DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ser7 and C1s1

DIOPT Version :9

Sequence 1:	NP_572582.1	Gene:	Ser7 / 31917	FlyBaseID:	FBgn0019929	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_001091086.1	Gene:	C1s1 / 50908	MGIID:	1355312	Length:	694	Species:	Mus musculus

Alignment Length:	319	Identity:	88/319 - (27%)
Similarity:	130/319 - (40%)	Gaps:	81/319 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 LPRTTPRPPSGIDQLPEHPYCGSAFSFRLVGGHNTGLFEFPWTTLLEYETVSGGKDYACGASFIA 168
            |||..  |..|:   |..|:   ....|:.||....:..|||.....:...||        :.|.
Mouse   424 LPRCI--PACGV---PTEPF---QVHQRIFGGQPAKIENFPWQVFFNHPRASG--------ALIN 472

  Fly   169 QRWLLTAAHCIH----------TMGRNLT------------AAILGEWNRDTDPDCENDLNGVRE 211
            :.|:|||||.:.          ||....|            ..|...|.::.||:
Mouse   473 EYWVLTAAHVLEKISDPLMYVGTMSVRTTLLENAQRLYSKRVFIHPSWKKEDDPN---------- 527

  Fly   212 CAPPHIRVTIDRILPHAQYSELNYRNDIALLRLSRPVNWLQMQNLEPVCLPPQRGRYANQLAGSA 276
                               :..|:.|||||::|..||.  ....:.|:|||.....| |...|..
Mouse   528 -------------------TRTNFDNDIALVQLKDPVK--MGPKVSPICLPGTSSEY-NVSPGDM 570

  Fly   277 ADVSGWGKTESSGSSKIKQKAMLHIQPQDQCQEAFYKDTKI-----TLADSQMCAGGEIGVDSCS 336
            ..:||||.||........:.|.:.:...:.|::...::..:     ...|:.:|| ||.|||||.
Mouse   571 GLISGWGSTEKKVFVINLRGAKVPVTSLETCKQVKEENPTVRPEDYVFTDNMICA-GEKGVDSCH 634

  Fly   337 GDSGGPLTVEANTASGNRYVYLAGVVSIGRKHCGTALFSGIYTRVSSYMDWIESTIRAN 395
            |||||....:....:..:: |:||:||.| |.|||   .|:||:|.:|:|||..|::.|
Mouse   635 GDSGGAFAFQVPNVTVPKF-YVAGLVSWG-KRCGT---YGVYTKVKNYVDWILKTMQEN 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser7	NP_572582.1	CLIP	29..74	CDD:197829
		Tryp_SPc	131..388	CDD:214473	77/283 (27%)
		Tryp_SPc	133..391	CDD:238113	78/284 (27%)
C1s1	NP_001091086.1	CUB	24..135	CDD:238001
		FXa_inhibition	149..177	CDD:373209
		CUB	181..293	CDD:366096
		CCP	307..361	CDD:153056
		CCP	365..428	CDD:153056	3/3 (100%)
		Tryp_SPc	443..681	CDD:214473	77/283 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BFCY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900