DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1791 and Fgb

DIOPT Version :9

Sequence 1:	NP_572591.1	Gene:	CG1791 / 31927	FlyBaseID:	FBgn0030163	Length:	334	Species:	Drosophila melanogaster
Sequence 2:	NP_862897.1	Gene:	Fgb / 110135	MGIID:	99501	Length:	481	Species:	Mus musculus

Alignment Length:	395	Identity:	108/395 - (27%)
Similarity:	171/395 - (43%)	Gaps:	86/395 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 CLSTTTNATSNLPGKHFSVIMRNSAEPFLLAENDTASCP---VSTLAGLAARVQFMTDELQNLKT 73
            |....|......|.|.....:.|:.:    :.:||:|..   ::.|..:..:.|....|.:|:
Mouse   100 CTLQQTLLNQERPIKSSIAELNNNIQ----SVSDTSSVTFQYLTLLKDMWKKKQAQVKENENV-- 158

  Fly    74 ELNELQGLIEEYK-----NQGTGIPIATRLLR----PLPASVQTFPLALA-------TP------ 116
             :||...::|:.:     .....||:..|:||    .|.:.:|.....::       ||
Mouse   159 -INEYSSILEDQRLYIDETVNDNIPLNLRVLRSILEDLRSKIQKLESDISAQMEYCRTPCTVSCN 222

  Fly   117 -PDDTPRNCYD--EKHGQV--RIRIAPD--MEPFFASCDQKVRDGGWMVIAYRFDGSEDFNKDWQ 174
             |..:.:.|.:  .|.|:.  ...|.||  ::|:...||.|..:|||.||..|.|||.||.:.|.
Mouse   223 IPVVSGKECEEIIRKGGETSEMYLIQPDTSIKPYRVYCDMKTENGGWTVIQNRQDGSVDFGRKWD 287

  Fly   175 NYKAGFG------------ALNSEFFIGLDKLHRLTNSEHHELLIIMKKKSGEERFALYDHFSIG 227
            .||.|||            .|..|:::|.||:.:||.....||||.|:...|::..|.|..|::.
Mouse   288 PYKKGFGNIATNEDAKKYCGLPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQ 352

  Fly   228 SESEKYLLYVLGAYKGDAGDSL--------------RYHAGKKFTTFDQDND-----DNGQNCAR 273
            :|:.||.:.| ..|||.||::|              ..|.|..|:|:|:|||     |..:.|::
Mouse   353 NEASKYQVSV-NKYKGTAGNALMDGASQLVGENRTMTIHNGMFFSTYDRDNDGWVTTDPRKQCSK 416

  Fly   274 THAGAWWYGRECFESN---------LFGTFQSKYGQEIGYFKGILWKSFLPGPTGSLSYVRMLIR 329
            ...|.|||.| |..:|         |:....||:|.:    .|::|.:: .|...|:..:.|.||
Mouse   417 EDGGGWWYNR-CHAANPNGRYYWGGLYSWDMSKHGTD----DGVVWMNW-KGSWYSMRRMSMKIR 475

  Fly   330 PLKKQ 334
            |...|
Mouse   476 PFFPQ 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1791	NP_572591.1	FReD	119..331	CDD:238040	81/257 (32%)
Fgb	NP_862897.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..81
		Beta-chain polymerization, binding distal domain of another fibrin. /evidence=ECO:0000250	35..37
		Fib_alpha	82..224	CDD:285864	24/130 (18%)
		FReD	227..476	CDD:294064	80/255 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X25
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810