Protein Alignment HNRNPU and CG30122

DIOPT Version :10

• Sequence 1: NP_114032.2
• Gene: HNRNPU / 3192
• HGNCID: 5048
• Length: 825
• Species: Homo sapiens
• Sequence 2: NP_001163196.1
• Gene: CG30122 / 37146
• FlyBaseID: FBgn0050122
• Length: 1272
• Species: Drosophila melanogaster
• Alignment Length: 1086
• Identity: 275/1086 - (25%)
• Similarity: 433/1086 - (39%)
• Gaps: 315/1086 - (29%)

Human     8 VKKLKVSELKEELKKRRLSDKGLKAELMERLQA-----ALDDEEAGGRPAMEPGNGSLDLGGDSA 67
            ::|:||.:|:.||:.|.|..||:||.|:|||:|     |.|.|.|...|:.......      |.
  Fly     6 LEKMKVVDLRNELQSRGLDTKGVKAVLVERLRAYVEGGAGDGENAPVTPSRRQRRTR------SM 64

Human    68 GRSGAGLEQEAAAGGD-----EEEEE---------EEEEEEGISALDGDQMELGEENGAAGAADS 118
            .||.:.::....|...     ||||:         |.|.|:..:..:.:|.|..|...||...:.
  Fly    65 SRSPSPVQAAPVAAEPVLDTLEEEEQPEDKTVPQPEPESEQPAAEPEPEQSEPEEAEPAAAVTED 129

Human   119 GPMEE---EEAASEDENGDDQG--------FQEG------EDELGDEEEGAGDENGHGEQQPQPP 166
            ..:.:   ||:..|.|..|::.        .:|.      ::|:.||......:....||:|
  Fly   130 TTVNQAVNEESQPEPEEFDEKSETDDKQETIEEAVPAVVPQNEVADEPMEEDHDAAPEEQEP--- 191

Human   167 ATQQQQPQQQRGAAKEAA-GKSSGPTSLFAVTVAPPGARQGQQQAGGKKKAEGGGGGGRP-GAPA 229
             ||.::|.:::.|....| .:|:|.:....|         .::.:...|.||......:| ..|.
  Fly   192 -TQTEEPVEEKPAESTVAEHQSNGDSQKMDV---------DEEDSAAPKTAEETEPAAKPEDQPP 246

Human   230 AGDGKTEQKGGDKKRGVKRPREDHGRGYFEYIEENKYSRAKSPQPPVEEEDEHFDDTVVCLDTYN 294
            ....::..:...:.|...|..:..|.     :.:.:.|:|.:.:..|.|::...::..|.|...:
  Fly   247 ERRKRSHSRSKSRSRSGSRSSKHRGS-----VGDKRESKAAAEERTVPEDEPTIEENKVGLSWLD 306

Human   295 CDLHFKISRDRL-SASSLTMESFAFLWAGGRASYGVSKGKVCFEMKVTEK-IPVR-HLYTKDIDI 356
            .|||.:|..... ||..||.|.::.:|:|.||:|||.:||||||::::|: :|.. |.:..:..:
  Fly   307 SDLHLRIDPTTFASAKPLTSEIYSLIWSGARANYGVREGKVCFEVRLSEESVPENSHYFRDEPHV 371

Human   357 HEVRIGWSLTTSGMLLGEEEFSYGYSLKGIKTCNCETEDYGEKFDENDVITCFANFESDEVELSY 421
            ...|:|:|:..|.:||||.|.|:||...|.|....|..|||:.:..:|||.|:.:.||:...::|
  Fly   372 RGFRVGFSMPKSSLLLGEAEHSFGYCETGRKATQSEFTDYGKPYQLDDVIGCYLDLESEPCTINY 436

Human   422 AKNGQDLGVAFKISKEVLAGR-PLFPHVLCHNCAVEFNF-------------------------- 459
            ..||:||||||:..|.:|... .||||::........||
  Fly   437 TLNGEDLGVAFEFEKSILGEEGALFPHIVTKGYEYLVNFSDTEQLLVNAERPTRKRRKPRKDEDK 501

Human   460 ----------GQK---------------------------------------------------- 462
                      |:|
  Fly   502 DKDDDKDDNDGEKWKVLDEATADDDEVEKKDEDGKASSEKDEEEAEDPEKAKEDEAAPKTETEAE 566

