DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ser7 and Tmprss6

DIOPT Version :9

Sequence 1:	NP_572582.1	Gene:	Ser7 / 31917	FlyBaseID:	FBgn0019929	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_082178.2	Gene:	Tmprss6 / 71753	MGIID:	1919003	Length:	811	Species:	Mus musculus

Alignment Length:	389	Identity:	109/389 - (28%)
Similarity:	166/389 - (42%)	Gaps:	79/389 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 GTCIEK----KDCDFYAVDKLMELASKQQCFSRQRPDLVC------CPRETNIIPPLAPRISNGT 91
            |.|:..    |||.....::.....:..||    :.|..|      |.|:        |...||:
Mouse   468 GLCVPACDGIKDCPNGLDERNCVCRAMFQC----QEDSTCISLPRVCDRQ--------PDCLNGS 520

  Fly    92 ------TNATSSTTTLKLLPRTTPRPPS-----------GIDQLPEHPYCG-SAFSFRLVGGHNT 138
                  ......|.|.:...|:..:.|:           |.|:  :|..|| ...|.|:|||..:
Mouse   521 DEEQCQEGVPCGTFTFQCEDRSCVKKPNPECDGQSDCRDGSDE--QHCDCGLQGLSSRIVGGTVS 583

  Fly   139 GLFEFPWTTLLEYETVSGGKDYACGASFIAQRWLLTAAHCIH---TMGRNLTAAILGEWNRDTDP 200
            ...|:||...|:..    |: :.||.:.||.||::|||||..   .....|....||:..:::.
Mouse   584 SEGEWPWQASLQIR----GR-HICGGALIADRWVITAAHCFQEDSMASPKLWTVFLGKMRQNSR- 642

  Fly   201 DCENDLNGVRECAPPHIRVTIDRILPHAQYSELNYRNDIALLRLSRPVNWLQMQNLEPVCLPPQR 265
                        .|..:...:.|:..|..:.|.::..|:|||:|..||  :....:.|||||.:.
Mouse   643 ------------WPGEVSFKVSRLFLHPYHEEDSHDYDVALLQLDHPV--VYSATVRPVCLPARS 693

  Fly   266 GRYANQLAGSAADVSGWGKTESSGS-SKIKQKAMLHIQPQDQCQEAFYKDTKITLADSQMCAGGE 329
            ..:.   .|....::|||.....|. |...||..:.:.|||.|.||:    :..::...:|||..
Mouse   694 HFFE---PGQHCWITGWGAQREGGPVSNTLQKVDVQLVPQDLCSEAY----RYQVSPRMLCAGYR 751

  Fly   330 IG-VDSCSGDSGGPLTVEANTASGNRYVYLAGVVSIGRKHCGTALFSGIYTRVSSYMDWIESTI 392
            .| .|:|.|||||||.  ....|| |: :|||:||.| ..||...|.|:||||:..::||:..:
Mouse   752 KGKKDACQGDSGGPLV--CREPSG-RW-FLAGLVSWG-LGCGRPNFFGVYTRVTRVINWIQQVL 810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser7	NP_572582.1	CLIP	29..74	CDD:197829	9/46 (20%)
		Tryp_SPc	131..388	CDD:214473	83/261 (32%)
		Tryp_SPc	133..391	CDD:238113	84/262 (32%)
Tmprss6	NP_082178.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..48
		SEA	88..185	CDD:279699
		LDLa	459..489	CDD:238060	5/20 (25%)
		LDLa	495..525	CDD:238060	9/41 (22%)
		Ldl_recept_a	529..566	CDD:278486	6/38 (16%)
		Tryp_SPc	576..806	CDD:214473	83/261 (32%)
		Tryp_SPc	577..809	CDD:238113	84/263 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910