|:::|
Mouse   410 ENNLNGKYNKPRTKSRPE--RRRGIYWR-----PQSRKLYAIKSSKMMLQP 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1791	NP_572591.1	FReD	119..331	CDD:238040	65/226 (29%)
Angptl3	NP_038941.1	Sufficient to inhibit LIPG/EL phospholipase activity. /evidence=ECO:0000250\|UniProtKB:Q9Y5C1	17..207		23/115 (20%)
		Sufficient to inhibit LPL lipase activity. /evidence=ECO:0000250\|UniProtKB:Q9Y5C1, ECO:0000269\|PubMed:20581395	17..165		17/73 (23%)
		Required for inhibition of LPL lipase activity. /evidence=ECO:0000250\|UniProtKB:Q9Y5C1	32..56
		SPEC	<34..191	CDD:295325	23/99 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	202..242		12/39 (31%)
		FReD	241..453	CDD:238040	64/224 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900