DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1791 and FGG

DIOPT Version :9

Sequence 1:	NP_572591.1	Gene:	CG1791 / 31927	FlyBaseID:	FBgn0030163	Length:	334	Species:	Drosophila melanogaster
Sequence 2:	NP_068656.2	Gene:	FGG / 2266	HGNCID:	3694	Length:	453	Species:	Homo sapiens

Alignment Length:	278	Identity:	77/278 - (27%)
Similarity:	119/278 - (42%)	Gaps:	56/278 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 ELQNLKTELNELQGLIEEYKNQGTGIPIATRLLRPLPASVQTFPLALATPPDDTPRNCYD----- 126
            ::.|||.::.:|:...:|                |...:||..        |.|.::|.|
Human   146 KIVNLKEKVAQLEAQCQE----------------PCKDTVQIH--------DITGKDCQDIANKG 186

  Fly   127 -EKHGQVRIRIAPDMEPFFASCDQKVRDGGWMVIAYRFDGSEDFNKDWQNYKAGFGALN----SE 186
             ::.|...|:.....:.|...|:......||.|...|.|||.||.|:|..||.|||.|:    :|
Human   187 AKQSGLYFIKPLKANQQFLVYCEIDGSGNGWTVFQKRLDGSVDFKKNWIQYKEGFGHLSPTGTTE 251

  Fly   187 FFIGLDKLHRLTNSE--HHELLIIMKKKSGEERFALYDHFSIGSESEKYLL---YVLGAYKGDAG 246
            |::|.:|:|.::...  .:.|.:.::..:|....|.|..|.:|.|::||.|   |..|...|||.
Human   252 FWLGNEKIHLISTQSAIPYALRVELEDWNGRTSTADYAMFKVGPEADKYRLTYAYFAGGDAGDAF 316

  Fly   247 DSLRY-----------HAGKKFTTFDQDNDDNGQNCARTHAGAWWYGRECFESNLFGTF-----Q 295
            |...:           |.|.:|:|:|.|||....|||......||..: |...:|.|.:     .
Human   317 DGFDFGDDPSDKFFTSHNGMQFSTWDNDNDKFEGNCAEQDGSGWWMNK-CHAGHLNGVYYQGGTY 380

  Fly   296 SKYGQEIGYFKGILWKSF 313
            ||.....||..||:|.::
Human   381 SKASTPNGYDNGIIWATW 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1791	NP_572591.1	FReD	119..331	CDD:238040	68/226 (30%)
FGG	NP_068656.2	Fib_alpha	31..172	CDD:285864	8/41 (20%)
		FReD	175..414	CDD:294064	68/225 (30%)
		Gamma-chain polymerization, binding amino end of another fibrin alpha chain	400..422
		Platelet aggregation and Staphylococcus clumping	423..437
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	424..453
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X25
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810