DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ser7 and tmprss9

DIOPT Version :9

Sequence 1:	NP_572582.1	Gene:	Ser7 / 31917	FlyBaseID:	FBgn0019929	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	XP_021325244.1	Gene:	tmprss9 / 562051	ZFINID:	ZDB-GENE-050208-573	Length:	788	Species:	Danio rerio

Alignment Length:	377	Identity:	99/377 - (26%)
Similarity:	150/377 - (39%)	Gaps:	117/377 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 GNCNSVEF--GRGTCIEK--KDCDFYAVDKLMELASKQQCFSRQRPDLVCCPRETNIIPPLAPRI 87
            ||| ||.:  |||.||.|  .:||                      .::.||.|.:
Zfish   508 GNC-SVNYNCGRGMCISKINPECD----------------------RVIDCPNEAD--------- 540

  Fly    88 SNGTTNATSSTTTLKLLPRTTPRPPSGIDQLPEHPYCG---SAFSFRLVGGHNTGLFEFPWTTLL 149
                                           .::..||   :....|::||......|:||...|
Zfish   541 -------------------------------EKNCDCGNRPAVTQERIIGGVTARRGEWPWVGSL 574

  Fly   150 EYETVSGGKDYACGASFIAQRWLLTAAHC----IHTMGRNLTAAILGE--WNRDTDPDCENDLNG 208
            :|:.:     :.|||:.|..:||||||||    ::..|..::   ||.  |            :|
Zfish   575 QYQRI-----HRCGATLIHCKWLLTAAHCFRGDLNPAGYTVS---LGSVIW------------SG 619

  Fly   209 VRECAPPHIRVTIDRILPHAQYSELNYRNDIALLRLSRPVNWLQMQNLEPVCLPPQRGRYANQLA 273
            :.....|     :.||:||..::......|:||:.:|.|..  :...::.||||   ..:.:.:.
Zfish   620 LGALVIP-----VQRIIPHPAFNSSTMDLDVALVEISIPAP--KSYTIQTVCLP---SPWHSFIK 674

  Fly   274 GSAADVSGWGKTESSGS-SKIKQKAMLHIQPQDQCQEAFYKDTKITLADSQMCAGGEIGV-DSCS 336
            .....:.|||.....|. :.:.|||.:.:..|..||.|:..:    |.|:.||||...|. |:|.
Zfish   675 SMECYIIGWGAVREDGMITNLLQKAQVGVIDQSDCQRAYGAE----LTDNMMCAGYMEGQRDTCL 735

  Fly   337 GDSGGPLTVEANTASGNRYVYLAGVVSIGRKHCGTALFSGIYTRVSSYMDWI 388
            |||||||......   .|: :||||.|.|. .||...|.|:|.|.::..:||
Zfish   736 GDSGGPLVCRETL---GRW-FLAGVTSWGH-GCGRIGFPGVYMRATAVREWI 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser7	NP_572582.1	CLIP	29..74	CDD:197829	11/48 (23%)
		Tryp_SPc	131..388	CDD:214473	79/264 (30%)
		Tryp_SPc	133..391	CDD:238113	80/264 (30%)
tmprss9	XP_021325244.1	SEA	52..146	CDD:307516
		LDLa	185..220	CDD:238060
		Tryp_SPc	232..462	CDD:238113
		LDLa	510..544	CDD:238060	14/96 (15%)
		Tryp_SPc	557..783	CDD:238113	80/265 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910