DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1791 and FGL2

DIOPT Version :9

Sequence 1:	NP_572591.1	Gene:	CG1791 / 31927	FlyBaseID:	FBgn0030163	Length:	334	Species:	Drosophila melanogaster
Sequence 2:	NP_006673.1	Gene:	FGL2 / 10875	HGNCID:	3696	Length:	439	Species:	Homo sapiens

Alignment Length:	371	Identity:	117/371 - (31%)
Similarity:	176/371 - (47%)	Gaps:	64/371 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LEALVTAL--ACLSTTTNATSN-LPGKHFSVIMRNSAEPFLLAENDTASCPVSTLAGLAARVQFM 64
            |:.:|.:|  :|......|..| .||:: .:::.::..|..:.:|        .:..|.:.|..:
Human    85 LKEIVNSLKKSCQDCKLQADDNGDPGRN-GLLLPSTGAPGEVGDN--------RVRELESEVNKL 140

  Fly    65 TDELQNLKTELNELQGLIEEYK------------NQGTGIPIATRLLR------PLPASVQTFPL 111
            :.||:|.|.|:|.|.|.:|:..            ::...:......|.      |....:|:.|:
Human   141 SSELKNAKEEINVLHGRLEKLNLVNMNNIENYVDSKVANLTFVVNSLDGKCSKCPSQEQIQSRPV 205

  Fly   112 ALATPPDDTPRNCYD----EKHGQVRIRIAPDME--PFFASCDQKVRDGGWMVIAYRFDGSEDFN 170
            ......|     |.|    .|......|:.||.:  .|...||.:...|||.|:..|.|||.:|.
Human   206 QHLIYKD-----CSDYYAIGKRSSETYRVTPDPKNSSFEVYCDMETMGGGWTVLQARLDGSTNFT 265

  Fly   171 KDWQNYKAGFGALNSEFFIGLDKLHRLTNSEHHELLIIMKKKSGEERFALYDHFSIGSESEKYLL 235
            :.||:||||||.|..||::|.||:|.||.|:...|.|.::..:|.|.:||||.|.:.:|..||.|
Human   266 RTWQDYKAGFGNLRREFWLGNDKIHLLTKSKEMILRIDLEDFNGVELYALYDQFYVANEFLKYRL 330

  Fly   236 YVLGAYKGDAGDSLRY-----HAGKKFTTFDQDND--DNGQNCARTHAGAWWYGRECFESNLFGT 293
            :| |.|.|.|||:||:     |..|.|||.|:|||  .:| ||...::..||:. .|..:||.|.
Human   331 HV-GNYNGTAGDALRFNKHYNHDLKFFTTPDKDNDRYPSG-NCGLYYSSGWWFD-ACLSANLNGK 392

  Fly   294 FQSKYGQEI-GYFKGILWKSFLPG-----PTG---SLSYVRMLIRP 330
            :   |.|:. |...||.|.:: ||     |.|   |....:|:|||
Human   393 Y---YHQKYRGVRNGIFWGTW-PGVSEAHPGGYKSSFKEAKMMIRP 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1791	NP_572591.1	FReD	119..331	CDD:238040	91/234 (39%)
FGL2	NP_006673.1	DUF460	<28..>161	CDD:331991	21/84 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	103..126		5/23 (22%)
		FReD	209..435	CDD:294064	92/238 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X25
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810