DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ser7 and KLK6

DIOPT Version :9

Sequence 1:	NP_572582.1	Gene:	Ser7 / 31917	FlyBaseID:	FBgn0019929	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_001012982.1	Gene:	KLK6 / 5653	HGNCID:	6367	Length:	244	Species:	Homo sapiens

Alignment Length:	275	Identity:	85/275 - (30%)
Similarity:	125/275 - (45%)	Gaps:	65/275 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 HPYCGSAFSFRLVGGHNTGLFEFPWTTLLEYETVSGGKDYACGASFIAQRWLLTAAHCIHTMGRN 185
            |||..:.::    .||           ||            ||...|...|:||||||   ...|
Human    33 HPYQAALYT----SGH-----------LL------------CGGVLIHPLWVLTAAHC---KKPN 67

  Fly   186 LTAAILGEWNRDTDPDCENDLNGVRECAPPHIRVTIDRILPHAQYSELNYRNDIALLRLSRPVNW 250
            | ...||:.|             :|:......:.::.|.:.|..|...::..||.||||:||...
Human    68 L-QVFLGKHN-------------LRQRESSQEQSSVVRAVIHPDYDAASHDQDIMLLRLARPAKL 118

  Fly   251 LQMQNLEPVCLPPQRGRYANQLAGSAADVSGWGKTESSGSSKIKQKAMLHIQPQDQCQEAFYKDT 315
            .::  ::|  ||.:|...||.   ::..:.|||||.........|.|.:|:..:::|:.|:  ..
Human   119 SEL--IQP--LPLERDCSANT---TSCHILGWGKTADGDFPDTIQCAYIHLVSREECEHAY--PG 174

  Fly   316 KITLADSQMCAGGE-IGVDSCSGDSGGPLTVEANTASGNRYVYLAGVVSIGRKHCGTALFSGIYT 379
            :||  .:.:|||.| .|.|||.|||||||      ..|:   :|.|:||.|...||:....|:||
Human   175 QIT--QNMLCAGDEKYGKDSCQGDSGGPL------VCGD---HLRGLVSWGNIPCGSKEKPGVYT 228

  Fly   380 RVSSYMDWIESTIRA 394
            .|..|.:||:.||:|
Human   229 NVCRYTNWIQKTIQA 243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser7	NP_572582.1	CLIP	29..74	CDD:197829
		Tryp_SPc	131..388	CDD:214473	77/257 (30%)
		Tryp_SPc	133..391	CDD:238113	79/258 (31%)
KLK6	NP_001012982.1	Tryp_SPc	23..237	CDD:214473	80/267 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910