DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ser7 and habp2

DIOPT Version :9

Sequence 1:	NP_572582.1	Gene:	Ser7 / 31917	FlyBaseID:	FBgn0019929	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_001103843.2	Gene:	habp2 / 553472	ZFINID:	ZDB-GENE-030131-4721	Length:	546	Species:	Danio rerio

Alignment Length:	479	Identity:	117/479 - (24%)
Similarity:	171/479 - (35%)	Gaps:	147/479 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 GKAIMHFGN-CNSVEFGRGTCIEKKDCDFYAVD----------KLMELASKQQCFS-------RQ 66
            ||...:..| |..|:.|.|.|:..|...||...          |.....:...|.:       |.
Zfish   108 GKKCQNEKNVCKKVKCGNGDCVRIKKDPFYECKCWPPYRGSKCKNAYACNPSPCQNGGTCVKGRT 172

  Fly    67 RPDLVC-CPRETNIIPPLAPRI----------SNGTT---NATSSTTTLKLLPRTTPRPP----S 113
            |....| ||.:      .:.|.          .||.:   |.:.:...::.||......|    .
Zfish   173 RASFTCTCPED------YSGRFCQVGSNDCYEGNGESYRGNVSETIEEIECLPWNHNLIPYKEFE 231

  Fly   114 GIDQLPEHPYC--------------------------------------------------GSAF 128
            |.:.:.||.||                                                  .:||
Zfish   232 GNESIGEHNYCRNPDGDREPWCFVKEKGKLQWNYCNVKPCSETEPEKPLTTPTKLEFSDCGKAAF 296

  Fly   129 SF---RLVGGHNTGLFEFPWTTLLEYETVSGGK--DYACGASFIAQRWLLTAAHCIHTMGRNLTA 188
            |.   |:.||..:.....||....:........  ::.||.:.|...|:|||||||
Zfish   297 SMIAPRIFGGRKSLPEAHPWQASFQVRPKGSNATFEHNCGGTLIDSCWILTAAHCI--------- 352

  Fly   189 AILGEWNRDTDPDCENDLNGV--RECAPPHIRVTIDRILPHAQYSEL--NYRNDIALLRL----S 245
                    |.:.:...:|.||  .:..|....|.:::|:.|..|:|.  ...||||||:|    .
Zfish   353 --------DENDEVRVELGGVNLEKDDPDKQFVEVEKIIVHENYTETFDALYNDIALLKLKGRNG 409

  Fly   246 RPVNWLQMQNLEPVCLP----PQRGRYANQLAGSAADVSGWGKTES-SGSSKIKQKAMLHIQPQD 305
            |..|  :.:::...|||    |:         |:...:||:|.||. .|.|.....|.:.:..|.
Zfish   410 RCAN--ESRSVRAACLPTDLFPE---------GTRCTISGYGATEKHHGVSTQLLDAKVLLISQS 463

  Fly   306 QCQEAFYKDTKITLADSQMCAGGEIG-VDSCSGDSGGPLTVEANTASGNRYVYLAGVVSIGRKHC 369
            :|........:  :.||.||||...| :|||.|||||||..:.:..   .|:|  ||||.| ..|
Zfish   464 RCMSRNVYGNR--MDDSMMCAGYMQGKIDSCQGDSGGPLVCKKDNI---HYIY--GVVSWG-DSC 520

  Fly   370 GTALFSGIYTRVSSYMDWIESTIR 393
            |.....|:|.||:.::|||...:|
Zfish   521 GKKNKPGVYARVTKFIDWINEKMR 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser7	NP_572582.1	CLIP	29..74	CDD:197829	13/62 (21%)
		Tryp_SPc	131..388	CDD:214473	81/272 (30%)
		Tryp_SPc	133..391	CDD:238113	82/273 (30%)
habp2	NP_001103843.2	EGF_CA	80..112	CDD:238011	2/3 (67%)
		EGF_CA	158..190	CDD:238011	7/37 (19%)
		KR	195..273	CDD:214527	11/77 (14%)
		Tryp_SPc	302..539	CDD:214473	81/272 (30%)
		Tryp_SPc	303..542	CDD:238113	82/274 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910