DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ser7 and PRSS56

DIOPT Version :9

Sequence 1:	NP_572582.1	Gene:	Ser7 / 31917	FlyBaseID:	FBgn0019929	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_001356777.1	Gene:	PRSS56 / 646960	HGNCID:	39433	Length:	604	Species:	Homo sapiens

Alignment Length:	303	Identity:	95/303 - (31%)
Similarity:	137/303 - (45%)	Gaps:	54/303 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 PRPPSGIDQLPEHPYCG---------SAFSFRLVGGHNTGLFEFPWTTLLEYETVSGGKDYACGA 164
            |||.:.:...||...||         :....|:|||.......:||...|:.    ||:. .||.
Human    73 PRPQALLQDPPEPGPCGERRPSTANVTRAHGRIVGGSAAPPGAWPWLVRLQL----GGQP-LCGG 132

  Fly   165 SFIAQRWLLTAAHC-IHTMGRNLTAAILGEWNRDTDPDCENDLNGVRECAPPHIRVTIDRILPHA 228
            ..:|..|:|||||| :......|....|.|.:|....:                .|.::|||||.
Human   133 VLVAASWVLTAAHCFVGAPNELLWTVTLAEGSRGEQAE----------------EVPVNRILPHP 181

  Fly   229 QYSELNYRNDIALLRLSRPVNWLQMQNLEPVCLP--PQRGRYANQLAGSAADVSGWGKT-ESSGS 290
            ::....:.||:||::|..||:  ...:..|||||  ||     ...||:|..::|||.. |....
Human   182 KFDPRTFHNDLALVQLWTPVS--PGGSARPVCLPQEPQ-----EPPAGTACAIAGWGALFEDGPE 239

  Fly   291 SKIKQKAMLHIQPQDQCQEAFYKDTKITLADSQMCAG---GEIGVDSCSGDSGGPLTVEANTASG 352
            ::..::|.:.:...|.|:.|.....:   ..:.:|||   |  |||||.||||||||.   :..|
Human   240 AEAVREARVPLLSTDTCRRALGPGLR---PSTMLCAGYLAG--GVDSCQGDSGGPLTC---SEPG 296

  Fly   353 NR-YVYLAGVVSIGRKHCGTALFSGIYTRVSSYMDWIESTIRA 394
            .| ...|.||.|.| ..||.....|:||||:.:.||::..:.|
Human   297 PRPREVLFGVTSWG-DGCGEPGKPGVYTRVAVFKDWLQEQMSA 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser7	NP_572582.1	CLIP	29..74	CDD:197829
		Tryp_SPc	131..388	CDD:214473	86/264 (33%)
		Tryp_SPc	133..391	CDD:238113	86/265 (32%)
PRSS56	NP_001356777.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	64..96		7/22 (32%)
		Tryp_SPc	105..335	CDD:238113	86/266 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	443..475
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	574..604
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910