DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1986 and Lpl

DIOPT Version :9

Sequence 1:	NP_001285067.1	Gene:	CG1986 / 31925	FlyBaseID:	FBgn0030162	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_036730.1	Gene:	Lpl / 24539	RGDID:	3017	Length:	474	Species:	Rattus norvegicus

Alignment Length:	322	Identity:	110/322 - (34%)
Similarity:	141/322 - (43%)	Gaps:	64/322 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 LRNSLERAHLNHGIVFECRTISAKDFGNEVHFNLQLGDLRGFRRLDPNKKLALFLHGWNDQGS-K 108
            |.:|:...|.||         |:|.|                          :.:|||...|. :
  Rat    60 LADSVSNCHFNH---------SSKTF--------------------------VVIHGWTVTGMYE 89

  Fly   109 DWVQELLLTWTLFDSNYNVCVVDWGNLSQNDYKSASMSIFDVGLTVAGIIMALEELRPNHFHRSN 173
            .||.:|:......:.:.||.||||...:|..|..::.....||..||..|..|||  ..::...|
  Rat    90 SWVPKLVAALYKREPDSNVIVVDWLYRAQQHYPVSAGYTKLVGNDVARFINWLEE--EFNYPLDN 152

  Fly   174 VTLAGYSLGAHAAGYAGAVLEGQVEQIIGLDPAGPLFSLPAEVAPKYRLDPGDAQFVQVLHT--- 235
            |.|.||||||||||.||::...:|.:|.|||||||.|.. || ||. ||.|.||.||.||||
  Rat   153 VHLLGYSLGAHAAGVAGSLTNKKVNRITGLDPAGPNFEY-AE-APS-RLSPDDADFVDVLHTFTR 214

  Fly   236 --SGGSLGTSLKCGHADFYPNGGRAPQTNCKMFANLR--------DMQNTNPVSCSHSAAA-IFF 289
              .|.|:|.....||.|.|||||.. |..|.:...:|        |:...  |.|||..:. :|.
  Rat   215 GSPGRSIGIQKPVGHVDIYPNGGTF-QPGCNIGEAIRVIAEKGLGDVDQL--VKCSHERSIHLFI 276

  Fly   290 RQSMDPEYPFVGYECGSYREFAAGYCDGNRKAR-----FGIHSQRRAQGS-FYFRTAPQQPY 345
            ...::.|.|...|.|.|...|..|.|...||.|     :.|:..|..:.| .|.:|..|.||
  Rat   277 DSLLNEENPSKAYRCNSKEAFEKGLCLSCRKNRCNNVGYEINKVRAKRSSKMYLKTRSQMPY 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1986	NP_001285067.1	Pancreat_lipase_like	67..341	CDD:238363	101/294 (34%)
Lpl	NP_036730.1	Interaction with GPIHBP1. /evidence=ECO:0000250\|UniProtKB:P06858	32..53
		lipo_lipase	33..472	CDD:132274	110/322 (34%)
		Pancreat_lipase_like	37..334	CDD:238363	107/316 (34%)
		Essential for determining substrate specificity. /evidence=ECO:0000250\|UniProtKB:P06858	243..266		4/24 (17%)
		PLAT_LPL	341..465	CDD:238856
		Important for interaction with lipoprotein particles. /evidence=ECO:0000250\|UniProtKB:P06858	417..421
		Important for heparin binding. /evidence=ECO:0000250\|UniProtKB:P06858	430..434
		Interaction with GPIHBP1. /evidence=ECO:0000250\|UniProtKB:P06858	443..467
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010