DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ser7 and PRSS3

DIOPT Version :9

Sequence 1:	NP_572582.1	Gene:	Ser7 / 31917	FlyBaseID:	FBgn0019929	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	XP_011516267.1	Gene:	PRSS3 / 5646	HGNCID:	9486	Length:	333	Species:	Homo sapiens

Alignment Length:	305	Identity:	94/305 - (30%)
Similarity:	133/305 - (43%)	Gaps:	60/305 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 KLLPRTTPRPPSGIDQLP--EHPYCGSAFSF----RLVGGHNTGLFEFPWTTLLEYETVSGGKDY 160
            |:|.|...|   |.|.||  .....|.|..|    ::|||:.......|:...|.    ||  .:
Human    77 KILERERHR---GSDYLPIRNQNELGVAVPFDDDDKIVGGYTCEENSLPYQVSLN----SG--SH 132

  Fly   161 ACGASFIAQRWLLTAAHCIHTMGRNLTAAILGEWNRDTDPDCENDLNGVRECAPPHIRVTIDRIL 225
            .||.|.|:::|:::||||..|.    ....|||.|.......|..:|..             :|:
Human   133 FCGGSLISEQWVVSAAHCYKTR----IQVRLGEHNIKVLEGNEQFINAA-------------KII 180

  Fly   226 PHAQYSELNYRNDIALLRLSRP--VNWLQMQNLEPVCLPPQRGRYANQLAGSAADVSGWGKTESS 288
            .|.:|:.....|||.|::||.|  :| .::..:.....||        .||:...:||||.|.|.
Human   181 RHPKYNRDTLDNDIMLIKLSSPAVIN-ARVSTISLPTTPP--------AAGTECLISGWGNTLSF 236

  Fly   289 GSSKIKQKAMLH--IQPQDQCQEAFYKDTKITLADSQMCAGG-EIGVDSCSGDSGGPLTVEANTA 350
            |:....:...|.  :..|.:|:.::  ..|||  :|..|.|. |.|.|||..|||||:.....
Human   237 GADYPDELKCLDAPVLTQAECKASY--PGKIT--NSMFCVGFLEGGKDSCQRDSGGPVVCNGQ-- 295

  Fly   351 SGNRYVYLAGVVSIGRKHCGTALFSGIYTRVSSYMDWIESTIRAN 395
                   |.||||.|. .|......|:||:|.:|:|||:.||.||
Human   296 -------LQGVVSWGH-GCAWKNRPGVYTKVYNYVDWIKDTIAAN 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser7	NP_572582.1	CLIP	29..74	CDD:197829
		Tryp_SPc	131..388	CDD:214473	77/261 (30%)
		Tryp_SPc	133..391	CDD:238113	79/262 (30%)
PRSS3	XP_011516267.1	Tryp_SPc	109..325	CDD:214473	77/261 (30%)
PRSS3	XP_011516267.1	Tryp_SPc	110..328	CDD:238113	79/263 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910