Human   463 ------------------------------------------------------EKP-------- 465
                                                                  :||
  Fly   567 TKVEAPAEAAKPESEATEASETAETSTEKSSETAAVSNGDAAAEQANDEKASEDKKPSENNDEED 631

Human   466 -------------------------------------YFPIP-------EEYTFIQNVPLEDRVR 486
                                                 ..|.|       |.|..|..||:|..|.
  Fly   632 EDGPSPNKRPKTDGDSEKAESEKEKDRSQTTEDEYEDVVPEPRDTAALLEGYVLIGLVPVEKLVS 696

Human   487 GPKGPEEKKDCEVVMMIGLPGAGKTTWVTKHAAENPGK-YNILGTNTIMDKMMVAGFKKQMADTG 550
            ||:....:|:|||::::||||||||.|..||.|||..| |.::|.:..:.||.:.|..::....|
  Fly   697 GPQRVGSRKECEVILLVGLPGAGKTHWAHKHVAENADKRYELIGPDAFISKMTIDGASRKTVHKG 761

Human   551 KLNTLLQRAPQCLGKFIEIAARKKRNFILDQTNVSAAAQRRKMCLFAGFQRKAVVVCPKDEDYKQ 615
            :.:.:.:.....|....:||.:::||||||||||.|:||||||..|..|:|.|||..|.:::.|:
  Fly   762 RWDKVYEICLNSLAALEDIAMKRRRNFILDQTNVYASAQRRKMKGFNDFKRIAVVCIPSEDELKR 826

Human   616 RTQKKAEVEGK--DLPEHAVLKMKGNFTLPEVA-ECFDEITYVELQKEEAQKLLEQYKEESKKAL 677
            |..:|.| :|.  .:.|..:..::.|||||.:. ..||:|.|.||..:||:..:::|.|:.|||:
  Fly   827 RIAEKEE-KGNAFTVKESTINNLRANFTLPSLEFGWFDDINYTELTGDEAKSEVKKYNEKGKKAI 890

Human   678 PPEKKQNTGSKKSNKN----KSGKNQFN--------------------RGGGHRGRGGFNMRGGN 718
            ..|:.::..|:.|..|    ...:|::|                    |||   |.||::...|.
  Fly   891 DAERSRDKRSRGSRDNYRRDDRNRNRYNDDRRRDYGGQRHESRWSDSRRGG---GGGGYSSNSGG 952

Human   719 FRGGAPG--NRGGYN-------------RRGNMPQRGGGGGGSGGIGYPYPRAPVFPGRGSYSNR 768
              ||:.|  ||..||             ||.....||.||||||..||.........|.|.....
  Fly   953 --GGSRGYDNRRNYNSGSGGQQNWVQNSRRSGYDDRGYGGGGSGSRGYDNRNRGYAGGSGGGGGG 1015

Human   769 GNYNRGG------MPNRGNYNQNFRGRGNNRGYKNQSQGYNQWQQG 808
            |....||      |.|......:.||.|::|.|:::.:|.::.:.|
  Fly  1016 GGGGGGGGGQQNWMQNNRRSGYDDRGYGSSRDYRDRDRGNDRSRMG 1061

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HNRNPU	NP_114032.2	SAP	8..42	CDD:128789	17/38 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	41..281		53/272 (19%)
		SPRY_hnRNP	288..463	CDD:293942	70/320 (22%)
		ATPase domain. /evidence=ECO:0000269|PubMed:28622508	488..672		73/187 (39%)
		AAA_33	499..643	CDD:463952	58/146 (40%)
		Actin-binding. /evidence=ECO:0000269|PubMed:15711563	611..626		4/14 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	671..749		34/116 (29%)
		RNA-binding RGG-box. /evidence=ECO:0000269|PubMed:14608463, ECO:0000269|PubMed:1628625	714..739		10/39 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	769..799		10/35 (29%)
CG30122	NP_001163196.1	SAP	6..40	CDD:460424	17/33 (52%)
		PLN03124	8..>168	CDD:215591	44/165 (27%)
		SPRY_hnRNP	300..480	CDD:293942	68/179 (38%)
		PTZ00121	<520..>677	CDD:173412	4/156 (3%)
		AAA_33	709..855	CDD:463952	58/146 (40%)
		SF-CC1	1036..>1108	CDD:273721	7/26 (27%)