DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ser7 and PRSS57

DIOPT Version :9

Sequence 1:	NP_572582.1	Gene:	Ser7 / 31917	FlyBaseID:	FBgn0019929	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_999875.2	Gene:	PRSS57 / 400668	HGNCID:	31397	Length:	283	Species:	Homo sapiens

Alignment Length:	285	Identity:	77/285 - (27%)
Similarity:	117/285 - (41%)	Gaps:	51/285 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 LPEHPYCGSAFSFRLVGGHNTGLFEFPWTTLLEYETVSGGKDYACGASFIAQRWLLTAAHCIHTM 182
            ||..|..|| :..:::|||.......|:...:.:    ||:.: ||...:..||:::||||....
Human    21 LPVKPPAGS-WGAQIIGGHEVTPHSRPYMASVRF----GGQHH-CGGFLLRARWVVSAAHCFSHR 79

  Fly   183 GRNLTAAILGEWNRDTDPDCENDLNGVRECAPPHIRV-TIDRILPHAQYSELNYRNDIALLRLSR 246
            .......:||.              .|...|.|..:| .||.:..|..|..:.:.|||.||||:.
Human    80 DLRTGLVVLGA--------------HVLSTAEPTQQVFGIDALTTHPDYHPMTHANDICLLRLNG 130

  Fly   247 PVNWLQMQNLEP---VCLPPQRGRYANQLAGSAADVSGWGKTESSGSSKIK---QKAMLHIQPQD 305
            ..      .|.|   :..||.| |.....||:...|:|||..  |...::.   .:|.:.:...|
Human   131 SA------VLGPAVGLLRPPGR-RARPPTAGTRCRVAGWGFV--SDFEELPPGLMEAKVRVLDPD 186

  Fly   306 QCQEAFYKDTKITLADSQMC--AGGEIGVDSCSGDSGGPLTVEANTASGNRYVYLAGVVSIGRKH 368
            .|..::.....:|:    :|  :|.......||.||||||...      ||   ..|:||.....
Human   187 VCNSSWKGHLTLTM----LCTRSGDSHRRGFCSADSGGPLVCR------NR---AHGLVSFSGLW 238

  Fly   369 CGTALFSGIYTRVSSYMDWIESTIR 393
            ||......:||:||:::.||...:|
Human   239 CGDPKTPDVYTQVSAFVAWIWDVVR 263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser7	NP_572582.1	CLIP	29..74	CDD:197829
		Tryp_SPc	131..388	CDD:214473	69/265 (26%)
		Tryp_SPc	133..391	CDD:238113	71/266 (27%)
PRSS57	NP_999875.2	Tryp_SPc	34..258	CDD:238113	69/264 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910