DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ser7 and MASP1

DIOPT Version :9

Sequence 1:	NP_572582.1	Gene:	Ser7 / 31917	FlyBaseID:	FBgn0019929	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	XP_011511291.1	Gene:	MASP1 / 5648	HGNCID:	6901	Length:	735	Species:	Homo sapiens

Alignment Length:	346	Identity:	99/346 - (28%)
Similarity:	159/346 - (45%)	Gaps:	73/346 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 PLAPRISNGTTNATSSTTTL---KLLPRTTPRPPSGIDQLPEHPYCGS------AFSFRLVGGHN 137
            |....::|.|...|.|...:   |:|.|:.|      ..|||   ||.      :...|::||.|
Human   407 PYYKMLNNNTGIYTCSAQGVWMNKVLGRSLP------TCLPE---CGQPSRSLPSLVKRIIGGRN 462

  Fly   138 TGLFEFPWTTLLEYETVS---GGKDYACGASFIAQRWLLTAAHCIHTMGRNLT---------AAI 190
            .....|||..|:..|..|   ..|.:..|| .::..|:|||||.:.:..|:.|         ...
Human   463 AEPGLFPWQALIVVEDTSRVPNDKWFGSGA-LLSASWILTAAHVLRSQRRDTTVIPVSKEHVTVY 526

  Fly   191 LGEWNRDTDPDCENDLNGVRECAPPHIRVTIDRILPHAQYSELNYRNDIALLRLSRPVNWLQMQN 255
            ||             |:.||:.:.. :..:..|::.|..::..||.:||||::|..||.  ...:
Human   527 LG-------------LHDVRDKSGA-VNSSAARVVLHPDFNIQNYNHDIALVQLQEPVP--LGPH 575

  Fly   256 LEPVCLP---PQRGRYANQLAGSAADVSGWGKTE---------SSGS---SKIKQKAMLHIQPQD 305
            :.|||||   |:..  |..:.|.   |:|||.:.         |||:   |.:.|...|.:.|..
Human   576 VMPVCLPRLEPEGP--APHMLGL---VAGWGISNPNVTVDEIISSGTRTLSDVLQYVKLPVVPHA 635

  Fly   306 QCQEAF-YKDTKITLADSQMCAG-GEIGVDSCSGDSGGPLTVEANTASGNRYVYLAGVVSI-GRK 367
            :|:.:: .:....::.::..||| .|.|.|:|.|||||...:..:.:  .|:| :.|:||. |.:
Human   636 ECKTSYESRSGNYSVTENMFCAGYYEGGKDTCLGDSGGAFVIFDDLS--QRWV-VQGLVSWGGPE 697

  Fly   368 HCGTALFSGIYTRVSSYMDWI 388
            .||:....|:||:||:|:||:
Human   698 ECGSKQVYGVYTKVSNYVDWV 718

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser7	NP_572582.1	CLIP	29..74	CDD:197829
		Tryp_SPc	131..388	CDD:214473	84/286 (29%)
		Tryp_SPc	133..391	CDD:238113	84/286 (29%)
MASP1	XP_011511291.1	CUB	35..144	CDD:238001
		FXa_inhibition	160..188	CDD:291342
		CUB	192..301	CDD:278839
		Sushi	308..369	CDD:278512
		CCP	374..439	CDD:153056	9/37 (24%)
		Tryp_SPc	456..718	CDD:214473	84/286 (29%)
		Tryp_SPc	457..718	CDD:238113	83/285 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910