DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ser7 and TMPRSS5

DIOPT Version :9

Sequence 1:	NP_572582.1	Gene:	Ser7 / 31917	FlyBaseID:	FBgn0019929	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_110397.2	Gene:	TMPRSS5 / 80975	HGNCID:	14908	Length:	457	Species:	Homo sapiens

Alignment Length:	288	Identity:	91/288 - (31%)
Similarity:	126/288 - (43%)	Gaps:	65/288 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 CGS-AFSFRLVGGHNTGLFEFPWTTLLEYETVSGGKDYACGASFIAQRWLLTAAHCIHTMGRNLT 187
            ||: ..:.|:|||.:.....:||..     :|:.|..:.||.|.:|.||::|||||:|    :..
Human   209 CGARPLASRIVGGQSVAPGRWPWQA-----SVALGFRHTCGGSVLAPRWVVTAAHCMH----SFR 264

  Fly   188 AAILGEWNRDTDPDCENDLNGV--RECAPPHIRVTIDRILPHAQYSELNYRNDIALLRLSRPVNW 250
            .|.|..|....         |:  .....||....::||:||..||..|:..|:|||||...:|:
Human   265 LARLSSWRVHA---------GLVSHSAVRPHQGALVERIIPHPLYSAQNHDYDVALLRLQTALNF 320

  Fly   251 LQMQNLEPVCLPPQRGRYANQLAGSAADVSGWGKTESSGSSKIKQKAMLHIQPQDQCQEAFYKDT 315
              ...:..||||.:...:..   ||...|||||.|..|           |....|..|     ||
Human   321 --SDTVGAVCLPAKEQHFPK---GSRCWVSGWGHTHPS-----------HTYSSDMLQ-----DT 364

  Fly   316 KITLADSQ----------------MCAGGEIG-VDSCSGDSGGPLTVEANTASGNRYVYLAGVVS 363
            .:.|..:|                :|||...| .|:|.|||||||.    ...|:.: .|.||||
Human   365 VVPLFSTQLCNSSCVYSGALTPRMLCAGYLDGRADACQGDSGGPLV----CPDGDTW-RLVGVVS 424

  Fly   364 IGRKHCGTALFSGIYTRVSSYMDWIEST 391
            .|| .|......|:|.:|:.::|||..|
Human   425 WGR-GCAEPNHPGVYAKVAEFLDWIHDT 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser7	NP_572582.1	CLIP	29..74	CDD:197829
		Tryp_SPc	131..388	CDD:214473	86/275 (31%)
		Tryp_SPc	133..391	CDD:238113	87/276 (32%)
TMPRSS5	NP_110397.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		SRCR_2	116..213	CDD:292133	2/3 (67%)
		Tryp_SPc	217..448	CDD:214473	86/275 (31%)
		Tryp_SPc	218..451	CDD:238113	87/277 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910