DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ser7 and ea

DIOPT Version :9

Sequence 1:	NP_572582.1	Gene:	Ser7 / 31917	FlyBaseID:	FBgn0019929	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_524362.2	Gene:	ea / 41858	FlyBaseID:	FBgn0000533	Length:	392	Species:	Drosophila melanogaster

Alignment Length:	420	Identity:	161/420 - (38%)
Similarity:	226/420 - (53%)	Gaps:	62/420 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LIPLFLTLLG-AEAQQF-----GKAIMHFGNCNSVEFGRGTCIEKKDCDF-YAV---------DK 52
            :|.|||.:|. :.|.||     ...:.::|.|.:....|..||..:||.: |.:         |:
  Fly     6 IICLFLGILAKSSAGQFYFPNEAAQVPNYGRCITPNRERALCIHLEDCKYLYGLLTTTPLRDTDR 70

  Fly    53 LMELASKQQCFSRQRPDLVCCP---RETN--IIPPLAPRISNGTTNATSSTTTLKLLPRTTPRPP 112
            |  ..|:.||.......|:|||   ||::  ..||..|       |.||::    |||
  Fly    71 L--YLSRSQCGYTNGKVLICCPDRYRESSSETTPPPKP-------NVTSNS----LLP------- 115

  Fly   113 SGIDQLPEHPYCGSAFSFRLVGGHNTGLFEFPWTTLLEYETVSGGKDYACGASFIAQRWLLTAAH 177
                 ||..  ||:..|.|:.||..|.:.||||..|:||....|.|.:.||.|.|:.|:::||:|
  Fly   116 -----LPGQ--CGNILSNRIYGGMKTKIDEFPWMALIEYTKSQGKKGHHCGGSLISTRYVITASH 173

  Fly   178 CIHTMGR------NLTAAILGEWNRDTDPDCENDLNGVRECAPPHIRVTIDRILPHAQY--SELN 234
            |::  |:      .|:...||||:.:|:||||.|:.|:::|||||:.|.::|.:||..|  :..|
  Fly   174 CVN--GKALPTDWRLSGVRLGEWDTNTNPDCEVDVRGMKDCAPPHLDVPVERTIPHPDYIPASKN 236

  Fly   235 YRNDIALLRLSRPVNWLQMQNLEPVCLPPQRGRYANQLAGSAADVSGWGKTESSGSSKIKQKAML 299
            ..||||||||::.|.:...  :.|:|||......:....|...||:||||||...:|.:|.||.:
  Fly   237 QVNDIALLRLAQQVEYTDF--VRPICLPLDVNLRSATFDGITMDVAGWGKTEQLSASNLKLKAAV 299

  Fly   300 HIQPQDQCQEAFYKDTKITLADSQMCAGGEIGVDSCSGDSGGPLTVEANTASGNRYVYLAGVVSI 364
            .....|:||.. |....|.|.|:||||||:.|||||.||||||| :..:|...|.|.:||||||.
  Fly   300 EGFRMDECQNV-YSSQDILLEDTQMCAGGKEGVDSCRGDSGGPL-IGLDTNKVNTYYFLAGVVSF 362

  Fly   365 GRKHCGTALFSGIYTRVSSYMDWIESTIRA 394
            |...||.|.:.|:||.|..|:|||::||.:
  Fly   363 GPTPCGLAGWPGVYTLVGKYVDWIQNTIES 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser7	NP_572582.1	CLIP	29..74	CDD:197829	14/54 (26%)
		Tryp_SPc	131..388	CDD:214473	116/264 (44%)
		Tryp_SPc	133..391	CDD:238113	117/265 (44%)
ea	NP_524362.2	CLIP	37..89	CDD:288855	13/53 (25%)
		Tryp_SPc	127..386	CDD:214473	116/264 (44%)
		Tryp_SPc	128..389	CDD:238113	117/266 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	130	1.000	Domainoid score	I5140
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D402896at33208
OrthoFinder	1	1.000	-	-		FOG0003849
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.920