DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ser7 and Klk12

DIOPT Version :9

Sequence 1:	NP_572582.1	Gene:	Ser7 / 31917	FlyBaseID:	FBgn0019929	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_081373.1	Gene:	Klk12 / 69511	MGIID:	1916761	Length:	247	Species:	Mus musculus

Alignment Length:	255	Identity:	81/255 - (31%)
Similarity:	114/255 - (44%)	Gaps:	44/255 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 PWTTLLEYETVSGGKDYACGASFIAQRWLLTAAHCIHTMGRNLTAAILGEWNRDTDPDCENDLNG 208
            ||...|.:     ||...||...:.::|:||||||     |:.....|||.:. |..|....|.
Mouse    34 PWQVGLFH-----GKYLRCGGVLVDRKWVLTAAHC-----RDKYVVRLGEHSL-TKLDWTEQLR- 86

  Fly   209 VRECAPPHIRVTIDRILPHAQYSELNYRNDIALLRLSRPVNWLQMQNLEPVCLPPQRGRYANQLA 273
                   |...:|..  |..|.:..|:.:|:.||||:||::..:.  :.||.||.     :....
Mouse    87 -------HTTFSITH--PSYQGAYQNHEHDLRLLRLNRPIHLTRA--VRPVALPS-----SCVTT 135

  Fly   274 GSAADVSGWGKTESSGSSKIKQKAMLHIQ--PQDQCQEAFYKDTKITLADSQMCAGGEIGVDSCS 336
            |:...|||||.|.........:...|::.  ..:.|:..|  ..::|  ::.:|||||.|.|:|.
Mouse   136 GAMCHVSGWGTTNKPWDPFPDRLQCLNLSTVSNETCRAVF--PGRVT--ENMLCAGGEAGKDACQ 196

  Fly   337 GDSGGPLTVEANTASGNRYVYLAGVVSIGR-KHCGTALFSGIYTRVSSYMDWIESTIRAN 395
            |||||||....         .|.|:||.|. ..||.....|:||:|..|.|||...||.|
Mouse   197 GDSGGPLVCGG---------VLQGLVSWGSVGPCGQKGIPGVYTKVCKYTDWIRIVIRNN 247

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser7	NP_572582.1	CLIP	29..74	CDD:197829
		Tryp_SPc	131..388	CDD:214473	76/246 (31%)
		Tryp_SPc	133..391	CDD:238113	78/249 (31%)
Klk12	NP_081373.1	Tryp_SPc	21..240	CDD:214473	76/246 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910