DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1986 and Lpl

DIOPT Version :9

Sequence 1:	NP_001285067.1	Gene:	CG1986 / 31925	FlyBaseID:	FBgn0030162	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_032535.2	Gene:	Lpl / 16956	MGIID:	96820	Length:	474	Species:	Mus musculus

Alignment Length:	365	Identity:	120/365 - (32%)
Similarity:	161/365 - (44%)	Gaps:	61/365 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLLLG----CLLCLLGDVPRIEAFHRWSPMMKAF--RYLQETMLRNSLERAHLNHGIVFECRTIS 66
            |::||    .|....|.|...:|...:|.:...|  |..::|    :.:..||..|:.
Mouse     8 LVVLGVWLQSLTAFRGGVAAADAGRDFSDIESKFALRTPEDT----AEDTCHLIPGLA------- 61

  Fly    67 AKDFGNEVHFNLQLGDLRGFRRLDPNKKLALFLHGWNDQGS-KDWVQELLLTWTLFDSNYNVCVV 130
              |..:..|||             .:.|..:.:|||...|. :.||.:|:......:.:.||.||
Mouse    62 --DSVSNCHFN-------------HSSKTFVVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVV 111

  Fly   131 DWGNLSQNDYKSASMSIFDVGLTVAGIIMALEELRPNHFHRSNVTLAGYSLGAHAAGYAGAVLEG 195
            ||...:|..|..::.....||..||..|..:||  ..::...||.|.||||||||||.||::...
Mouse   112 DWLYRAQQHYPVSAGYTKLVGNDVARFINWMEE--EFNYPLDNVHLLGYSLGAHAAGVAGSLTNK 174

  Fly   196 QVEQIIGLDPAGPLFSLPAEVAPKYRLDPGDAQFVQVLHT-----SGGSLGTSLKCGHADFYPNG 255
            :|.:|.|||||||.|.. || ||. ||.|.||.||.||||     .|.|:|.....||.|.||||
Mouse   175 KVNRITGLDPAGPNFEY-AE-APS-RLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNG 236

  Fly   256 GRAPQTNCKMFANLR--------DMQNTNPVSCSHSAAA-IFFRQSMDPEYPFVGYECGSYREFA 311
            |.. |..|.:...:|        |:...  |.|||..:. :|....::.|.|...|.|.|...|.
Mouse   237 GTF-QPGCNIGEAIRVIAERGLGDVDQL--VKCSHERSIHLFIDSLLNEENPSKAYRCNSKEAFE 298

  Fly   312 AGYCDGNRKAR-----FGIHSQRRAQGS-FYFRTAPQQPY 345
            .|.|...||.|     :.|:..|..:.| .|.:|..|.||
Mouse   299 KGLCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRSQMPY 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1986	NP_001285067.1	Pancreat_lipase_like	67..341	CDD:238363	103/294 (35%)
Lpl	NP_032535.2	Interaction with GPIHBP1. /evidence=ECO:0000250\|UniProtKB:P06858	32..53		4/24 (17%)
		lipo_lipase	33..472	CDD:132274	113/340 (33%)
		Pancreat_lipase_like	37..334	CDD:238363	109/330 (33%)
		Essential for determining substrate specificity. /evidence=ECO:0000250\|UniProtKB:P06858	243..266		4/24 (17%)
		PLAT_LPL	341..465	CDD:238856
		Important for interaction with lipoprotein particles. /evidence=ECO:0000250\|UniProtKB:P06858	417..421
		Important for heparin binding. /evidence=ECO:0000250\|UniProtKB:P06858	430..434
		Interaction with GPIHBP1. /evidence=ECO:0000250\|UniProtKB:P06858	443..467
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010